Acesulfame K CAS 55589-62-3 Acesulfame Potassium Purity > 99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Acesulfame K (Acesulfame Potassium) (CAS: 55589-62-3) nrog cov khoom zoo, cov khoom noj qab zib.Ruifu tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, me me thiab ntau ntau muaj.Yuav Acesulfame K,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Acesulfame K |
| Synonyms | Acesulfame Potassium;Acesulfame Potassium ntsev;6-Methyl-1,2,3-Oxathiazin-4(3H)-ib 2,2-Dioxide Potassium ntsev;Potassium 6-Methyl-1,2,3-Oxathiazin-4(3H)-ib 2,2-Dioxide;Otizon;Potassium Acesulfame;Sunett;Sunnett;Qab zib ib;ADI |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, Commercially Manufactured |
| CAS Nr | 55589-62-3 |
| Molecular Formula | C4H4KNO4S |
| Molecular Luj | 201.24 g / mol |
| Melting Point | 229.0 ~ 232.0 ℃ (txog.) |
| rhiab heev | Moisture Sensitive |
| Dej Solubility | Soluble hauv dej, Yuav luag Transparency |
| tsw | Odorless nrog Sweet saj |
| Cia Temp. | Txias & qhuav qhov chaw (2 ~ 8 ℃, deb ntawm noo noo) |
| COA & MSDS | Muaj |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb Crystalline hmoov | Ua raws |
| Lus Assay | 99.0 ~ 101.0% (Xam rau ntawm Kev Qhuab Qhia) | 99.63% |
| Melting Point | 229.0 ~ 232.0 ℃ | Ua raws |
| Poob rau ziab | <1.00% | 0.09% |
| Sulphate Ash | <0.50% | Ua raws |
| Tus nqi pH (1 hauv 100 daws) | 5.5 ~ 7.5 hli | 6.65 ib |
| Potassium | 17.0 - 21.0% | Ua raws |
| Organic impurities | ≤ 20ppm | Ua raws |
| impurity A | ≤ 0.125% | Ua raws |
| Impurity B | ≤ 20ppm | Ua raws |
| Heavy Metals (Pb) | ≤10ppm | <5 ppm |
| Fluoride | ≤ 3ppm | Ua raws |
| Arsenic | ≤ 3ppm | Ua raws |
| Coj | ≤1ppm | Ua raws |
| Selenium | ≤10ppm | Ua raws |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj & ua raws li cov specifications | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv lub thawv kaw nruj nreem.Khaws rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
DEFINITION
Acesulfame Potassium muaj NLT 99.0% thiab NMT 101.0% ntawm C4H4NO4SK, suav ntawm lub hauv paus qhuav.
IDENTIFICATION
• A. INFRARED ABSORPTION <197K>
• B. KEV TIV THAIV-GENERAL, Potassium <191>
Sample kua: 100 mg/mL
Kev lees txais cov qauv: Ua tau raws li qhov yuav tsum tau ua
QHIA
• KEV PAB CUAM
Qauv: 150 mg
Titrimetric system (Saib Titrimetry <541>)
Hom: Direct titration
Titrant: 0.1 N perchloric acid VS
Ntim: 50 mL ntawm glacial acetic acid
Endpoint detection: Potentiometric
Kev Ntsuam Xyuas: Dissolve cov qauv hauv 50 mL ntawm glacial acetic acid.
Titrate nrog 0.1 N perchloric acid VS.Ua ib qho kev txiav txim siab dawb paug.
Xam qhov feem pua ntawm acesulfame potassium (C4H4NO4SK) hauv Cov Qauv:
Cov txiaj ntsig = [(V − B) × N × F × 100]/W
V = titrant ntim noj los ntawm Sample (mL)
B = titrant ntim tau noj los ntawm Blank (mL)
N = titrant tseeb normality (mEq/mL)
F = equivalency factor, 201.2 mg/mEq
W = qhov hnyav ntawm Sample (mg)
Kev lees txais: 99.0% - 101.0% ntawm lub hauv paus qhuav
IMPURITIES
• LIMIT OF fluoride
[CEEB TOOM-Siv plasticware thoob plaws qhov kev sim no.]
Kev daws A: Dissolve 210 g ntawm citric acid monohydrate hauv 400 mL dej.Kho nrog concentrated ammonia mus rau pH ntawm 7.0, thiab dilute nrog dej mus rau 1000 mL.
Kev daws B: 132 mg / mL ntawm dibasic ammonium phosphate
Kev daws C: Rau kev ncua ntawm 292 g ntawm edetic acid hauv 500 mL dej, ntxiv 200 mL ntawm ammonium hydroxide, kho nrog ammonium hydroxide rau pH ntawm 6 thiab 7, thiab dilute nrog dej kom 1000 mL.
Buffer tov: Sib tov sib npaug ntawm cov tshuaj A, tshuaj B thiab tshuaj C, thiab kho nrog ammonium hydroxide mus rau pH ntawm 7.5.
Cov txheej txheem kev daws teeb meem: hnyav 0.442 g ntawm sodium fluoride, yav tas los qhuav ntawm 300 ° rau 12 h, rau hauv 1-L ntim ntim, thiab dilute nrog dej rau ntim.Khaws cov tshuaj rau hauv lub thawv yas kaw.Tam sim ntawd ua ntej siv, pipet 5 mL ntawm cov tshuaj no rau hauv 100-mL volumetric hwj, thiab dilute nrog dej rau ntim.Txhua mL ntawm cov tshuaj no muaj 10µg ntawm fluoride ion.
Standard tov A: Sib tov 0.5 mL ntawm Standard Tshuag tov thiab 15.0 mL ntawm Buffer tov, thiab dilute nrog dej mus rau 50mL.
Standard tov B: Sib tov 1.0 mL ntawm Standard Tshuag tov thiab 15.0 mL ntawm Buffer tov, thiab dilute nrog dej mus rau 50mL.
Standard tov C: Sib tov 1.5 mL ntawm Standard Tshuag tov thiab 15.0 mL ntawm Buffer tov, thiab dilute nrog dej mus rau 50mL.
Standard tov D: Sib tov 3.0 mL ntawm Standard Tshuag tov thiab 15.0 mL ntawm Buffer tov, thiab dilute nrog dej mus rau 50mL.
Piv txwv li: Rau 50-mL volumetric hwj ntxiv 3 g ntawm Acesulfame Potassium.Dissolve hauv dej, ntxiv 15.0 mL ntawm Buffer tov, thiab dilute nrog dej rau ntim.
Kev tsom xam
Qauv: Cov qauv tshuaj A, Standard tov B, Standard tov C, Standard tov D, thiab cov qauv tov
Concomitantly ntsuas lub peev xwm (saib Titrimetry <541>) nyob rau hauv mV, ntawm cov qauv kev daws teeb meem thiab cov qauv tov, nrog ib tug haum pH meter nruab nrog ib tug fluoride-tshwj xeeb electrode thiab ib tug silver-silver chloride siv electrode.Thaum noj cov ntsuas, hloov cov tshuaj mus rau 25-mL beaker, thiab raus cov electrodes.Ntxig ib qho polytef-coated stirring bar rau hauv lub beaker, tso lub beaker rau ntawm ib tug sib nqus stirrer uas muaj ib tug insulated sab saum toj thiab cia kom do kom txog thaum sib npaug (1-2 min).Yaug, thiab qhuav cov electrodes ntawm kev ntsuas, saib xyuas kom tsis txhob khawb cov siv lead ua hauv cov tshuaj fluoride tshwj xeeb ion electrode.Ntsuas lub peev xwm ntawm txhua qhov kev daws teeb meem, thiab npaj cov tshuaj fluoride concentration, hauv µg / mL, piv rau qhov muaj peev xwm, hauv mV, ntawm daim ntawv semilogarithmic.Ntsuas qhov muaj peev xwm ntawm cov qauv tshuaj, thiab txiav txim siab cov tshuaj fluoride los ntawm tus qauv nkhaus, hauv µg / mL.
Xam cov ntsiab lus, hauv ppm, ntawm fluoride hauv feem ntawm Acesulfame Potassium noj:
Cov txiaj ntsig = (V × C / W)
V = volume of the Sample solution (mL)
C = concentration ntawm fluoride nyob rau hauv cov qauv tov, los ntawm tus qauv nkhaus (mg/mL)
W = qhov hnyav ntawm Acesulfame Potassium coj los npaj Sample tov (g)
Kev lees txais: NMT 3 ppm
• Hnyav hlau, Txoj Kev I <231>: NMT 10 ppm
• CHROMATOGRAPHIC PURITY
Kev daws A: 3.3 mg / mL ntawm tetrabutylammonium hydrogen sulfate
Mobile theem: Acetonitrile thiab tshuaj A (2: 3)
Kev daws teeb meem tsim nyog: 2 µg / mL txhua ntawm USP Acesulfame Potassium RS thiab ethylparaben
Kev daws teeb meem: 0.2 µg / mL ntawm USP Acesulfame Potassium RS
Sample kua: 10 mg/mL
Chromatographic system
(Saib Chromatography <621>, System Suitability.)
Qauv: LC
Detector: UV 227 nm
Kem: 4.6-mm × 25-cm;5-µm ntim L1
Tus nqi ntws: 1 mL / min
Kev txhaj tshuaj loj: 20 µL
Qhov system haum
Qauv: Kev daws teeb meem tsim nyog
Suitability xav tau
Kev daws teeb meem: NLT 2 ntawm acesulfame potassium thiab ethylparaben
Kev tsom xam
Qauv: Cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem
Sau cov chromatograms rau lub sijhawm khiav NLT 3 zaug ntawm lub sijhawm khaws cia ntawm acesulfame potassium ncov, thiab ntsuas thaj tsam cov lus teb ntawm lub ncov.
Kev lees txais cov txheej txheem: Cov lus teb ntawm ib qho ncov ntawm lub sijhawm khaws cia uas tsis yog ntawm acesulfame potassium los ntawm cov qauv tshuaj tsis tshaj cov lus teb ntawm acesulfame potassium ncov los ntawm Standard tov (0.002%).
TSEEM CEEB
• ACIDITY lossis ALKAINITY
Piv txwv li: 4.0 g nyob rau hauv 20 mL ntawm carbon dioxide-dawb dej
Kev tshuaj xyuas: Ntxiv 0.1 mL ntawm bromothymol xiav TS.Yog tias cov tshuaj yog daj, titrate nrog 0.01 N sodium hydroxide los ua xim xiav.Yog hais tias cov tshuaj yog xiav, titrate nrog 0.01 N hydrochloride acid los ua xim daj.
Kev lees txais: NMT 0.2 mL ntawm 0.01 N sodium hydroxide lossis NMT 0.2 mL ntawm 0.01 N hydrochloric acid yog xav tau.
• LOSS RAU DRYING <731>: Qhuav ib qho qauv ntawm 105 ° rau 3 h: nws poob NMT 1.0% ntawm nws qhov hnyav.
TSEEM CEEB
• Ntim thiab khaws cia: Khaws rau hauv lub thawv kaw kom zoo, thiab tiv thaiv lub teeb.Khaws ntawm chav tsev kub.
USP REFERENCE STANDARDS <11>
USP Acesulfame Potassium RS
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Risk Codes 36/37/38 - Irritating rau qhov muag, ua pa thiab tawv nqaij.
Kev nyab xeeb piav qhia
S26 - Nyob rau hauv rooj plaub ntawm qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
S36/37/39 - Hnav cov khaub ncaws tiv thaiv, hnab looj tes thiab tiv thaiv qhov muag / ntsej muag.
WGK Germany 1
TIAB SA RP4489165
HS Code 2934990002
Toxicity LD50 hauv nas (mg / kg): 7431 qhov ncauj, 2243 ip (Mayer, Kemper)
Xyoo 1976, Acesulfame-K tau tsim thawj zaug
Xyoo 1983, EU pom zoo siv rau hauv cov zaub mov thiab dej haus
1988, FDA pom zoo nws siv hauv cov khoom qab zib, cov pos hniav thiab kas fes
Xyoo 1992, Tuam Tshoj tau pom zoo siv rau hauv cov khoom noj thiab dej haus
Xyoo 1994, FDA pom zoo nws siv hauv syrup, bakery thiab khoom noj siv mis
1995, FDA pom zoo nws siv hauv cawv
1998, FDA pom zoo nws siv hauv cov dej qab zib
Xyoo 2000, Nyiv tau pom zoo siv nws
Acesulfame K (Acesulfame Potassium) (CAS: 55589-62-3) yog ib qho khoom qab zib.
Raws li cov khoom qab zib uas tsis yog khoom noj khoom haus, nws yog qhov tseem ceeb tsis muaj kev hloov pauv hauv cov ntsiab lus ntawm cov khoom noj thiab dej haus siv nyob rau hauv cov pH dav dav.
Cov ntawv thov feem ntau ntawm Acesulfame-K yog cov lus siv, zom cov pos hniav, dej haus, khoom noj, khoom noj khoom haus, khoom noj khoom haus, khoom noj hauv qhov ncauj, thiab tshuaj.
Qab zib.Tom qab noj cov tib neeg lub cev tsis absorbed, tsis tsim tshav kub, haum rau siv nyob rau hauv cov neeg mob ntshav qab zib thiab rog.Nws tuaj yeem siv ib leeg lossis ua ke nrog lwm cov khoom qab zib.Acesulfame K feem ntau sib xyaw nrog lwm cov khoom qab zib (feem ntau Sucralose lossis Aspartame).Cov kev sib xyaw no muaj npe nrov kom muab cov sucrose ntau dua li saj uas yog txhua tus qab zib qhov ncauj qhov ntswg rau lwm tus tom qab saj, thiab / lossis nthuav tawm cov txiaj ntsig sib xyaw uas qhov sib xyaw yog qab zib dua li nws cov khoom.
Tsis zoo li Aspartame, Acesulfame K yog ruaj khov nyob rau hauv tshav kub, txawm nyob rau hauv me ntsis acidic los yog yooj yim tej yam kev mob, cia nws yuav siv tau raws li ib tug khoom noj additive nyob rau hauv ci, los yog nyob rau hauv cov khoom uas yuav tsum tau ib tug ntev lub neej txee.Hauv cov dej qab zib carbonated, nws yuav luag txhua zaus siv nrog lwm cov khoom qab zib, xws li Aspartame lossis Sucralose.Nws kuj yog siv los ua cov khoom qab zib hauv cov protein shakes thiab cov khoom siv tshuaj, tshwj xeeb tshaj yog chewable thiab kua tshuaj, qhov twg nws tuaj yeem ua rau cov khoom xyaw nquag palatable.
Acesulfame potassium yog siv los ua cov khoom qab zib hauv cov tshuaj pleev ib ce, khoom noj, dej haus, cov khoom qab zib, cov tshuaj vitamin thiab cov tshuaj npaj, suav nrog cov hmoov sib tov, ntsiav tshuaj, thiab cov khoom ua kua.Nws yog dav siv los ua cov piam thaj hloov hauv cov tshuaj sib xyaw ua ke, thiab ua cov tshuaj txhuam hniav sweetener.Qhov kwv yees lub zog qab zib yog 180-200 npaug ntawm sucrose, zoo ib yam li aspartame, kwv yees li ib feem peb ntawm qab zib li sucralose, ib nrab ntawm qab zib li sodium saccharin, thiab li 4-5 npaug sweeter dua sodium cyclamate. thiab tuaj yeem siv los npog qee qhov tsis zoo saj yam ntxwv.
Acesulfame Potassium yog siv dav hauv dej haus, tshuaj pleev ib ce, khoom noj, thiab tshuaj formulations, thiab feem ntau suav hais tias yog cov khoom tsis muaj tshuaj lom thiab tsis muaj tshuaj lom.Kev tshawb fawb Pharmacokinetic tau pom tias acesulfame potassium tsis metabolized thiab tawm sai sai tsis hloov pauv hauv cov zis.Kev tshawb fawb txog kev noj zaub mov ntev hauv nas thiab dev tsis pom muaj pov thawj qhia tias acesulfame potassium yog mutagenic lossis carcinogenic.
Lub koom haum WHO tau teeb tsa kev noj haus txhua hnub rau acesulfame poov tshuaj txog li 15 mg / kg lub cev qhov hnyav.Lub Scientific Committee for Foods ntawm European Union tau teeb tsa ib hnub kom muaj nuj nqis txog li 9 mg / kg ntawm lub cev qhov hnyav.
LD50 (rat, IP): 2.2 g/kg
LD50 (rat, qhov ncauj): 6.9–8.0 g / kg
Acesulfame Potassium muaj kev ruaj ntseg zoo.Nyob rau hauv daim ntawv loj nws qhia tsis tau hais tias decomposition ntawm ambient kub ntau xyoo.Tsis muaj kev txo qis hauv qab zib tau pom nyob rau lub sijhawm kwv yees li 2 xyoos.Kev ruaj ntseg ntawm qhov kub siab yog qhov zoo, txawm hais tias qee qhov decomposition tau sau tseg tom qab khaws cia ntawm 408 ℃ rau ob peb lub hlis.Sterilization thiab pasteurization tsis cuam tshuam qhov saj ntawm acesulfame potassium.
Cov khoom siv loj yuav tsum muab khaws cia rau hauv lub thawv kaw kom zoo hauv qhov chaw txias, qhuav thiab tiv thaiv los ntawm lub teeb.
Muaj nyob rau hauv FDA Inactive Ingredients Database rau qhov ncauj thiab sublingual npaj.Muaj nyob rau hauv Canadian daim ntawv teev cov khoom uas tsis yog tshuaj.Txais siv nyob rau hauv Teb chaws Europe raws li ib tug khoom noj additive.Nws tseem raug lees txais los siv rau hauv qee yam khoom noj hauv Asmeskas thiab ntau lub tebchaws hauv Central thiab South America, Middle East, Africa, Asia, thiab Australia.
