7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Purity > 99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Lus piav qhia luv luv:

Lub npe: 7-Chloro-6-Nitro-4-Hydroxyquinazoline

CAS: 53449-14-2 Nr

Purity:> 99.0% (HPLC)

Cov tsos mob: Lub teeb daj rau lub teeb xim av hmoov

Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Ruifu Chemical Supply Intermediates ntawm Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
Tom ntej: Dimethylamino Acetaldehyde Diethyl Acetal CAS 3616-56-6
Tom ntej: Trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-ib CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS Nr .: 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS Nr .: 314771-88-5

Chemical Properties:

Tshuaj npe	7-Chloro-6-Nitro-4-Hydroxyquinazoline
Synonyms	7-Chloro-4-Hydroxy-6-Nitroquinazoline;7-Chloro-6-Nitro-4-Quinazolinol;7-Chloro-6-Nitro-4-Quinazolinone;7-Chloro-6-Nitro-4(3H)-Quinazolinone;7-Chloro-6-Nitro-3,4-Dihydroquinazolin-4-ib;7-Chloro-6-Nitroquinazolin-4(3H)-ib
CAS Nr	53449-14-2
CAT Number	Tus Qauv Zauv: RF-PI2030
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons
Molecular Formula	C8H4ClN3O3
Molecular Luj	225.59 Nws
rhiab heev	Thaum tshav kub kub Sensitive
Solubility	Me ntsis Soluble hauv Dimethylformamide
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Lub teeb daj rau lub teeb xim av hmoov
Kev txheeb xyuas (HPLC)	Lub sijhawm khaws cia ntawm cov qauv yuav tsum sib phim nrog tus qauv
Purity / Analysis Method	> 99.0% (HPLC)
Melting Point	300.0 ~ 303.0 ℃
Cov ntsiab lus dej (KF)	<0.50%
Residue ntawm Ignition	<0.30%
impurity 1	<0.50% (7-Chloro-4-Hydroxyquinazoline CAS: 31374-18-2)
impurity 2	<0.50% (5,7-Dichloro-4 [1H]quinazolinone)
impurity 3	<1.00% (7-Chloro-8-Nitro-4[1H]quinazolinone)
Lwm Ib Leeg Impurity	<0.20%
Tag nrho cov impurities	<1.00%
Heavy Metals (raws li Pb)	<20 ppm
Infrared Spectrum	Raws li tus qauv
Proton NMR Spectrum	Proton NMR Spectrum
Test Standard	Enterprise Standard
Kev siv	Intermediate ntawm Afatinib, Afatinib Dimaleate

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo

Qhov zoo:

FAQ:

Daim ntawv thov:

7-Chloro-6-Nitro-4-Hydroxyquinazoline (CAS: 53449-14-2) yog ib qho nruab nrab ntawm Afatinib Dimaleate (CAS: 850140-73-7).Afatinib yog ib tug irreversible ErbB tsev neeg ntawm blockers uas suppress cov ntaub ntawv kis tau tus mob thiab thaiv txoj kev loj koom nyob rau hauv mob qog noj ntshav cell loj hlob thiab faib.Vim tias ErbB tsev neeg cov ntaub ntawv hloov pauv cov txheej txheem tuaj yeem tshwm sim los ntawm ntau homodimers thiab heterodimers, ib txhij inhibition ntawm ntau tus neeg hauv tsev neeg ErbB (xws li EGFR, HER2, ErbB3 thiab ErbB4) tuaj yeem cuam tshuam cov ntaub ntawv xa mus hauv qab.Afatinib yog siv los kho qee yam mob ntsws cancer (tsis yog mob ntsws me me) uas tau kis mus rau lwm qhov ntawm lub cev.Nws belongs rau ib chav kawm ntawm cov tshuaj hu ua kinase inhibitors.Nws ua haujlwm los ntawm kev qeeb lossis nres kev loj hlob ntawm cov qog nqaij hlav cancer.Nws khi rau qee yam protein (epidermal receptor-EGFR) hauv qee cov qog.