Betamethasone CAS 378-44-9 Purity 97.0% ~ 103.0% API Hoobkas High Purity

Lus piav qhia luv luv:

Lub npe tshuaj: Betamethasone

CAS: 378-44-9 Nr

Cov tsos mob: Dawb los yog yuav luag dawb crystalline hmoov

Purity: 97.0% ~ 103.0% ntawm C22H29FO5, ntawm qhuav hauv paus

API High Quality, Commercial Production

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E-Mail: alvin@ruifuchem.com

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Product Detail

Yam khoom

Khoom cim npe

378-44-9 - Nqe lus piav qhia:

Kev muag khoom muag Betamethasone nrog High Purity thiab ruaj khov zoo
Lub npe tshuaj: Betamethasone
CAS: 378-44-9 Nr

378-44-9 : kuv.Chemical Properties:

Tshuaj npe	Betamethasone
Synonyms	Betamethasone Base;9alpha-Fluoro-16beta-Methylprednisolone;9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione;(11beta,16alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
CAS Nr	378-44-9 : kuv
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons
Molecular Formula	C22H29FO5
Molecular Luj	392.47 ib
Melting Point	235.0 ~ 237.0 ℃
Shipping Condition	Nyob rau hauv Ambient Kub
COA & MSDS	Muaj
Hom	Ruifu Tshuaj

378-44-9 : kuv.Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Dawb los yog Yuav luag Dawb Crystalline Hmoov
Kev Taw Qhia A	Infrared Absorption
Kev Qhia B	Thin-Layer Chromatographic Identification Test
Specific Optical Rotation	+ 118.0 ° txog + 126.0 ° (Xam ntawm lub hauv paus qhuav)
Tus kheej impurity	≤ 1.00%
Tag nrho cov impurities	≤ 2.00%
Residual Solvents Methanol	≤3000ppm
Residual Solvents Chloroform	≤60ppm
Poob rau ziab	≤0.50% (Nyob ntawm 105 ℃, 3 teev)
Residue ntawm Ignition	≤ 0.20%
Purity / Analysis Method	97.0% ~ 103.0% ntawm C22H29FO5 Xam rau ntawm Kev Qhuab Qhia
Test Standard	Suav Pharmacopoeia (CP);EP10.0 thiab USP 42
Ntim thiab Cia	Khaws rau hauv cov thawv ntim nruj.Khaws ntawm 2 ℃ thiab 30 ℃ .
Daim ntawv thov	Active Pharmaceutical Ingredients (API)

Pob & Cia:

Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov txias, qhuav (2 ~ 30 ℃) thiab lub tsev tso cua kom zoo kom deb ntawm cov khoom tsis sib xws.Nyob deb ntawm lub teeb muaj zog thiab cua sov, noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.

Qhov zoo:

FAQ:

378-44-9 - Kev pheej hmoo thiab kev nyab xeeb:

Risk Codes R40 - Cov pov thawj txwv tsis pub muaj cov nyhuv carcinogenic
R48/20/21 -
R61 - Tej zaum yuav ua rau muaj mob rau tus menyuam hauv plab
Safety Description S22 - Tsis txhob ua pa plua plav.
S36 - Hnav khaub ncaws tiv thaiv zoo.
S45 - Thaum muaj xwm txheej lossis yog tias koj tsis xis nyob, nrhiav kev kho mob tam sim ntawd (qhia daim ntawv lo thaum twg los tau.)
S53 - Tsis txhob raug - tau txais cov lus qhia tshwj xeeb ua ntej siv.
WGK Germany 2
RTECS TU 4000000
HS Code 2937229000
Toxicity LD50 qhov ncauj hauv nas:> 4500mg / kg

378-44-9 : kuv.Daim ntawv thov:

Betamethasone (CAS: 378-44-9), belongs rau adrenal corticosteroids, nws yog ib tug isomer ntawm dexamethasone, thiab lub luag hauj lwm ntawm betamethasone zoo ib yam li prednisolone thiab dexamethasone, nws muaj anti-inflammatory, anti-rheumatic, anti-allergic thiab suppression. ntawm lub cev tiv thaiv kab mob thiab lwm yam tshuaj muaj txiaj ntsig, nws cov tshuaj tiv thaiv kab mob muaj zog dua li dexamethasone, triamcinolone, hydrocortisone thiab lwm yam, nws tuaj yeem txo thiab tiv thaiv cov ntaub so ntswg rau o thiab tshem tawm cov cua sov, liab thiab o ntawm lub zos tsis muaj kab mob, yog li txo. Kev ua haujlwm ntawm o, tiv thaiv kev ua haujlwm ntawm cov khoom no 0.3mg yog sib npaug rau dexamethasone 0.75mg, prednisone 5mg lossis 25mg cortisone.Betamethasone sodium retention effect yog ib puas npaug ntau dua li hydrocortisone, nyob rau hauv thawj qhov kev ua haujlwm ntawm adrenal hypofunction, nws tuaj yeem siv ua ke nrog glucocorticoid rau kev hloov kho, thiab nws yog siv rau kev tiv thaiv lossis inhibiting cell-mediated immune teb, ncua kev tsis haum tshuaj thiab txo qhov kev tiv thaiv thawj zaug. teb nthuav dav, nws yog siv rau qis renin thiab qis aldosterone syndrome thiab autonomic neuropathy induced orthostatic hypotension.Tam sim no betamethasone kuj tseem siv rau kev kho mob rheumatoid mob caj dab, mob caj dab rheumatoid, lupus, mob ntsws asthma hnyav, mob dermatitis, mob leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, thiab pruritus thiab kev kho mob.Cov khoom no yog contraindicated nyob rau hauv lub mob loj heev keeb kwm, active duodenal rwj, gastrointestinal anastomosis tsis ntev los no, hnyav osteoporosis, overt mob ntshav qab zib, mob siab heev, kab mob, kab mob, fungal kab mob uas tsis tswj los ntawm kev siv cov tshuaj tua kab mob, thrombophlebitis, daim tawv nqaij kab mob. raws li impetigo, tinea, jock khaus thiab lwm yam.

378-44-9 - USP35 Txuj:

Betamethasone
C22 H29FO5 392.46
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11,16)-.
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione [378-44-9].
Betamethasone muaj tsis pub tsawg tshaj 97.0 feem pua thiab tsis ntau tshaj 103.0 feem pua ntawm C22H29FO5, xam nyob rau hauv qhuav.
Ntim thiab khaws cia-Txuag hauv cov thawv nruj.Khaws ntawm 2 ℃ thiab 30 ℃.
USP Reference cov qauv <11>-
USP Betamethasone RS
Kev txheeb xyuas-
A: Infrared Absorption <197M>.
B: Thin-Layer Chromatographic Identification Test <201>-
Kuaj cov tshuaj-Npaj cov tshuaj Betamethasone hauv cov dej cawv uas muaj 0.5 mg rau ib mL.
Tsim cov kuab tshuaj: sib tov ntawm chloroform thiab diethylamine (2: 1).
Cov txheej txheem-Ua raws li tau hais hauv tshooj, tshwj tsis yog txhawm rau nrhiav cov pob zeb los ntawm maj mam txau nrog dilute sulfuric acid (1 nyob rau hauv 2) thiab cua sov rau ntawm lub phaj kub lossis hauv qab lub teeb kom txog thaum cov pob zeb tshwm.
Kev sib hloov tshwj xeeb <781S>: nruab nrab ntawm +118 thiab +126, suav ntawm lub hauv paus qhuav.
Kev ntsuas tshuaj: 5 mg rau ib mL, hauv methanol.
Poob ntawm ziab 731-Sry nws ntawm 105 rau 3 teev: nws poob tsis ntau tshaj 1.0% ntawm nws qhov hnyav.
Residue ntawm ignition 281: tsis ntau tshaj 0.2%, platinum crucible siv.
Ordinary impurities 466-
Kev daws teeb meem: methanol.
Standard tov: methanol.
Daim ntawv ntim: 10 µL.
Eluant: sib tov ntawm toluene, acetone, methyl ethyl ketone, thiab formic acid (55: 20: 20: 5), nyob rau hauv ib tug nonnequilibrated chamber.
Visualization: 5.
Assay-
Txawb theem-Npaj lim thiab degassed sib tov dej thiab acetonitrile (63:37).Hloov kho yog tias tsim nyog (saib System Suitability hauv Chromatography 621).
Cov txheej txheem sab hauv-Npaj ib qho kev daws ntawm propylparaben hauv cawv uas muaj cov ntsiab lus paub txog 0.25 mg ib mL.
Cov txheej txheem kev npaj-Dissolve ib qho hnyav hnyav ntawm USP Betamethasone RS hauv cawv kom tau txais cov tshuaj uas muaj cov ntsiab lus paub txog 0.2 mg ib mL.Hloov 10.0 mL ntawm cov tshuaj no mus rau ib lub vial uas tsim nyog, thiab ntxiv 10.0 mL ntawm Internal standard tov, kom tau ib tug Standard kev npaj uas paub ntau npaum li cas ntawm 0.1 mg ntawm betamethasone thiab txog 0.125 mg ntawm propylparaben ib mL.
Kev tshuaj ntsuam xyuas-Siv txog 80 mg ntawm Betamethasone, ntsuas kom raug, npaj raws li qhia rau kev npaj.
Chromatographic system (saib Chromatography 621)-Cov kua chromatograph yog nruab nrog 240-nm ntes thiab 4.6-mm × 25-cm kem uas muaj cov ntim L1.Tus nqi ntws yog li 1.0 mL ib feeb.Chromatograph tus txheej txheem npaj, thiab sau cov lus teb ncov raws li qhia rau Cov Txheej Txheem: cov sij hawm tuav cov txheeb ze yog kwv yees li 1.0 rau betamethasone thiab 1.4 rau propylparaben;qhov kev daws teeb meem, R, nruab nrab ntawm betamethasone thiab propylparaben tsis tsawg dua 3.0;thiab tus txheeb ze tus qauv sib txawv rau kev txhaj tshuaj replicate tsis ntau tshaj 2.0%.
Cov txheej txheem-Kev txhaj tshuaj sib npaug (kwv yees li 10 µL) ntawm Cov Txheej Txheem Kev Npaj thiab Kev Ntsuas Kev Ntsuas rau hauv cov chromatograph, sau cov chromatograms, thiab ntsuas cov lus teb rau cov peaks loj.Xam qhov ntau, hauv mg, ntawm C22H29FO5 hauv feem ntawm Betamethasone coj los ntawm cov mis:
800C (RU / RS)
nyob rau hauv uas C yog qhov concentration, nyob rau hauv mg ib mL, ntawm USP Betamethasone RS nyob rau hauv tus txheej txheem npaj;thiab RU thiab RS yog qhov siab tshaj qhov sib piv ntawm betamethasone ncov thiab cov txheej txheem sab hauv lub ncov tau txais los ntawm Assay npaj thiab Standard npaj, feem.