Afatinib CAS 439081-18-2 Purity > 99.5% (HPLC) Hoobkas

Lus piav qhia luv luv:

Lub npe tshuaj: Afatinib

Synonyms: BIBW2992

CAS: 439081-18-2 Nr

Purity:> 99.5% (HPLC)

Cov tsos mob: Off-White Powder

E-Mail: alvin@ruifuchem.com

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Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Ruifu Chemical Supply Intermediates ntawm Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
Tom ntej: Dimethylamino Acetaldehyde Diethyl Acetal CAS 3616-56-6
Tom ntej: Trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-ib CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS Nr .: 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS Nr .: 314771-88-5

Chemical Properties:

Tshuaj npe	Afatinib
Synonyms	PAB 2992;BIBW-2992;BIBW2992 Dawb Base;Tomtovok;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(Dimethylamino)tab sis-2-Enamide
CAS Nr	439081-18-2
CAT Number	Qauv TSIS MUAJ: RF-PI2033
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons
Molecular Formula	C24H25ClFN5O3
Molecular Luj	485.94 ib
Solubility	Soluble hauv DMSO
Qhov ntom	1.380 Nws
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Off-White hmoov
Kev txheeb xyuas	HPLC, NMR
Purity / Analysis Method	> 99.5% (HPLC)
Melting Point	100.0 ~ 102.0 ℃
Poob rau ziab	<0.50%
Residue ntawm Ignition	<0.20%
Tag nrho cov impurities	<0.50%
Hnyav Hlau	≤ 20ppm
NMR Spectrum	Raws li tus qauv
Test Standard	Enterprise Standard
Txee lub neej	24 Lub Hlis yog khaws cia kom raug
Kev siv	API;Afatinib;Afatinib Dimaleate;NSCLC

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo

Qhov zoo:

FAQ:

Daim ntawv thov:

Afatinib, tseem hu ua BIW-2992, (CAS: 439081-18-2) yog lub thib ob-tiam muaj zog thiab irreversible dual inhibitor ntawm epidermal loj hlob yam receptor (EGFR) thiab human epidermal growth factor receptor 2 (HER2) tyrosine kinase, tsim los ntawm Boehringer Ingelheim, lub teb chaws Yelemees.Nws muaj peev xwm ntawm irreversibly inhibiting kev ua ntawm tyrosine kinase los ntawm kev mus rau Michael cov tshuaj tiv thaiv nrog thiol pawg ntawm cysteine ntawm txoj hauj lwm 797 ntawm EGFR.Thaum Lub Xya Hli 12, 2013, nws tau dhau los ua cov tshuaj tshiab rau kev tiv thaiv kab mob ntsws me me uas tau pom zoo los ntawm US FDA raws li lub npe lag luam ntawm Gilotrif.Cov tshuaj no yog ib ntsiav tshuaj.Nws yog siv rau kev kho mob ntawm cov neeg mob uas kuaj pom muaj metastatic tsis-me me ntsws qog nqaij hlav cancer (NSCLC) nrog kev poob ntawm 19th exon los yog L858R kev hloov hauv 21th exon ntawm cov qog epidermal loj hlob receptor (EGFR) paub tseeb tias siv cov khoom siv pom zoo. los ntawm FDA.Cov tshuaj kuj tseem siv tau zoo hauv kev kho mob HER2-zoo cov neeg mob uas mob qog noj ntshav siab.Afatinib belongs rau ib chav kawm ntawm cov tshuaj hu ua tyrosine kinase inhibitors.Tyrosine kinase inhibitors yog tsim los thaiv qhov kev ua ntawm ib qho enzyme hu ua tyrosine kinase.Cov enzyme no ua lub luag haujlwm loj hauv kev ua haujlwm ntawm cov hlwb, thiab ua haujlwm hauv kev txhawb nqa cov qog loj hlob thiab kev loj hlob.Afatinib ua haujlwm los tiv thaiv kev ua haujlwm ntawm ob hom tyrosine kinases: epidermal growth factor receptor (EGFR) thiab Her2, uas yog "tshaj tawm" los ntawm ntau hom mob qog noj ntshav.Los ntawm thaiv kev ua haujlwm ntawm cov tyrosine kinases, Afatinib tuaj yeem tiv thaiv cov qog nqaij hlav cancer ntawm kev faib thiab loj hlob.