Adenosine CAS 58-61-7 Assay 99.0% -101.0% USP Standard Hoobkas High Purity

Lus piav qhia luv luv:

Lub npe: Adenosine

CAS: 58-61-7 Nr

Cov tsos mob: Dawb crystalline hmoov, tsw ntxhiab

Kev Ntsuas: 99.0% ~ 101.0% (ntawm lub hauv paus qhuav)

USP35 Txuj, Siab Zoo, Kev Lag Luam Ntau Lawm

Hu rau: Dr. Alvin Huang

Txawb/Wechat/WhatsApp: +86-15026746401

Inquiry: alvin@ruifuchem.com

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Product Detail

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Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm Adenosine (CAS: 58-61-7) nrog cov khoom zoo, ua tau raws li USP tus qauv, AJI97 tus qauv.Ruifu Chemical muab cov Nucleosides, Nucleotides, Nucleic Acids.Peb tuaj yeem muab kev xa khoom thoob ntiaj teb, me me thiab ntau qhov ntau.Yog tias koj txaus siab rau Adenosine (CAS: 58-61-7), Please contact: alvin@ruifuchem.com

Chemical Properties:

Lub npe	Adenosine
Synonyms	D-Adenosine;Adenosine, Dawb Base;Adenocard;Adenine Riboside;9-beta-D-Ribofuranosyladenine;9-β-D-Ribofuranosyladenine;6-Amino-9β-D-Ribofuranosyl-9H-Purine;6-Amino-9 (β-D-Ribofuranosyl)-9H-Purine;Adenine-9-beta-D-Ribofuranoside
CAS Nr	58-61-7
Tshuag xwm txheej	Hauv Tshuag, Muaj Peev Xwm Ntau Lawm 500 Tons ib xyoos
Molecular Formula	C10H13N5O4
Molecular Luj	267.25 Nws
Melting Point	233.0 ~ 238.0 ℃
rhiab heev	Huab cua Sensitive
Solubility	Me ntsis soluble hauv dej, Soluble hauv dej kub, xyaum Insoluble hauv Ethanol (96 feem pua) thiab hauv Methylene Chloride
Solubility hauv dej kub	Yuav luag Transparency
Kev faib tawm	Nucleosides, Nucleotides, Nucleic Acids
Hom	Ruifu Tshuaj

58-61-7 Cov Ntaub Ntawv Kev Nyab Xeeb:

Risk Statements	36/37/38 ib	F	10-23
Cov lus hais txog kev nyab xeeb	24/25-36/37/39-26 ib	TSCA	Yog lawm
WGK Germany	2	HS Code	2934993090 ib
RTECS	UA 7175000	Toxicity	LD50 qhov ncauj hauv nas:> 20gm / kg

Specifications:

Cov khoom	Kev soj ntsuam Standards	Cov txiaj ntsig
Qhov tshwm sim	Dawb Crystalline Hmoov, Tsis muaj ntxhiab tsw	Ua raws
Kev txheeb xyuas	IR Conforms rau Kev Siv	Ua raws
Kev sib hloov tshwj xeeb [a]20/D	-68.0° ~ 72.0° (C = 2 in 5% NaOH)	-71.7° Nws
Melting Point	233.0 ~ 238.0 ℃	235.0 ~ 236.0 ℃
Acidity los yog Alkalinity	Ua tau raws li qhov yuav tsum tau ua	Ua raws
Poob rau ziab	≤0.50%	0.04%
Hnyav Hlau	≤10ppm	<10ppm
Residue ntawm Ignition	≤0.10%	0.08%
Txwv ntawm Ammonia	≤ 0.0004%	<0.0004%
Txwv ntawm chloride	≤ 0.007%	<0.007%
Kev txwv ntawm Sulfate	≤ 0.02%	<0.02%
Guanosine	≤0.10%	Tsis muaj
Insine	≤0.10%	0.01%
Uridine	≤0.10%	Tsis muaj
Adenine	≤0.10%	Tsis muaj
Tag nrho cov impurities	≤0.50%	0.03%
Assay	99.0 ~ 101.0% (ntawm lub hauv paus qhuav)	100.3%
Test Standard	USP35 Txuj	Ua raws
Cov khoom siv hauv qab	Adenosine Triphosphate (ATP), Adenine, Adenylate, Adenosine Arabinose

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo.Incompatible nrog muaj zog oxidizing neeg sawv cev.

58-61-7 USP35 Test Method:

DEFINITION
Adenosine muaj NLT 99.0% thiab NMT 101.0% ntawm C10H13N5O4, suav ntawm lub hauv paus qhuav.
IDENTIFICATION
• A. INFRARED ABSORPTION <197K>: NMT 0.1%
QHIA
• ADENOSINE
Qauv: 200 mg ntawm Adenosine yav tas los qhuav ntawm 105 ° rau 2h
Titrimetric system
(Saib Titrimetry <541>)
Hom: Direct titration
Titrant: 0.1 N rau chloric acid VS
Endpoint detection: Potentiometric
Kev tshuaj xyuas: Dissolve hauv 50 mL ntawm glacial acetic acid thiab titrate nrog 0.1 N ib chloric acid VS.Xam cov feem pua ntawm Adenosine (C10H13N5O4) nyob rau hauv feem:
Cov txiaj ntsig = [(V − B) × N × F × 100]/W
V = Sample titrant ntim (mL)
B = Qhov ntim titrant (mL)
N = titrant normality (mEq/mL)
F = equivalency factor: 267.25 mg/mEq
W = qhov hnyav ntawm tus qauv (mg)
Kev lees txais: 99.0% -101.0% ntawm lub hauv paus qhuav
• IMPURITIES
• RESIDUEON IGNITION <281>: NMT 0.1%
• HEAVY METALS, Method II <231>: NMT 10 ppm
• LIMIT NTAWM AMMONIA
Piv txwv li: Suspend 0.5 g hauv 10 mL dej.Do rau 30 s, thiab dhau los ntawm lub lim dej ntxhib.Dilute lub filtrate nrog dej mus rau 15 mL, thiab siv cov filtrate.
Kev daws teeb meem: 0.4 µg / mL ntawm ammonium chloride hauv dej
Kev tsom xam: Rau cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem ntxiv 0.3 mL ntawm alkaline mer curic-potassium iodide TS, cap lub raj, thiab cia sawv ntsug rau 5 feeb.
Kev lees txais cov qauv: Cov qauv kev daws teeb meem tsis pom cov xim daj ntau dua li cov txheej txheem kev daws teeb meem (NMT 4 ppm ntawm ammonia).
• LIMIT CHLORIDE
Piv txwv li: Suspend 0.2 g hauv 10 mL dej.Do rau 30 s, hla dhau lub lim dej ntxhib, thiab siv cov lim dej.
Kev daws teeb meem: 2.3 µg / mL ntawm sodium chloride hauv dej
Kev tsom xam: Rau cov qauv tov thiab 10 mL ntawm Standard tov ntxiv 1 mL ntawm nitric acid thiab 1 mL ntawm silver nitrate TS, thiab dilute txhua tov nrog dej mus rau 40 mL.Cia cov kev daws teeb meem sawv ntsug li 5 feeb, tiv thaiv los ntawm lub teeb.
Kev lees txais cov txheej txheem: Thaum saib tawm tsam keeb kwm yav dhau los tsaus nti, cov qauv kev daws teeb meem tsis yog turbid ntau dua li cov qauv tshuaj (NMT 0.007% chloride).
• LIMIT NTAWM SULFATE
Piv txwv li: Suspend 0.75 g hauv 15 mL dej.Do rau 30 s, hla dhau lub lim dej ntxhib, thiab siv cov lim dej.
Kev daws teeb meem: Ntxiv 0.15 mL ntawm 0.020 N sulfuric acid rau 15 mL dej.
Kev tsom xam: Rau cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem ntxiv 2 mL ntawm barium chloride TS thiab 1 mL ntawm 3 N hydrochloric acid, dilute txhua cov tshuaj nrog dej rau 30 mL, thiab sib tov.Cia cov kev daws teeb meem sawv ntsug li 5 feeb.
Kev lees txais cov qauv: Cov qauv kev daws teeb meem tsis yog turbid ntau dua li cov qauv kev daws teeb meem (NMT 0.02% sulfate).
• ORGANIC IMPURITIES
Kev daws A: 6.8 g / L ntawm poov tshuaj hydrogen sulfate thiab 3.4g / L ntawm tetrabutylammonium hydrogen sulfate hauv dej.Kho nrog 2 N potassium hydroxide rau pH ntawm 6.5.
Kev daws B: 0.1 g / L ntawm sodium azide tov
Mobile Theem: Solution A thiab Solution B (60:40)
Qhov kev daws teeb meem tsim nyog: 0.2 mg / mL txhua ntawm Adenosine thiab inosine hauv Mobile theem
Cov qauv kev daws teeb meem: 1.0 mg / mL ntawm Adenosine nyob rau theem Mobile
Chromatographic system
(Saib Chromatography <621>, System Suitability.)
Qauv: LC
Detector: UV 254 nm
Kem: 4.6-mm × 25-cm;5-µm ntim L1
Tus nqi ntws: 1.5 mL / min
Kev txhaj tshuaj loj: 20 µL
Qhov system haum
Qauv: Kev daws teeb meem tsim nyog
Suitability xav tau
Kev daws teeb meem: NLT 9.0 ntawm adenosine thiab inosine
Tus Qauv Zauv: NMT 2.5
Tus qauv sib txawv: NMT 2.0%
[CEEB TOOM-Chromatograph cov qauv kev daws teeb meem, thiab kho lub sijhawm khiav mus rau tsawg kawg ob zaug lub sijhawm tuav ntawm lub ncov loj.]
Kev tsom xam
Qauv: qauv tov
Xam cov feem pua ntawm txhua qhov impurity hauv feem ntawm Adenosine noj:
Cov txiaj ntsig = (rU/rT) × 100
rU = ncov teb ntawm txhua impurity los ntawm cov qauv tov
rT = sum ntawm tag nrho cov lus teb rau tag nrho cov peaks los ntawm cov qauv tov
Kev lees txais
Ib tug neeg impurities: NMT 0.1% txhua ntawm guanosine, inosine, thiab uridine, thiab NMT 0.2% ntawm adenine
Tag nrho impurities: NMT 0.5%
TSEEM CEEB
• MELTING RANGE LOS SIS KUB <741>: 233°-238°
• OPTICAL ROTATION, Tshwj xeeb kev sib hloov <781S>: -68 ° txog -72 °
Kev ntsuas tshuaj: 20 mg / mL hauv sodium hydroxide tov (1 hauv 20), txiav txim siab ntawm cov qauv yav dhau los qhuav ntawm 105 ° rau 2h
ACIDITY LOSSIS ALKALINITY: Ncua 1 g hauv 20 mL dej tsis muaj carbon dioxide.Do rau 30 s, thiab dhau los ntawm lub lim dej ntxhib.Rau txhua ntawm ob 10-mL feem ntawm cov lim ntxiv 0.1mL ntawm bromocresol ntshav TS.
Kev lees txais: NMT 0.3 mL ntawm 0.01 N sodium hydroxide yuav tsum tsim kom muaj xim xiav-violet hauv ib feem.NMT 0.1 mL ntawm 0.01 N hydrochloric acid yuav tsum tau ua kom muaj xim daj hauv lwm qhov.
•LOSSON DRYING <731>: Qhuav ib qho qauv ntawm 105 ℃ rau 2 h: nws poob NMT 0.5% ntawm nws qhov hnyav.
TSEEM CEEB
• Ntim thiab Cia: Khaws rau hauv cov thawv nruj, lub teeb-resistant, thiab khaws cia ntawm chav tsev kub.
• USP REFERENCE STANDARDS <11>
USP Adenosine RS

Qhov zoo:

FAQ:

Daim ntawv thov:

Kev Ua Haujlwm thiab Kev Siv Adenosine (CAS: 58-61-7)
1. Adenosine yog ib qho protein kinase activators.Txhim kho myocardial hypoxia, coronary artery expansion, nce myocardial contractility, nce plawv tso zis thiab lwm yam teebmeem rau angina pectoris, mob myocardial infarction adjuvant therapy, tab sis nws lub luag haujlwm hauv kev tswj lub sijhawm luv.Siv los txo angina thiab mob thiab mob myocardial infarction thiab lwm yam kab mob.Adenosine plays lub luag haujlwm physiological ntawm cov hlab plawv thiab lub cev ntau lub cev thiab cov koom haum.
2. Adenosine yog siv nyob rau hauv cov synthesis adenosine triphosphate, adenosine (ATP), adenine, adenosine, cov vidarabine tseem ceeb intermediates.Adenosine tsuas yog siv hauv kev lag luam kws tshuaj rau kev tsim cov adenosine;adenosine triphosphate;coenzyme thiab nws cov series ntawm cov khoom xws li cyclic adenosine phosphate thiab lwm yam tshuaj raws li lub ntsiab raw khoom.
3. Adenosine plays lub luag haujlwm tseem ceeb hauv biochemistry, suav nrog adenosine triphosphate (ATP) lossis adeno-bisphosphate (ADP) daim ntawv hloov hluav taws xob, lossis rau cyclic adenosine monophosphate (cAMP) rau kev xa cov teeb liab thiab lwm yam.Tsis tas li ntawd, adenosine yog ib qho inhibitory neurotransmitter (inhibitory neurotransmitter), tuaj yeem txhawb kev pw tsaug zog.
4. Adenosine yog ib qho amino acid.Cov kev tshawb fawb qhia tias muaj peev xwm tiv thaiv wrinkle thiab skinsmoothing.Txawm hais tias me ntsis sau txog nws cov txiaj ntsig ncaj qha ntawm daim tawv nqaij, adenosine plays lub luag haujlwm tseem ceeb hauv cov txheej txheem biochemical.Raws li adenosine triphosphate (ATP) thiab adenosine diphosphate (ADP), nws koom nrog hauv kev hloov hluav taws xob, thiab raws li cyclic adenosine monophosphate (cAMP) hauv cov teeb liab hloov.
5. Adenosine yog ib qho tshuaj antiarrhythmic uas hloov paroxysmal supraventricular tachycardia mus rau sinus atherosclerosis.Nws yog siv rau supraventricular arrhythmias ntsig txog atrioventricular.