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7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Tolvaptan Intermediate
Chaw tsim khoom, siab zoo, kev lag luam ntau lawm
Tolvaptan thiab lwm tus neeg nruab nrab:
Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3
o-Toluoyl Chloride CAS 933-88-0
Tom ntej: 4-Amino-2-Methylbenzoic Acid CAS 2486-75-1
Tom ntej: 2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5
| Tshuaj npe | 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-ib |
| Synonyms | 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one;7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ib |
| CAS Nr | 160129-45-3 |
| CAT Number | Qauv TSIS MUAJ: RF-PI395 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C10H10 NPO |
| Molecular Luj | 195.65 Nws |
| Melting Point | 103.0 txog 107.0 ℃ |
| Solubility | Soluble hauv Methanol |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Lub teeb ntsuab rau lub teeb daj hmoov |
| Cov txheej txheem qhia | NMR, HPLC |
| Purity / Analysis Method | ≥99.0% (HPLC) |
| Poob rau ziab | ≤ 1.0% |
| Residue ntawm Ignition | ≤0.50% |
| Ib qho Impurity | ≤0.50% |
| Tag nrho cov impurities | ≤ 1.0% |
| Test Standard | Enterprise Standard |
| Kev siv | Intermediate of Tolvaptan (CAS 150683-30-0), Kev kho mob ntawm Hyponatremia |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo.
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one (CAS 160129-45-3) yog ib qho nruab nrab hauv cov synthesis ntawm Tolvaptan (CAS 150683-30-0).Tolvaptan yog ib qho kev xaiv, kev sib tw ntawm qhov ncauj uas tsis yog-peptide arginine vasopressin V2 receptor antagonist nrog IC50 ntawm 1.28µM rau inhibition ntawm AVP-induced platelet aggregation.Tolvaptan yog siv los kho hyponatremia cuam tshuam nrog lub plawv tsis ua haujlwm, cirrhosis, thiab cov tsos mob ntawm cov tshuaj tiv thaiv tsis tsim nyog.Tolvaptan kuj tseem nyob rau hauv kev soj ntsuam ceev ceev rau cov kab mob polycystic raum.Kev kho mob nrog Tolvaptan ua rau lub cev hnyav thiab txo qis hauv lub cev nrog rau kev tso zis ntau ntxiv, txhim kho thiab / lossis normalizes sodium hauv cov neeg mob hyponatremic, txo cov tsos mob thiab cov tsos mob ntawm congestion thiab nce nqhis dej.
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