Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2 API Kūlana Kiʻekiʻe
Hoʻolako ʻia ʻo Vonoprazan Fumarate a me Intermediate pili
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Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Inoa Kimia | ʻO Vonoprazan Fumarate |
| Nā huaʻōlelo like | TAK-438 |
| Helu CAS | 1260141-27-2;881681-01-2 |
| Helu CAT | RF-API99 |
| Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram |
| ʻĀpana Molekala | C21H20FN3O6S |
| Kaumaha Molecular | 461.463 |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo a ʻaneʻane-keʻokeʻo Crystalline pauda |
| ʻIke 1 H-NMR | Kūlike me ke Kūlana |
| ʻIkepili IR | ʻO ka IR Absorption spectrum o ka laʻana concordant me ka maʻamau kuhikuhi |
| ʻIke HPLC | Ka manawa paʻa o ka laʻana concordant me ka maʻamau kuhikuhi |
| Waiwai | ≤0.50% |
| Koena ma ka Ignition | ≤0.20% |
| Nā Metala Kaumaha (e like me Pb) | ≤20ppm |
| Na mea pili | |
| haumia A | ≤0.20% |
| haumia B | ≤0.15% |
| haumia C | ≤0.15% |
| ʻO nā mea haumia ʻē aʻe | ≤0.10% |
| Huina paumaele | ≤1.0% |
| Nā mea hoʻoheheʻe koena | |
| Methanol | ≤0.30% |
| Ethanol | ≤0.50% |
| Ethyl Acetate | ≤0.50% |
| Hana ʻIke / ʻIke | 98.0%~102.0% (Na HPLC) |
| Kūlana hoʻāʻo | Kūlana ʻoihana |
| Hoʻohana | API |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;Pale mai ka malamalama, ka makū.
ʻO Vonoprazan Fumurate (TAK-438) (CAS: 1260141-27-2; 881681-01-2), he mea hoʻopaʻa pāpaʻi proton (PPI), he mea hoʻopaʻapaʻa hoʻokūkū hoʻokūkū ikaika a waha (P-CAB), me ka antisecretory. hana.Hoʻopau ʻo Vonoprazan Fumarate i ka hana H+,K+-ATPase i loko o nā microsomes ʻōpū puaʻa me kahi IC50 o 19 nM ma ka pH 6.5.ʻO Vonoprazan Fumarate (Takecab), i ʻike ʻia a hoʻomohala ʻia e Takeda a me Otsuka, ua ʻae ʻia e ka PMDA o Iapana i Dekemaba 2014. Hoʻohana nui ʻia ʻo Vonoprazan Fumarate no ka mālama ʻana i ka maʻi helicobacter pylori, gastroesophageal reflux, peptic ulcer, duodenal ulcer, esophagitis, gastric ʻeha a me nā maʻi ʻē aʻe e pili ana i ka ʻōpū.Loaʻa i ka huahana kahi pale ikaika a mau loa i ka huna ʻana o ka ʻakika gastric.Ma ka lāʻau lapaʻau, ʻaʻohe hopena liʻiliʻi o Vonoprazan Fumarate i nā enzyme ʻē aʻe a liʻiliʻi ka hopena i nā hana physiological o ke kino.He palekana a ʻoi aku ka maʻalahi.
