2-(Chloromethyl)-4-Methylquinazoline CAS 109113-72-6 Linagliptin Intermediate Purity ≥99.0% (HPLC)
Chaw tsim tshuaj paus Supply Linagliptin thiab lwm yam Intermediates:
Linagliptin CAS 668270-12-0
Linagliptin Niam Txiv Nucleus Intermediate CAS 853029-57-9
8-Bromo-3-Methylxanthine CAS 93703-24-3
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine CAS 666816-98-4
2-(Chloromethyl)-4-Methylquinazoline CAS 109113-72-6
(R)-3-(Boc-Amino)piperidine CAS 309956-78-3
(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
1-Bromo-2-Butyne CAS 3355-28-0
Tshuaj npe | 2-(Chloromethyl)-4-Methylquinazoline |
Synonyms | Linagliptin Intermediate A |
CAS Nr | 109113-72-6 |
CAT Number | Qauv: RF-PI498 |
Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
Molecular Formula | C10H9ClN2 |
Molecular Luj | 192.64 ib |
Qhov ntom | 1.251 Nws |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Pale Yellow to Pale Brown Powder |
Kev Taw Qhia A | Tus qauv IR spectrum yuav tsum phim nrog tus qauv spectrum |
Kev Qhia B | Lub sijhawm khaws cia ntawm lub hauv paus ntsiab lus ncov ntawm cov qauv yuav tsum ua raws li tus qauv |
Solubility | Soluble hauv Methylene Chloride;Insoluble hauv dej |
Purity / Analysis Method | ≥99.0% (HPLC) |
Melting Point | 60.0 txog 65.0 ℃ |
Dej (KF) | ≤0.50% |
Residue ntawm Ignition | ≤0.50% |
Yam khoom muaj feem | |
Ib leeg Impurity | ≤ 0.30% |
Tag nrho cov impurities | ≤ 1.0% |
Test Standard | Enterprise Standard |
Kev siv | Intermediate rau Linagliptin (CAS: 668270-12-0) |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo.
2-(Chloromethyl)-4-Methylquinazoline (CAS: 109113-72-6) yog siv los ua ib qho nruab nrab rau kev npaj ntawm Linagliptin (CAS: 668270-12-0), thiab nws cov impurities.Linagliptin, muag raws li lub npe lag luam Tradjenta ntawm lwm tus, yog cov tshuaj siv los kho cov ntshav qab zib mellitus hom 2. Nws feem ntau tsis nyiam dua li metformin thiab sulfonylureas raws li kev kho thawj zaug.Nws yog siv ua ke nrog kev tawm dag zog thiab kev noj haus.Nws tsis pom zoo rau hom 1 mob ntshav qab zib.Nws ua haujlwm los ntawm kev tsim cov tshuaj insulin thiab txo qis glucagon los ntawm cov txiav.Linagliptin tau pom zoo siv rau kev kho mob hauv Tebchaws Meskas hauv xyoo 2011. Linagliptin yog lub zog muaj zog, xaiv dipeptidyl peptidase-4 (DPP-4) inhibitor nrog IC50 ntawm 1 nM.