Carvedilol CAS 72956-09-03 Purity > 99.0% (HPLC)

Lus piav qhia luv luv:

Lub npe tshuaj: Carvedilol

CAS: 72956-09-03 Nr

Purity:> 99.0% (HPLC)

Cov tsos mob: Dawb crystalline hmoov

Hu rau: Dr. Alvin Huang

Txawb/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Carvedilol (CAS: 72956-09-03) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Carvedilol,Please contact: alvin@ruifuchem.com

Muaj feem cuam tshuam:

Related Intermediates ntawm Carvedilol

N-(2-(2-Methoxyphenoxy)ethyl)benzylamine Hydrochloride	CAS: 3246-03-5 Nr
2-(2-Methoxyphenoxy) ethylamine Hydrochloride Hydrate	CAS 64464-07-9 Nr
2- (2-Methoxyphenoxy) ethylamine	CAS Nr .: 1836-62-0
4-(2,3-Epoxypropoxy) carbazole	CAS 51997-51-4 Nr
4-Hydroxycarbazole	CAS Nr .: 52602-39-8
1,3-Cyclohexanedione	CAS 504-02-9 Nr
Carvedilol	CAS 72956-09-03 Nr
Carvedilol Phosphate Hemihydrate	CAS Nr .: 610309-89-2

Chemical Properties:

Tshuaj npe	Carvedilol
Synonyms	1-(9H-Carbazol-4-yloxy)-3-[[2-(2-Methoxyphenoxy)ethyl]amino]-2-Propanol;Tus kws kos duab;Cadilan;Carca;Cardivas;Carloc;Carvas;Carvedilol;Carvediol;Coreg;DQ 2466;Dilatrend;Dimitone;Eucardic;Korvasan;Kredex;Querto;Talliton;IB-14190
Tshuag xwm txheej	Hauv Tshuag, GMP Kev Lag Luam
CAS Nr	72956-09-3
Molecular Formula	C24H26N2O4
Molecular Luj	406,48 g / mol
Melting Point	115.0 txog 119.0 ℃
Qhov ntom	1.250 ± 0.06g / cm3
Solubility hauv dej	Insoluble hauv dej
Solubility	Soluble hauv Methanol.Me ntsis Soluble hauv Ethanol, Ether
Cia Temp.	Qhov chaw txias & qhuav (2 ~ 8 ℃)
COA & MSDS	Muaj
Hom	Ruifu Tshuaj

Specifications:

Cov khoom	Kev soj ntsuam Standards	Cov txiaj ntsig
Qhov tshwm sim	Dawb Crystalline hmoov	Ua raws
Poob rau ziab	≤0.50% (105 ℃ rau 3 h)	0.25%
Residue ntawm Ignition	≤0.10%	0.07%
Yam khoom muaj feem
Tag nrho cov impurities	≤0.50%	Ua raws
impurity A	≤ 0.20%	Ua raws
Cov impurity C	≤ 0.02%	Ua raws
Lwm Tus Neeg Tsis Pom Zoo	≤0.10%	Ua raws
Heavy Metals (Pb)	≤10ppm	<10ppm
Purity / Analysis Method	> 99.0% (HPLC)	99.72%
Infrared Spectrum	Raws li tus qauv	Ua raws
Xaus	Cov khoom tau raug kuaj & ua raws li cov specifications

Pob / Cia /Kev xa khoom:

Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv lub thawv kaw nruj nreem.Khaws rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.

Qhov zoo:

Muaj peev xwm txaus: Muaj cov chaw txaus thiab cov kws tshaj lij

Kev Pabcuam Kev Ua Haujlwm: Ib qho kev pabcuam kev yuav khoom

Pob OEM: Kev cai pob thiab daim ntawv lo muaj

Kev xa khoom sai: Yog tias nyob hauv Tshuag, peb hnub xa khoom lav

Stable Supply: Khaws cov khoom tsim nyog

Kev them nyiaj yug Technical: Technology tov muaj

Kev Pabcuam Synthesis: Ntau yam ntawm grams mus rau kilos

High Quality: Tsim kom muaj kev ruaj ntseg zoo

FAQ:

Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.

Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.

Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.

ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.

Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.

Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.

MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.

Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.

Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.

Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.

Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.

Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.

72956-09-3 - Cov Ntaub Ntawv Kev Nyab Xeeb:

Hazard Codes N, Xn
Nqe Lus Tshaj Tawm 51/53-36/37/38-20/21/22
Cov Lus Qhia Txog Kev Nyab Xeeb 61-36-26
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS UA8670000
HazardClass IRRITANT
PackingGroup III
Cov Ntaub Ntawv Muaj Xwm Ceev 72956-09-3 (Cov Ntaub Ntawv Tshuaj Tiv Thaiv)
Toxicity LD50 qhov ncauj hauv dev:> 1gm / kg

72956-09-3 - PebDaim ntawv thov:

Carvedilol (CAS: 72956-09-03) yog vasodilating beta-blocker pab tau rau kev kho mob ntshav siab thiab angina pectoris.Ntxiv nrog rau kev txo cov ntshav siab, carvedilol txo qis tag nrho cov vascular tsis kam yam tsis muaj reflex tachycardia feem ntau tshwm sim nrog vasodilators.Nws tau raug tshaj tawm tias ua tau zoo nrog rau lub raum sparing teebmeem.

Carvedilol tau tsim thawj zaug hauv Belgium hauv xyoo 1985. Cov khoom no tuaj yeem thaiv cov alpha thiab beta receptors, tsis muaj kev ua haujlwm hauv lub cev, hauv cov ntsiab lus siab ntawm kev zam nrog calcium antagonism.Nws muaj cov txiaj ntsig zoo ntawm kev thaiv cov beta receptors, uas tuaj yeem nthuav dav cov hlab ntsha, txo qis peripheral tsis kam thiab txo cov ntshav siab, thiab muaj kev cuam tshuam me ntsis ntawm cov zis thiab lub plawv dhia.Kev kho mob tuaj yeem siv rau thawj qhov kub siab thiab angina pectoris.

72956-09-3 - USP 35 Txuj:

DEFINITION

Carvedilol muaj NLT 98.0% thiab NMT 102.0% ntawm C24H26N2O4, suav ntawm lub hauv paus qhuav.

IDENTIFICATION

• A. Infrared Absorption <197K>

• B. Lub sij hawm khaws cia ntawm lub ncov loj ntawm cov qauv kev daws teeb meem sib raug rau cov txheej txheem kev daws teeb meem, raws li tau txais hauv Assay.

QHIA

• Cov txheej txheem

Tsis muaj: 2.72 g / L ntawm monobasic potassium phosphate.Kho nrog dilute phosphoric acid rau pH ntawm 2.0.

Mobile theem: Acetonitrile thiab Buffer (31:69)

Kev daws teeb meem tsim nyog: 0.05 mg / mL txhua ntawm USP Carvedilol RS thiab USP Carvedilol Related Compound A RS hauv theem txawb

Kev daws teeb meem: 0.04 mg / mL ntawm USP Carvedilol RS nyob rau theem txawb

Cov qauv kev daws teeb meem: 0.04 mg / mL ntawm Carvedilol nyob rau theem Mobile

Chromatographic system

(Saib Chromatography <621>, System Suitability.)

Qauv: LC

Detector: UV 240 nm

Kem: 4.6-mm × 15-cm;5-µm ntim L7

Kem kub: 55 ℃

Tus nqi ntws: 1 mL / min

Lub sijhawm ua haujlwm: 60 min

Kev txhaj tshuaj loj: 10 µL

Qhov system haum

Qauv: Kev daws teeb meem tsim nyog

Suitability xav tau

Kev daws teeb meem: NLT 4.0 ntawm carvedilol thiab carvedilol ntsig txog compound A

Tailing factor: NMT 1.5 rau lub ncov carvedilol

Tus nqi sib txawv: NMT 2%

Kev tsom xam

Qauv: Cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem

Xam cov feem pua ntawm carvedilol (C24H26N2O4) nyob rau hauv ib feem ntawm cov qauv coj mus kuaj:

Result = (rU/rS) × (CS/CU) × 100

rU =	Cov lus teb ncov ntawm carvedilol los ntawm cov qauv tshuaj
rS =	Peak teb ntawm carvedilol los ntawm Standard tov
CS =	Cov ntsiab lus ntawm carvedilol hauv Standard tov (mg / mL)
CU =	Qhov concentration ntawm Carvedilol nyob rau hauv cov tshuaj Sample (mg / mL)

Kev lees paub: 98.0% -102.0% ntawm lub hauv paus qhuav

IMPURITIES

• Residue ntawm Ignition <281>: NMT 0.1% ntawm 1 g

• Heavy Metals, Method II <231>: NMT 10 ppm

• Organic Impurities, Txheej Txheem 1: [Ceeb Toom-Rau lub hauv paus ntawm cov impurities tam sim no, ua Organic Impurities, Txheej Txheem 1 lossis Organic Impurities, Txheej Txheem 2. Organic Impurities, Txheej Txheem 2 raug pom zoo thaum carvedilol ntsig txog F yog qhov muaj peev xwm impurity.]

Buffer thiab Txawb theem: Npaj raws li qhia hauv Assay.

Kev daws teeb meem tsim nyog: 0.05 mg / mL txhua ntawm USP Carvedilol RS thiab USP Carvedilol Related Compound C RS nyob rau theem txawb

Kev daws teeb meem: 1 µg / mL txhua ntawm USP Carvedilol RS, USP Carvedilol Related Compound A RS, USP Carvedilol Related Compound B RS, USP Carvedilol Related Compound D RS, thiab USP Carvedilol Related Compound E RS, thiab 0.2 µg / mL ntawm USP Carvedilol Related Compound C RS nyob rau theem txawb

Cov qauv kev daws teeb meem: 1 mg / mL ntawm Carvedilol nyob rau theem Mobile

Chromatographic system

(Saib Chromatography <621>, System Suitability.)

Qauv: LC

Ntes: Dual wavelength, UV 220 thiab 240 nm.Siv 220 nm rau quantitating carvedilol muaj feem xyuam nrog E, thiab siv 240 nm rau carvedilol thiab tag nrho lwm yam sib txuas.

Kem: 4.6-mm × 15-cm;5-µm ntim L7

Kem kub: 55 ℃

Tus nqi ntws: 1 mL / min

Kev txhaj tshuaj loj: 20 µL

Qhov system haum

Qauv: Kev daws teeb meem tsim nyog

Suitability xav tau

Kev daws teeb meem: NLT 17 ntawm carvedilol thiab carvedilol muaj feem xyuam nrog C

Kev tsom xam

Qauv: Cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem

Xam cov feem pua ntawm carvedilol ntsig txog compound A, carvedilol ntsig txog compound B, carvedilol ntsig txog compound C, carvedilol ntsig txog compound D, carvedilol ntsig txog compound E, thiab lwm tus neeg impurity nyob rau hauv feem ntawm Carvedilol noj:

Result = (rU/rS) × (CS/CU) × 100

rU	=	cov lus teb ncov ntawm cov khoom sib txuas los yog lwm yam impurity los ntawm Cov Qauv Tshuaj
rS	=	cov lus teb ncov ntawm qhov sib txuas muaj feem cuam tshuam los ntawm Standard tov.Txhawm rau xam qhov feem pua ntawm lwm tus neeg impurity siv lub ncov teb ntawm carvedilol.
CS	=	Kev sib xyaw ua ke ntawm cov tshuaj sib xyaw ua ke hauv Standard tov (mg / mL).Txhawm rau xam qhov feem pua ntawm lwm yam impurities rau CS, siv qhov concentration ntawm USP Carvedilol RS.
CU	=	Qhov concentration ntawm Carvedilol nyob rau hauv cov tshuaj Sample (mg / mL)

Kev lees txais: Saib Table 1.

Table 1

Lub npe	Lub Sijhawm Retention Relative	Kev lees paub, NMT (%)
Carvedilol muaj feem xyuam nrog Ea	0.35 Nws	0.1
Carvedilol muaj feem xyuam nrog Ab	0.52 ib	0.1
Carvedilol bisalkylpyrocatechol derivative (yog muaj)c	0.70 ib	0.15
Carvedilol	1.0	—
Carvedilol muaj feem xyuam nrog Cd	3.6	0.02 ib
Carvedilol muaj feem xyuam nrog De	5.0	0.1
Carvedilol muaj feem xyuam nrog Bf	8.5	0.1
Lwm tus neeg impurity	-	0.10
Tag nrho impurities	-	0.5g
2-(2-Methoxyphenoxy) ethyl amine. b 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamine)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2 -ol. c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy)) propan-2-ol). d 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. e 4-(Oxiran-2-ylmethoxy)-9H-carbazole. f 3,3¢-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g Tsis quav ntsej tej impurity tsawg dua 0.01%.

• Organic impurities, txheej txheem 2

Kev daws A: Acetonitrile thiab trifluoroacetic acid (100: 0.1)

Tshuaj B: Trifluoroacetic acid thiab dej (0.1:100)

Diluent: Acetonitrile, trifluoroacetic acid, thiab dej (22: 0.1: 78)

Mobile theem: Saib Table 2

Rooj 2

Sijhawm (min)	Solution A (%)	Solution B (%)
0	22	78
20	22	78
33	38	62
45	38	62
55	55	45
65	55	45
68	22	78
80	22	78

Kev daws teeb meem tsim nyog: 1.0 mg / mL ntawm USP Carvedilol System Suitability Mixture RS hauv Diluent

Cov qauv tshuaj: 1 mg / mL ntawm Carvedilol hauv Diluent

Chromatographic system

(Saib Chromatography <621>, System Suitability.)

Qauv: LC

Detector: UV 240 nm

Kem: 4.6-mm x 15-cm;5-µm ntim L68

Kem kub: 30 ℃

Tus nqi ntws: 1.4 mL / min

Kev txhaj tshuaj loj: 20 µL

Qhov system haum

Qauv: Kev daws teeb meem tsim nyog

Suitability xav tau

Kev daws teeb meem: NLT 1.8 ntawm carvedilol thiab carvedilol ntsig txog F

Kev tsom xam

Qauv: qauv tov

Xam cov feem pua ntawm txhua qhov impurity hauv feem ntawm Carvedilol noj:

Cov txiaj ntsig = (rU/rT) × 100

rU	=	ncov teb rau txhua impurity nyob rau hauv cov qauv tov
rT	=	sum ntawm tag nrho cov ntsiab lus teb nyob rau hauv cov qauv tov

Kev lees txais: Saib Table 3.

Table 3

Lub npe	kwv tij Khaws cia Sijhawm	Txais Cov txheej txheem, NMT (%)
Carvedilol muaj feem xyuam nrog Aa	0.7 ua	0.1
Carvedilol	1.0	—
Carvedilol muaj feem xyuam nrog Fb	1.2	0.1c
N-Isopropylcarvedilold	1.6	0.1
Carvedilol muaj feem xyuam nrog Ce	1.8	0.02 ib
Carvedilol muaj feem xyuam nrog Bf	2.1	0.1
Biscarbazoleg	3	0.1
Lwm tus neeg impurity	—	0.1
Tag nrho impurities	—	0.5
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9Hcarbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamine) propan-2-ol . b 1-(2-(2-Methoxyphenoxy)ethylamine)-3-(6,7,8,9-tetrahydro-5H-carbazol-4-yloxy)propan-2-ol. c Cov impurity no yog quantitated siv cov txheej txheem raws li Organic impurities, txheej txheem 3: Carvedilol Related Compound F. d 1-(H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]N-isopropylamino]-2-propanol. e 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. f 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g 1,3-Bis-(9H-carbazol-4-yloxy)-2-propanol.

• Organic Impurities, Txheej Txheem 3: Carvedilol Related Compound F (yog muaj)

Tshuaj A: Trifluoroacetic acid thiab dej (0.5:100)

Tshuaj B: Methanol thiab trifluoroacetic acid (100:0.5)

Diluent: Dej thiab acetonitrile (1: 1)

Mobile Theem: Solution A thiab Solution B (65:35)

Kev daws teeb meem tsim nyog: 1.5 mg / mL ntawm USP Carvedilol System Suitability Mixture RS hauv Diluent

Cov qauv tshuaj: 1.5 mg / mL ntawm Carvedilol hauv Diluent npaj raws li hauv qab no.Siv li 1.9 mL ntawm Diluent ib mg ntawm Carvedilol, thiab sonicate luv luv los pab txhawb kev tawg.

Chromatographic system

(Saib Chromatography <621>, System Suitability.)

Qauv: LC

Detector: UV 226 nm

Kem: 4.6-mm × 30-mm;3-µm ntim L7

Kem kub: 40 ℃

Tus nqi ntws: 2 mL / min

Kev txhaj tshuaj loj: 10 µL

Qhov system haum

Qauv: Kev daws teeb meem tsim nyog

Suitability xav tau

Kev daws teeb meem: NLT 2.0 ntawm carvedilol thiab carvedilol ntsig txog F

Kev tsom xam

Qauv: qauv tov

Xam qhov feem pua ntawm carvedilol muaj feem xyuam nrog F hauv feem ntawm cov qauv coj mus kuaj:

Cov txiaj ntsig = (rU/rT) × (1/F) × 100

rU	=	Peak teb ntawm carvedilol muaj feem xyuam nrog F los ntawm cov qauv tshuaj
rT	=	sum ntawm cov lus teb ncov ntawm carvedilol thiab carvedilol muaj feem xyuam nrog F los ntawm cov qauv tshuaj
F	=	txheeb ze teb yam, 1.1

Kev lees txais: NMT 0.1%

TSEEM CEEB

• Poob rau ziab <731>: Qhuav ib qho qauv ntawm 105 ℃ rau 3 h: nws poob NMT 0.5% ntawm nws qhov hnyav.

TSEEM CEEB

• Ntim thiab Cia: Khaws rau hauv cov thawv ntim nruj, thiab khaws cia ntawm chav tsev kub.

• Kev Sau Npe: Yog tias kev sim rau Organic Impurities los ntawm HPLC uas tsis yog Txoj Cai 1 raug siv, ces daim ntawv lo qhia txog qhov kev xeem uas tsab xov xwm ua raws.

• USP Reference Standards <11>

USP Carvedilol RS

USP Carvedilol Related Compound A RS
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamine)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamine) propan-2- ol.
C36H43N3O7 629.74

USP Carvedilol Related Compound B RS
3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
C39H39N3O6 645.74

USP Carvedilol Related Compound C RS
1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
C31H32N2O4 496.60

USP Carvedilol Related Compound D RS
4-(Oxiran-2-ylmethoxy)-9H-carbazole.
C15H13NO2 239.27

USP Carvedilol Related Compound E RS
2- (2-Methoxyphenoxy) ethyl amine.
C9H13NO2 167.21

USP Carvedilol System Suitability Mixture RS
Kev sib xyaw ntawm kwv yees li 0.1% carvedilol muaj feem xyuam nrog F (1-(2-(2-Methoxyphenoxy)ethylamine)-3-(2,3,4,9-tetrahydro-1H-carbazol-5-yloxy)propan-2-ol) nyob rau hauv ib tug matrix ntawm carvedilol tshuaj yeeb tshuaj.