Baloxavir Marboxil CAS 1985606-14-1 API Hoobkas High Quality Featured duab

Baloxavir Marboxil CAS 1985606-14-1 API Hoobkas Zoo

Lus piav qhia luv luv:

Lub npe tshuaj: Baloxavir Marboxil

CAS: 1985606-14-1 Nr

Cov tsos mob: Dawb rau Off-White hmoov

Kev Ntsuas: 98.0% ~ 102.0%

Hauv kev kho mob khaub thuas A thiab Influenza B Infections

Hu rau: Dr. Alvin Huang

Txawb/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Xa email rau peb

Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Baloxavir Marboxil (CAS: 1985606-14-1) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Baloxavir Marboxil,Please contact: alvin@ruifuchem.com

Chemical Properties:

Tshuaj npe	Baloxavir Marboxil
Synonyms	BXM;S-033188
CAS Nr	1985606-14-1
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms
Molecular Formula	C27H23F2N3O7S
Molecular Luj	571.55 ib
Qhov ntom	1.57 ± 0.10g / cm3
Solubility	Soluble hauv DMSO
Kev Cia Lub Sij Hawm Ntev	Khaws lub sijhawm ntev ntawm -20 ℃
COA & MSDS	Muaj
Keeb kwm	Shanghai, Suav
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Dawb rau Off-White Powder
Kev txheeb xyuas	IR Spectrum sib raug rau cov qauv siv Lub sijhawm khaws cia sib raug rau cov qauv siv
Cov ntsiab lus dej (los ntawm KF)	≤ 1.0%
Poob rau ziab	≤ 1.0%
Residue ntawm Ignition	≤0.50%
Hnyav Hlau	≤ 20ppm
Yam khoom muaj feem
Qhov siab tshaj plaws ntawm tus kheej impurity	≤0.50%
Tag nrho cov impurities	≤ 1.0%
Particle Loj	D90 Pass 150um
Chiral Purity	≥99.0%
Purity	≥99.0%
Assay	98.0% ~ 102.0%.
Residual Solvents	Ua raws li ICH Requirements
Kev xa khoom	Shipping Nrog Ice Pack
Test Standard	Enterprise Standard
Kev siv	API, hauv kev kho mob khaub thuas A thiab Influenza B Kab mob

Pob & Cia:

Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.

Qhov zoo:

FAQ:

1985606-14-1 - Daim ntawv thov:

Baloxavir Marboxil (CAS: 1985606-14-1, BXM, S-033188, Xofluza) yog ib qho tshuaj tiv thaiv kab mob uas tsim los ntawm Shionogi Co., lub tuam txhab tshuaj Japanese thiab Roche rau kev kho mob khaub thuas A thiab mob khaub thuas B.Cov tshuaj tau pib pom zoo siv hauv Nyij Pooj thaum Lub Ob Hlis 2018 thiab tau pom zoo los ntawm FDA thaum Lub Kaum Hli 24, 2018 rau kev kho mob khaub thuas tsis sib haum xeeb hauv cov neeg mob hnub nyoog 12 xyoos thiab laus dua uas tau pom zoo tsis pub dhau 48 teev Cov ntawv sau.Baloxavir marboxil, cap-endonuclease inhibitor, muaj cov txheej txheem tshwj xeeb ntawm kev ua haujlwm thaum piv rau cov chav kawm tshuaj neuraminidase inhibitor tam sim no siv los kho cov kab mob khaub thuas.Baloxavir Marboxil yog tshuaj tiv thaiv kab mob khaub thuas tshiab nrog cov txheej txheem tshiab.Baloxavir Marboxil yog cov tshuaj ntawm Baloxavir Acid (S-033447) uas muaj zog thiab xaiv inhibits cap-dependent endonuclease hauv polymerase PA subunit ntawm kab mob khaub thuas A thiab B, ua rau inhibition ntawm RNA transcription thiab replication.Baloxavir kuj tau raug tshuaj xyuas rau nws lub peev xwm los kho COVID-19 tab sis tsis tau pom muaj txiaj ntsig zoo.

1985606-14-1 - Mechanism of Action:

Baloxavir Marboxil yog tus kws kho mob ua npaws, tshwj xeeb, ib qho enzyme inhibitor tsom rau tus kab mob khaub thuas 'cap-dependent endonuclease kev ua, ib qho ntawm cov haujlwm ntawm tus kab mob polymerase complex.Tshwj xeeb, nws inhibits txheej txheem hu ua cap snatching, uas tus kab mob no muab luv luv, capped primers los ntawm tus tswv tsev cell RNA transcripts, uas nws ces siv rau polymerase-catalyzed synthesis ntawm nws xav tau kab mob mRNAs.Ib qho polymerase subunit khi rau tus tswv tsev ua ntej-mRNAs ntawm lawv lub kaus mom 5, tom qab ntawd cov haujlwm polymerase endonuclease catalyzes nws cov cleavage "tom qab 10-13 nucleotides".Yog li ntawd, nws cov txheej txheem yog txawv los ntawm neuraminidase inhibitors xws li Oseltamivir thiab Zanamivir.

1985606-14-1 - Pharmacokinetics:

Baloxavir Marboxil yog ib qho tshuaj tiv thaiv kab mob khaub thuas cap-dependent endonuclease uas tiv thaiv kev ua haujlwm ntawm polymerase thiab yog li ntawd tus kab mob khaub thuas mRNA replication 5, 3. Nws tau qhia txog kev siv tshuaj tiv thaiv kab mob khaub thuas A thiab B kab mob, nrog rau cov kab mob uas tiv taus cov tshuaj tiv thaiv kab mob tam sim no 1. Cov tshuaj no inhibits ib qho enzyme uas yuav tsum tau rau tus kab mob replication, yog li sai kho tus kab mob khaub thuas 5, Label thiab alleviating cov tsos mob ntawm tus kab mob.Ib koob tshuaj ntawm tus neeg sawv cev no tau pom tias yog qhov zoo tshaj rau cov placebo hauv kev txo cov tsos mob khaub thuas thiab zoo dua rau ob qho tib si oseltamivir thiab cov tshuaj placebo hauv cov txiaj ntsig ntawm virologic (cim los ntawm cov kab mob tsawg zuj zus).

1985606-14-1 - Cov lus qhia:

Baroxavir yog tsim rau cov neeg mob ≥ 12 xyoos uas raug mob los ntawm tus mob khaub thuas tsis sib haum xeeb thiab nws cov tsos mob tsis pub dhau 48 teev.Kev saib xyuas yuav tsum tau them rau cov kev txwv ntawm cov tshuaj: tus kab mob khaub thuas hloov lub sij hawm, thiab muaj ntau yam xws li hom kab mob thiab subtype.Thaum cov tshuaj tiv thaiv ntawm tus kab mob thiab cov pathogenicity ntawm tus kab mob hloov, qhov kev kho mob ntawm cov tshuaj tiv thaiv kab mob yuav tsis muaj zog.Thaum txiav txim siab seb puas yuav noj basalovir dipivoxil, cov ntaub ntawv muaj nyob ntawm qhov rhiab heev ntawm cov kab mob sib kis hauv zos rau cov tshuaj yuav tsum tau txiav txim siab.

1985606-14-1 - Siv:

Baloxavir Marboxil yog cov tshuaj tiv thaiv kab mob khaub thuas, tshuaj tiv thaiv kab mob, uas tau noj ib zaug ib ntsiav tshuaj, los ntawm qhov ncauj, los ntawm cov neeg muaj hnub nyoog 12 xyoos lossis laus dua, uas tau nthuav tawm cov tsos mob ntawm tus kab mob no tsis pub dhau 48 teev. baloxavir marboxil siv tom qab 48 teev tsis tau kuaj.

1985606-14-1 - Contraindications:

Baloxavir Marboxil yuav tsum tsis txhob siv nrog cov khoom noj siv mis, cov dej haus calcium uas muaj zog, lossis cov tshuaj laxatives, antacids, los yog cov tshuaj hauv qhov ncauj uas muaj calcium, hlau, magnesium, selenium, txhuas lossis zinc.

1985606-14-1 - Cov teebmeem:

Cov kev mob tshwm sim tshwm sim tom qab ib koob tshuaj ntawm baloxavir marboxil suav nrog raws plab, mob ntsws, mob khaub thuas, mob taub hau, thiab xeev siab.Cov xwm txheej tsis zoo tau tshaj tawm hauv 21% ntawm cov neeg tau txais baloxavir, 25% ntawm cov neeg tau txais cov placebo, thiab 25% ntawm Oseltamivir.

1985606-14-1 - Kev Npaj:

Japanese patent JP6212678 qhia txog cov txheej txheem synthesis ntawm Baloxavir Marboxil.3, 4-difluorobenzoic acid tau siv los ua cov khoom siv raw los ua rau DMF raws li kev ua ntawm LDA kom tau 2-formyl-3, 4-difluorobenzoic acid.Tom qab ntawd nws tsim thioacetal nrog thiophenol, tom qab ntawd nws txo qis thiab sib cais nrog borane kom tau 2-phenylthiomethyl -3, 4-difluorob, 8-difluorodibenzo [B, e] thiazepine -11(6H)-ib qho, thiab thaum kawg yog qhov tseem ceeb thiazepine tawg. 7, 8-difluoro-6,11-dihydrodibenzo [B, e] thiazepine -11-cawv yog tau los ntawm kev txo cov sodium borohydride.Siv 3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid los teb nrog tert-butyl formate tom qab esterification kom tau 3-(benzyloxy)-1-((tert-butoxycarbonyl) amino) -4-oxo -1, 4-dihydropyridine-2-methyl formate hydrate, thiab tom qab ntawd nrog 2-(2, 2-dimethoxyethoxy) ethylamine tau txais cov tshuaj tiv thaiv urethane, thiab tom qab ntawd cyclizes nyob rau hauv qhov kev txiav txim ntawm methanesulfonic acid kom tau 7-(benzyloxy)-3, 4,12,12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyridino [2,1-f][1,2,4] triazine -6, 8-dione hemihydrate, ces nws yog condensed nrog (R)-tetrahydrofuran -2-formic acid, ces crystallized thiab daws, thiab ces cov chiral auxiliary pab pawg neeg raug tshem tawm kom tau cov chiral niam txiv nplhaib molecule tseem ceeb (R)-7-(benzyloxy)-3,4,12, 12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyrido [2,1-f][1,4] Triazine-6, 8-dione.Tom qab ntawd tus niam txiv lub nplhaib tseem ceeb yog siv los pauv nrog n-hexanol nyob rau hauv qhov kev txiav txim ntawm Grignard reagent, thiab tom qab ntawd nrog cov ntsiab lus thiazepine fragment 7,8-difluoro-6, 11-dihydrodibenzo [B, e] thiazepine -11-cawv docking. , thiab thaum kawg debutylation thiab condensation nrog methyl chloroformate kom tau txais cov khoom kawg Baloxavir Marboxil.