Bortezomib CAS 179324-69-7 Purity ≥99.0% (HPLC) API Hoobkas High Purity
Muab Bortezomib Related Intermediates nrog High Purity
1S,2S,3R,5S)-(+)-2,3-Pinadiol CAS 18680-27-8
1R,2R,3S,5R)-(-)-2,3-Pinadiol CAS 22422-34-0
Bortezomib CAS 179324-69-7
| Tshuaj npe | Bortezomib |
| Synonyms | Velcade, MG-341, PS-341 |
| CAS Nr | 179324-69-7 |
| CAT Number | RF-API 65 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
| Molecular Formula | C19H25BN4O4 |
| Molecular Luj | 384.24 ib |
| Melting Point | 122.0 ~ 124.0 ℃ |
| Qhov ntom | 1.214 ib |
| Refractive Index | 1.564 ib |
| Solubility | Soluble hauv Chloroform, DMSO, Ethanol thiab Methanol |
| Kev ruaj ntseg | Hygroscopic thiab Moisture Sensitive |
| Shipping Condition | Shipped nyob rau hauv ambient kub |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb los yog Off-White hmoov |
| Purity / Analysis Method | ≥99.0% (HPLC) |
| Poob rau ziab | ≤0.50% |
| Residue ntawm Ignition | ≤ 0.20% |
| Kev hloov kho qhov muag | -41.0° ~ -46.0° |
| Hnyav Hlau | ≤ 20ppm |
| Acidity | 4.0 ~ 7.0 |
| Isomer | ≤0.50% |
| Ib leeg Impurity | ≤0.50% |
| Tag nrho cov impurities | ≤ 1.0% |
| Residual Solvents | |
| Methanol | ≤ 0.30% |
| Dichloromethane | ≤ 0.05% |
| Hexane | ≤ 0.02% |
| Ethyl Acetate | ≤0.50% |
| Test Standard | Enterprise Standard |
| Kev siv | API |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard Nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab chaw muag khoom ntawm Bortezomib (CAS: 179324-69-7) nrog cov khoom zoo, API.
Bortezomib, muag raws li lub npe Velcade ntawm lwm tus, yog cov tshuaj tiv thaiv kab mob uas siv los kho ntau yam myeloma thiab mantle cell lymphoma.Bortezomib tau pom zoo siv rau kev kho mob hauv Tebchaws Meskas hauv xyoo 2003 thiab hauv European Union xyoo 2004. Nws yog nyob rau hauv World Health Organization's List of Essential Medicines.Bortezomib yog thawj tus proteasome inhibitor uas tau pom zoo los ntawm US FDA rau ntau yam myeloma, ntshav qog ntshav.Ib tug thim rov qab inhibitor ntawm 26S proteasome-ib lub thoob-zoo li cov kab ntau cov protein pom nyob rau hauv cov nucleus thiab cytosol ntawm tag nrho cov hlwb eukaryotic.Bortezomib yog ib qho kev xaiv thiab muaj zog 26S proteasome inhibitor, uas yog boronic acid dipeptide derivative.Tib neeg txoj kev tshawb fawb txog qog nqaij hlav qog noj ntshav qhia tau tias Bortezomib inhibit PKR-zoo li endoplasmic reticulum (ER) kinase thiab txhim kho ER kev ntxhov siab, ua rau apoptosis.
