Afatinib Dimaleate CAS 850140-73-7 Purity > 99.5% (HPLC) API

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Lub npe tshuaj: Afatinib Dimaleate

Synonyms: BIBW2992 Dimaleate

CAS: 850140-73-7 Nr

Purity:> 99.0% (HPLC)

Cov tsos mob: Dawb rau Off-White hmoov

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Product Detail

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Nqe lus piav qhia:

Ruifu Chemical Supply Intermediates ntawm Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
Tom ntej: Dimethylamino Acetaldehyde Diethyl Acetal CAS 3616-56-6
Tom ntej: Trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-ib CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS Nr .: 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS Nr .: 314771-88-5

Chemical Properties:

Tshuaj npe	Afatinib Dimaleate
Synonyms	BIBW2992 Dimaleate;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)tab sis-2-Enamide Dimaleate
CAS Nr	618-89-3
CAT Number	Qauv TSIS MUAJ: RF-PI2032
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons
Molecular Formula	C32H33ClFN5O11
Molecular Luj	718.08 ib
rhiab heev	Moisture Sensitive
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Dawb rau Off-White Powder
Purity / Analysis Method	> 99.5% (HPLC)
Poob rau ziab	<0.50%
Residue ntawm Ignition	<0.10%
Qhov siab tshaj plaws ib leeg impurity	<0.30%
Tag nrho cov impurities	<0.50%
Heavy Metals (raws li Pb)	≤ 20ppm
Infrared Spectrum	Raws li tus qauv
NMR	Raws li tus qauv
Test Standard	Enterprise Standard
Txee lub neej	24 Lub Hlis yog khaws cia kom raug
Kev siv	API

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo

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FAQ:

Daim ntawv thov:

Afatinib Dimaleate (CAS: 850140-73-7), dimaleate ntsev daim ntawv ntawm afanitib, yog ib qho tshuaj tiv thaiv kab mob hauv qhov ncauj.Afatinib Dimaleate yog ib qho EGFR tsev neeg inhibitor tsis tuaj yeem nrog IC50s ntawm 0.5 nM, 0.4 nM, 10 nM thiab 14 nM rau EGFRwt, EGFRL858R, EGFRL858R / T790M thiab HER2, raws li.Afatinib Dimaleate yog qhia rau thawj kab kev kho mob ntawm cov neeg mob uas metastatic non-small cell lung cancer (NSCLC) uas nws cov qog muaj epidermal growth factor receptor (EGFR) exon 19 deletions los yog exon 21 (L858R) hloov pauv raws li pom los ntawm FDA- pom zoo kuaj.Yav dhau los, kev kho tus qauv nrog platinum-based chemotherapy doublet regimen tau suav tias yog tus qauv thawj-kab kho rau txhua tus neeg mob nrog NSCLC.Txawm li cas los xij, cov pov thawj tshwm sim tau txheeb xyuas cov neeg nyob hauv qhov kev kho mob uas muaj txiaj ntsig zoo dua, ua rau muaj kev hloov pauv cov tshuaj tshwj xeeb.Afatinib Dimaleate tau tsim los ntawm Boehringer Ingelheim Pharmaceuticals, Afatinib Dimaleate tau pom zoo los ntawm FDA hauv 2013 raws li cov tshuaj menyuam ntsuag nyob rau hauv lub npe lag luam Gilotrif.Afatinib Dimaleate yog chemically synthesized siv cov txheej txheem.Afatinib Dimaleatetsis yog tsuas yog tawm tsam EGFR kev hloov pauv tau tsom los ntawm thawj tiam TKIs zoo li erlotinib lossis gefitinib, tab sis kuj tawm tsam kev hloov pauv xws li T790M uas tsis nkag siab rau cov qauv kev kho no.Vim tias nws cov haujlwm ntxiv tawm tsam Her2, nws tau raug tshuaj xyuas mob qog noj ntshav nrog rau lwm yam EGFR thiab Her2 uas tau tsav cov qog noj ntshav.