Afatinib Dimaleate Intermediate CAS 314771-76-1 Purity > 99.0% (HPLC) Hoobkas

Lus piav qhia luv luv:

Lub npe tshuaj: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1 Nr

Purity:> 99.0% (HPLC)

Cov tsos mob: Lub teeb daj rau daj hmoov

Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Ruifu Chemical Supply Intermediates ntawm Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
Tom ntej: Dimethylamino Acetaldehyde Diethyl Acetal CAS 3616-56-6
Tom ntej: Trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-ib CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS Nr .: 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS Nr .: 314771-88-5

Chemical Properties:

Tshuaj npe	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Synonyms	N4-(3-Chloro-4-Fluorophenyl)-7-[[((3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Afatinib impurity B;Afatinib-des (4-Dimethylamino-2-en-1-oxo) butyl;Des (4-Dimethylamino-2-en-1-oxo)butyl Afatinib
CAS Nr	314771-76-1
CAT Number	Tus Qauv Zauv: RF-PI2028
Tshuag xwm txheej	Hauv Tshuag, Muaj Peev Xwm Ntau Lawm 100MT / Xyoo
Molecular Formula	C18H16ClFN4O2
Molecular Luj	374.8 ib
Boiling Point	559.0 ± 50.0 ℃
Qhov ntom	1.473 ± 0.060 g / cm3
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Lub teeb daj rau daj hmoov
Kev txheeb xyuas	Lub Sijhawm Tuav Pov Hwm ntawm Thawj Tswj Hwm Peak hauv HPLC yuav tsum ua raws li tus qauv
Purity / Analysis Method	> 99.0% (HPLC)
Poob rau ziab	<0.50%
Residue ntawm Ignition	<0.20%
Ib leeg Impurity	<0.50%
Tag nrho cov impurities	<1.00%
Heavy Metals (raws li Pb)	≤ 20ppm
Test Standard	Enterprise Standard
Kev siv	Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo

Qhov zoo:

FAQ:

Daim ntawv thov:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) yog ib qho nruab nrab ntawm Afatinib Dimaleate CAS: 850140-73-7 Nr.Afatinib yog lub thib ob tiam muaj zog thiab irreversible dual inhibitor ntawm lub epidermal loj hlob yam receptor (EGFR) thiab tib neeg epidermal loj hlob receptor 2 (HER2) tyrosine kinase, tsim los ntawm Boehringer Ingelheim, lub teb chaws Yelemees.Nws muaj peev xwm ntawm irreversibly inhibiting kev ua ntawm tyrosine kinase los ntawm kev mus rau Michael cov tshuaj tiv thaiv nrog thiol pawg ntawm cysteine ntawm txoj hauj lwm 797 ntawm EGFR.Muaj nuj nqi: 1. Zoo li Lapatinib thiab Neratinib, Afatinib yog ib qho protein kinase inhibitor uas tseem irreversibly inhibits human epidermal growth factor receptor 2 (Her2) thiab epidermal growth factor receptor (EGFR) kinases.2. Afatinib tsis yog tsuas yog tawm tsam kev hloov pauv ntawm EGFR tsom los ntawm thawj tiam TKIs zoo li erlotinib lossis gefitinib, tab sis kuj tawm tsam kev hloov pauv xws li T790M uas tsis nkag siab rau cov qauv kev kho no.Vim tias nws cov haujlwm ntxiv tawm tsam Her2, nws tau raug tshuaj xyuas mob qog noj ntshav nrog rau lwm yam EGFR thiab Her2 uas tau tsav cov qog noj ntshav.3. Afatinib yog ib yam tshuaj rau thawj kab kev kho mob ntawm cov neeg mob uas txawv hom metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC).Nws ua raws li qhov tsis tuaj yeem hloov pauv covalent inhibitor ntawm receptor tyrosine kinases epidermal growth factor receptor (EGFR) thiab erbB-2 (HER2).