Aripiprazole CAS 129722-12-9 Purity > 99.0% (HPLC) API
Chaw tsim tshuaj paus Supply Intermediates ntawm Aripiprazole Nrog High Purity
Aripiprazole API CAS 129722-12-9
Tom ntej: 1-(2,3-Dichlorophenyl) Piperazine Hydrochloride CAS 119532-26-2
7-Hydroxy-3,4-Dihydro-2(1H)-Quinolinone CAS 22246-18-0
7-(4-Bromobutoxy)-3,4-Dihydro-2(1H)-Quinolinone CAS 129722-34-5
| Tshuaj npe | Aripiprazole |
| Synonyms | 7-[4-[4-(2,3-Dichlorophenyl)-1-Piperazinyl]butoxy]-3,4-Dihydro-2(1H)-Quinolinone |
| CAS Nr | 129722-12-9 |
| CAT Number | Qauv TSIS MUAJ: RF-PI2270 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C23H27Cl2N3O2 |
| Molecular Luj | 448.39 ib |
| Solubility | Insoluble Soluble hauv dej;Insoluble hauv Methanol |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb los yog Yuav luag Dawb Crystalline Hmoov |
| Kev txheeb xyuas | Los ntawm IR;Los ntawm HPLC |
| Solubility | Soluble nyob rau hauv acetic acid, me ntsis soluble nyob rau hauv Ethanol |
| Melting Point | 136.0 ~ 140.0 ℃ |
| Poob rau ziab | <0.50% |
| Residue ntawm Ignition | <0.10% |
| Hnyav Hlau | ≤ 20ppm |
| Residual Solvents | |
| Ethanol | ≤1000ppm |
| DMF | ≤200ppm |
| Yam khoom muaj feem | |
| Ib qho Impurity | <0.20% |
| Tag nrho cov impurities | <1.00% |
| Purity / Analysis Method | > 99.0% (HPLC) |
| Assay | 98.0% ~ 102.0% (raws li Anhydrous Basis) |
| Micro Limits | |
| Tag nrho Aerobic Microbial suav | ≤1000 cfu / g |
| Poov xab thiab pwm ua ke | ≤ 100 cfu / g |
| EColi | Tsis muaj |
| Pathogenic Organizing | Tsis muaj |
| Test Standard | Enterprise Standard |
| Kev siv | API;Antipsychotic |
Pob: Lub raj mis, 5kg / Aluminium tin, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo
Aripiprazole (CAS: 129722-12-9) yog ib yam tshiab ntawm cov lipid soluble quinoline derivatives heev, nws cov tshuaj pharmacological yam ntxwv yog tias nws tsis yog tsuas yog postsynaptic dopamine D2 receptor antagonist, tab sis kuj presynaptic dopamine D2 receptor agonist, nws kuj muaj peev xwm. Excite D1, D3, D4 receptors.Aripiprazole yog ib tiam thib ob atypical antipsychotic thiab anti-depressant nrog ib feem agonist kev ua ntawm dopamine D2 thiab serotonin 5-HT1A receptors thiab antagonist kev ua ntawm serotonin 5-HT2A receptors.Ki qhov tseem ceeb yog 0.34 nM, 0.8 nM, 1.7 nM, thiab 3.4 nM, ntsig txog, rau dopamine D2 thiab D3, serotonin 5-HT1A thiab 5-HT2A receptors.Aripiprazole yog siv los kho tus mob schizophrenia thiab lwm yam kev puas siab puas ntsws.Bristol-Myers Squibb thiab Otsuka Pharmaceutical Company tshaj tawm tias European Union tau pom zoo Abilify (Aripiprazole) hauv kev kho mob ntawm tus mob schizophrenia daim ntawv thov.Schizophrenia cuam tshuam txog 1% ntawm cov pej xeem hauv ntiaj teb, thiab ntau dua rau cov hluas.Schizophrenia cuam tshuam rau kev xav, tswj kev xav thiab kev txiav txim siab ntawm tus neeg mob.Cov neeg mob schizophrenia-zoo yuav muaj cov tsos mob xws li kev hnov lus thiab kev xav tsis zoo, cov neeg mob uas muaj cov tsos mob tsis zoo yog kev sib raug zoo, tsis muaj kev xav hloov.Hauv xyoo 2002 FDA pom zoo Abilify rau kev kho mob ntawm tus mob schizophrenia, uas muaj tsib lub zog: 5 mg, 10 mg, 15 mg, 20 mg thiab 30 mg, txij li nws pom zoo.
