7-Ethyl-10-Hydroxycamptothecin CAS 86639-52-3 Irinotecan Hydrochloride Intermediate High Purity
Chaw tsim tshuaj paus Supply Irinotecan thiab Related Intermediates:
Tom ntej: Irinotecan Hydrochloride CAS 100286-90-6
Irinotecan Dawb Base CAS: 97682-44-5
Tom ntej: Irinotecan Hydrochloride Trihydrate CAS 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS TSIS TAU: 86639-52-3
Tom ntej: 1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Tshuaj npe | 7-Ethyl-10-Hydroxycamptothecin |
| Synonyms | NWS-38 |
| CAS Nr | 86639-52-3 |
| CAT Number | Qauv TSIS MUAJ: RF-PI242 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C22H20N2O5 |
| Molecular Luj | 392.41 ib |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Lub Teeb Yellowish Dawb Crystals Hmoov |
| Kev txheeb xyuas (IR, UV) | (1) Ultraviolet ray absorption spectrum ua raws li qhov xav tau (2) Infrared ray absorption spectrum concordant nrog cov qauv siv spectrum yuav tsum ua raws li cov kev ntsuam xyuas pom zoo |
| Melting Point | 228.0 ~ 235.0 ℃ |
| Yam khoom muaj feem | ≤ 1.5% |
| 10-Hydroxycamptothecin | ≤ 0.30% |
| 7-Cthylcamptothecin | ≤ 0.70% |
| Qhov siab tshaj plaws tsis paub impurity | ≤0.50% |
| Poob rau ziab | ≤ 1.0% |
| Hnyav Hlau | ≤10ppm |
| Residue ntawm Ignition | ≤0.10% |
| Clarity of Solution | Ntshiab |
| Assay | ≥98.0% (HPLC) |
| Test Standard | Enterprise Standard |
| Kev siv | Pharmaceutical Intermediate ntawm Irinotecan |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm 7-Ethyl-10-Hydroxycamptothecin (CAS: 86639-52-3) nrog cov khoom zoo.7-Ethyl-10-Hydroxycamptothecin (CAS: 86639-52-3) yog ib qho nquag metabolite ntawm Topoisomerase I inhibitor Irinotecan.SN-38 (NK012) inhibits DNA thiab RNA synthesis nrog IC50s ntawm 0.077 thiab 1.3 μM, feem.7-Ethyl-10-Hydroxycamptothecin (SN-38), yog cov nquag metabolite ntawm Irinotecan, ib tug semisynthetic derivative ntawm camptothecin, ib tug quinoline-raws li alkaloid pom nyob rau hauv cov tawv ntoo ntawm Suav camptotheca ntoo thiab Asian nothapodytes ntoo.Txawm hais tias 7-Ethyl-10-Hydroxycamptothecin muaj txog li 1,000 lub sij hawm muaj zog dua li Irinotecan, nws tsis tau hloov mus rau hauv cov neeg siv tshuaj siv tau vim tias nws yog insoluble.Tam sim no nws tab tom raug rau kev sim tshuaj hauv kev ua ke nrog lwm cov moieties uas thaum kawg tso cai rau nws ua tau zoo raws li cov tshuaj antineoplastic.
