5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde CAS 881674-56-2 Vonoprazan Fumarate Intermediate Purity ≥99.0%
Muab Vonoprasan Fumarate thiab Lwm Yam Nruab Nrab
5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde CAS 881674-56-2
Pyridine-3-Sulfonyl Chloride CAS 16133-25-8
Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Tshuaj npe | 5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde |
| Synonyms | Vonoprazan Fumarate (TAK-438) Nruab nrab 3 |
| CAS Nr | 881674-56-2 |
| CAT Number | Qauv: RF-PI330 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C11H8FNO |
| Molecular Luj | 189.19 Nws |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Yellow rau Brown hmoov |
| Melting Point | 122.0 ~ 131.0 ℃ |
| Kev txheeb xyuas: RT (HPLC) | Ua Raws Li Cov Qauv Siv |
| Poob Thaum Qhuav | ≤0.50% |
| Residue ntawm Ignition | ≤0.50% |
| Yam khoom muaj feem | |
| Purity | ≥99.0% |
| Ib qho Impurity | ≤0.50% |
| Tag nrho cov impurities | ≤ 1.0% |
| Test Standard | Enterprise Standard |
| Kev siv | Intermediate ntawm Vonoprasan Fumarate (TAK-438) (CAS 881681-01-2) |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde (CAS 881674-56-2) ua raws li cov tshuaj reagent nyob rau hauv cov hluavtaws npaj ntawm cov tshiab pyrrole derivatives li potassium-competitive acid blocker (P-CAB).5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde yog qhov nruab nrab ntawm Vonoprasan Fumarate (CAS 1260141-27-2).Vonoprazan fumarate (Takecab®), nrhiav pom thiab tsim los ntawm Takeda thiab Otsuka, tau pom zoo los ntawm PMDA ntawm Nyiv thaum Lub Kaum Ob Hlis 2014, thiab tau qhia rau kev kho mob plab hnyuv, duodenal ulcer thiab reflux esophagitis.Vonoprazan fumarate muaj cov txheej txheem tshiab ntawm kev ua hu ua potassium-competitive acid blockers, uas muaj kev sib tw tiv thaiv kev khi ntawm cov poov tshuaj ions rau H +, K +-ATPase (tseem hu ua lub twj tso kua mis proton) hauv cov kauj ruam kawg ntawm gastric acid secretion hauv parietal hlwb.Vonoprazan tsis inhibit Na +, K +-ATPase kev ua haujlwm txawm tias nyob rau hauv ntau dua 500 npaug siab dua li ntawm lawv cov txiaj ntsig IC50 tawm tsam plab H +, K +-ATPase kev ua haujlwm.Tsis tas li ntawd, cov tshuaj tsis cuam tshuam los ntawm lub plab zais zis, tsis zoo li PPIs.
