Candesartan Cilexetil CAS 145040-37-5 Purity > 99.0% (HPLC) API Hoobkas

Lus piav qhia luv luv:

Lub npe tshuaj: Candesartan Cilexetil

CAS: 145040-37-5 Nr

Purity:> 99.0% (HPLC)

Cov tsos mob: Dawb rau Off-White Crystalline Hmoov

Ib qho Selective Angiotensin II Receptor Antagonist

API High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com

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Product Detail

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Khoom cim npe

Nqe lus piav qhia:

Ruifu Chemical Supply Candesartan Cilexetil Intermediate Nrog Siab Purity
Candesartan Cilexethyl CAS 145040-37-5
Candesartan CAS 139481-59-7
1-Chloroethyl Cyclohexyl Carbonate CAS 99464-83-2
Candesartan Cilexetil Intermediate Eethyl Ester C6 CAS 139481-41-7
Candesartan Cilexetil Intermediate CAS 139481-44-0
Trityl Candesartan Cileexetil CAS 170791-09-0

Chemical Properties:

Tshuaj npe	Candesartan Cilexeth
Synonyms	TCV-116;1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H benzo[d]imidazole-7-Carboxylate
CAS Nr	145040-37-5
CAT Number	Qauv: RF-PI1891
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons
Molecular Formula	C33H34N6O6
Molecular Luj	610.66 ib
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Dawb rau Off-White Crystalline Hmoov
Kev txheeb xyuas HPLC	Lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm tus qauv sib raug rau qhov hauv chromatogram tau nrog tus qauv
Identification IR	IR infrared absorption spectrum yog zoo ib yam li Candesartan Cilexetil siv tus qauv
Clarity thiab xim daws	Cov tshuaj hauv chloroform ntawm 5% yog ntshiab thiab tsis muaj xim
Purity / Analysis Method	> 99.0% (HPLC)
Melting Point	155.0 ~ 160.0 ℃
Poob rau ziab	<0.30%
Residue ntawm Ignition	<0.10%
Hnyav Hlau	<10ppm
Arsenic (As)	<1 ppm
Particle Loj Distribution	90% <30μm
Organic impurities	los ntawm HPLC
Ethyl Candesartan	<0.15%
Desethyl Candesartan	<0.15%
N2-Ethyl Candesartan Cilexei	<0.15%
Tej yam tsis paub impurity	<0.15%
Tag nrho cov impurities	<0.60%
Kev ntsuam xyuas los ntawm Potentiometry	99.0 ~ 101.0% ntawm C33H34N6O6, xam rau ntawm cov khoom tsis muaj dej
Organic Volatile impurity
Methano	<0.30%
Ethanol	<0.50%
Diethyl Ether	<0.50%
Aceton	<0.50%
Dichloromethan	<0.06%
Dimethylformamide	<0.088%
Microbiological Contarination
Tag nrho Aerobic Microbial suav	<1000cfu/g
Moulds & Poov xab	<100cfu/g
E. Coli	Tsis muaj
Salmonella	Tsis muaj
Test Standard	Enterprise Standard
Kev siv	API;Antihypertensive Agent

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo

Qhov zoo:

FAQ:

Daim ntawv thov:

Candesartan Cilexetil (TCV-116) (CAS: 145040-37-5) yog angiotensin II receptor antagonist nrog IC50 ntawm 0.26 nM, siv rau kev kho mob ntshav siab.Candesartan yog ib qho angiotensin-receptor blocker (ARB) uas yuav siv tau ib leeg lossis nrog lwm tus neeg ua haujlwm los kho ntshav siab.Nws yog siv nyob rau hauv qhov ncauj raws li prodrug, candesartan cilexetil, uas yog sai hloov mus rau nws active metabolite, candesartan, thaum nqus nyob rau hauv lub plab hnyuv ib ntsuj av.Candesartan txo cov ntshav siab los ntawm antagonizing renin-angiotensin-aldosterone system (RAAS);Nws sib tw nrog angiotensin II rau kev khi rau hom-1 angiotensin II receptor (AT1) subtype thiab tiv thaiv cov ntshav siab nce los ntawm angiotensin II.Tsis zoo li angiotensin-hloov enzyme (ACE) inhibitors, ARBs tsis muaj qhov tsis zoo ntawm hnoos qhuav.Candesartan tuaj yeem siv los kho cov ntshav siab, cais tawm systolic hypertension, sab laug ventricular hypertrophy thiab ntshav qab zib nephropathy.Nws kuj tseem siv tau los ua lwm tus neeg sawv cev rau kev kho mob plawv tsis ua haujlwm, systolic tsis ua haujlwm, myocardial infarction thiab kab mob plawv.