6-Aminohexanoic Acid CAS 60-32-2 (ε-Aminocaproic Acid) Assay 98.5 ~ 100.5% Hoobkas

6-Aminohexanoic Acid (ε-Aminocaproic Acid) (CAS: 60-32-2) AJI97 Test Method
ε-Aminocaproic Acid, thaum xam ntawm lub hauv paus anhydrous, muaj tsis tsawg tshaj li 98.5 feem pua ​​thiab tsis ntau tshaj 100.5 feem pua ​​ntawm ε-Aminocaproic Acid (C6H13NO2).
Nqe lus piav qhia: Dawb crystals los yog crystalline hmoov, me ntsis iab saj.
Dawb soluble hauv dej thiab hauv glacial acetic acid, me ntsis soluble hauv methanol, xyaum insoluble hauv ethanol.
Solubility (H2O, g / 100g): Dawb soluble hauv dej
Kev txheeb xyuas: Sib piv cov infrared absorption spectrum ntawm cov qauv nrog cov qauv ntawm cov txheej txheem potassium bromide disc.
Specifications:
State of Solution (Transmittance): 0.5g hauv 10ml ntawm H2O, spectrophotometer, 430nm, 10mm cell thickness.
Chloride (Cl): 0.7g, A-1, ref: 0.40ml ntawm 0.01mol / L HCl
Ammonium (NH4): B-1
Sulfate (SO4): 1.2g, (1), ref: 0.50ml ntawm 0.005mol / L H2SO4
Hlau (Fe): 0.5g, ref: 1.5ml ntawm Hlau Std.(0.01 mg/ml)
Heavy Metals (Pb): 2.0g, (1), pH = 7, ref: 2.0ml ntawm Pb Std.(0.01 mg/ml)
Arsenic (As2O3): 2.0g, (1), ref: 2.0ml ntawm As2O3 Std.
Lwm cov Amino Acids: Cov qauv kuaj: 100μg, B-1-a, tswj;ε-Acp 0.6 μg
Dej: 500mg, methanol: ethyleneglycol (1:2) rau Karl Fischer Method, A, rau 15 feeb.
Residue ntawm Ignition (Sulfated): AJI Test 13
Kev Ntsuas: Cov qauv suav nrog lub hauv paus anhydrous, 130mg, (1), 3ml ntawm formic acid, 50ml ntawm glacial acetic acid, 0.1mol / L HCLO4 1ml = 13.117mg C6H13NO2
pH: 1.0g hauv 10ml H2O
Pom zoo cia txwv thiab mob: khaws cia ntim ntim ntawm qhov ntsuas kub (2 xyoos).

6-Aminohexanoic Acid (ε-Aminocaproic Acid) (CAS: 60-32-2) USP35 Test Method
Aminocaproic Acid muaj tsis tsawg dua 98.5 feem pua ​​thiab tsis ntau tshaj 101.5 feem pua ​​​​ntawm C6H13NO2, xam raws li anhydrous hauv paus.
Ntim thiab khaws cia-Txuag hauv cov thawv nruj.Khaws ntawm chav tsev kub.
USP Reference cov qauv <11>-
USP Aminocaproic Acid RS
Kev txheeb xyuas, Infrared Absorption <197K>.
Dej, Txoj Kev I <921>: tsis ntau tshaj 0.5%.
Residue ntawm ignition <281>: tsis ntau tshaj 0.1%.
Cov hlau hnyav, Txoj Kev II <231>: 0.002%.
Assay-
Kev daws A-Hloov 0.55 g ntawm sodium 1-heptanesulfonate rau 1000-mL ntim ntim, yaj hauv thiab dilute nrog dej rau ntim, thiab sib tov.
Txawb theem-Hloov 10 g ntawm monobasic poov tshuaj phosphate mus rau 1000-mL beaker, yaj nyob rau hauv 300 mL ntawm tshuaj A, ntxiv 250 mL ntawm methanol, tom qab ntawd los ntawm lwm 300 mL ntawm tshuaj A, thiab sib tov.Kho qhov sib tov nrog phosphoric acid rau pH ntawm 2.2.Hloov tag nrho cov sib tov mus rau 1000-mL volumetric hwj, dilute nrog tshuaj A rau ntim, thiab sib tov.Lim thiab degas.Ua kev hloov kho yog tias tsim nyog (saib System Suitability hauv Chromatography <621>).
Cov txheej txheem sab hauv-Npaj cov tshuaj methionine hauv dej uas muaj 1.25 mg ib mL.
Cov txheej txheem kev npaj-Dissolve ib qho hnyav hnyav ntawm USP Aminocaproic Acid RS hauv dej kom tau txais cov tshuaj Tshuag uas muaj cov ntsiab lus ntawm 12.5 mg rau ib mL.Hloov 5.0 mL ntawm Tshuag tov rau 100-mL volumetric hwj, ntxiv 2.0 mL ntawm Internal standard tov, dilute nrog dej rau ntim, thiab sib tov.
Assay npaj-Hloov ib qho hnyav hnyav ntawm 1.25 g ntawm Aminocaproic Acid mus rau 100-mL ntim ntim, yaj hauv thiab dilute nrog dej rau ntim, thiab sib tov.Hloov 5.0 mL ntawm cov tshuaj no mus rau 100-mL volumetric hwj, ntxiv 2.0mL ntawm Internal standard tov, dilute nrog dej rau ntim, thiab sib tov.
Chromatographic system (saib Chromatography <621>)-Cov kua chromatograph yog nruab nrog 210-nm ntes thiab 4.6-mm × 15-cm kem uas muaj cov ntim L1 thiab khaws cia ntawm 30 °.Tus nqi ntws yog li 0.7 mL ib feeb.Chromatograph tus qauv kev npaj, thiab sau cov lus teb ncov raws li qhia rau Cov Txheej Txheem: lub sij hawm tuav cov txheeb ze yog kwv yees li 0.76 rau aminocaproic acid thiab 1.0 rau methionine;qhov kev daws teeb meem, R, ntawm aminocaproic acid thiab methionine tsis tsawg dua 2.0;thiab tus txheeb ze tus qauv sib txawv rau kev txhaj tshuaj replicate tsis ntau tshaj 2.0%.
Cov txheej txheem-Kev txhaj tshuaj sib npaug sib npaug (kwv yees li 20 µL) ntawm Standard npaj thiab Assay npaj rau hauv chromatograph, thiab tso cai rau kev npaj Assay elute tsis pub tsawg dua ob zaug lub sij hawm tuav ntawm aminocaproic acid.Sau cov chromatograms, thiab ntsuas tag nrho cov lus teb siab kawg.Xam qhov ntau, hauv g, ntawm C6H13NO2 hauv feem ntawm Aminocaproic Acid coj los ntawm cov mis:
2C (RU / RS)
nyob rau hauv uas C yog qhov concentration, nyob rau hauv mg ib mL, ntawm USP Aminocaproic Acid RS nyob rau hauv tus txheej txheem npaj;thiab RU thiab RS yog qhov sib piv ntawm cov aminocaproic acid peak teb rau cov txheej txheem sab hauv cov lus teb siab kawg tau txais los ntawm Assay npaj thiab Standard npaj, feem.