5-Fluorocytosine (5-FC) CAS 2022-85-7 Purity ≥99.5% (HPLC) Capecitabine Emtricitabine Intermediate Factory

5-Fluorocytosine (5-FC) CAS: 2022-85-7 Txoj Kev Ntsuas
Cov tsos mob-dawb los yog yuav luag dawb crystalline hmoov
Poob ntawm Qhuav-Siv nws ntawm 105 rau 4 teev: nws poob tsis ntau tshaj 1.50% ntawm nws qhov hnyav.
Residue ntawm Ignition-tsis ntau tshaj 0.1%.
Heavy Metals-tsis ntau tshaj 0.002%.
Fluoride-Mix 70 mL ntawm freshly npaj saturated poov tshuaj chloride tov nrog 30 mL ntawm isopropyl cawv, sau cov electrode nrog cov ntshiab supernatant, thiab cia cov electrode nyob twj ywm nyob rau hauv qhov sib tov rau tsis pub tsawg tshaj 2 teev ua ntej siv, los yog nyiam dua hmo ntuj.
Thaum noj cov ntsuas, hloov cov tshuaj mus rau 150-mL beaker, thiab raus cov electrodes.Ntxig ib qho polytef-coated stirring bar rau hauv lub beaker, tso lub beaker rau ntawm ib tug sib nqus stirrer uas muaj ib tug insulated sab saum toj, thiab cia kom do kom txog thaum sib npaug (kwv yees li 1 mus rau 2 feeb).Yaug thiab qhuav cov electrodes ntawm kev ntsuas, saib xyuas kom tsis txhob khawb cov siv lead ua hauv cov ion electrode tshwj xeeb.
Ntsuas lub peev xwm ntawm txhua qhov kev npaj, thiab npaj cov tshuaj fluoride concentration, hauv mg rau 100 mL, piv rau qhov muaj peev xwm, hauv mV, ntawm daim ntawv semilogarithmic.Ntsuas lub peev xwm ntawm Kev Ntsuas Kev Npaj, thiab txiav txim siab los ntawm tus qauv nkhaus ntawm cov tshuaj fluoride concentration, hauv mg rau 100 mL.Xam qhov feem pua ​​​​ntawm fluoride hauv feem ntawm Flucytosine coj los ntawm cov mis:
C/10
nyob rau hauv uas C yog cov fluoride concentration, nyob rau hauv mg rau 100 mL, los ntawm tus qauv nkhaus: tsis ntau tshaj 0.05% fluoride pom.
Fluorouracil-Dissolve 250 mg hauv 10 mL ntawm kev sib xyaw ntawm glacial acetic acid thiab dej (4: 1).Siv 20 µL ntawm cov tshuaj no rau ib txheej nyias txheej chromatographic phaj coated nrog 0.5-mm txheej ntawm chromatographic silica gel sib tov.Rau tib lub phaj siv 20 µL, hauv 10-µL increments, ntawm 0.025 mg ib mL tov ntawm USP Fluorouracil RS nyob rau hauv ib tug sib tov ntawm glacial acetic acid thiab dej (4: 1).Tsim cov chromatogram nyob rau hauv ib tug sib tov ntawm chloroform thiab glacial acetic acid (13:7) kom txog rau thaum cov kuab tshuaj pem hauv ntej tau tsiv tsis tsawg tshaj li 14 cm ntawm lub hauv paus chiv keeb.Tshem tawm lub phaj los ntawm kev tsim lub chamber, thiab cia cov kuab tshuaj evaporate.Nrhiav qhov chaw ntawm lub phaj los ntawm kev soj ntsuam nyob rau hauv luv luv- wavelength UV hluav taws xob: txhua qhov chaw los ntawm kev daws teeb meem nyob rau hauv kev sim tsis loj dua qhov loj thiab siv ntau dua li qhov chaw ntawm RF uas tsim los ntawm Cov Txheej Txheem Kev daws teeb meem, sib xws tsis pub ntau tshaj 0.1% ntawm tshuaj fluorouracil.
Assay-Place txog 400 mg ntawm Flucytosine, raug hnyav, hauv 250-mL beaker, ntxiv 150 mL ntawm kev sib xyaw ntawm 2 ntim ntawm glacial acetic acid thiab 1 ntim ntawm acetic anhydride, thiab yaj, sov so yog tias tsim nyog.Titrate potentiometrically nrog 0.1 N perchloric acid VS, siv lub calomel-iav electrode system.Ua ib qho kev txiav txim siab dawb paug, thiab ua ib qho kev kho uas tsim nyog.Txhua mL ntawm 0.1 N perchloric acid yog sib npaug rau 12.91 mg ntawm C4H4FN3O.Flucytosine muaj tsis pub tsawg tshaj 98.5 feem pua ​​thiab tsis ntau tshaj 101.0 feem pua ​​ntawm C4H4FN3O, xam nyob rau hauv qhuav.