Daclatasvir Dihydrochloride Intermediate CAS 1007882-23-6 Purity > 98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Daclatasvir Dihydrochloride Intermediate (CAS: 1007882-23-6) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, me me thiab ntau ntau muaj.Yuav Daclatasvir Dihydrochloride Intermediates,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Di-tert-Butyl (2S,2'S)-2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-Pyrrolidinecarboxylate) |
| Synonyms | Daclatasvir Intermediate Ⅱ;Dacaltasvir Intermediate 02;Daclatasvir T-Butyl Ester;Bis(2-Methyl-2-Propanyl) (2S,2'S)-2,2'-[4,4'-Biphenyldiylbis(1H-Imidazole-4,2-diyl)]di(1-Pyrrolidinecarboxylate);Di-tert-butyl 2,2′-([1,1′-Biphenyl]-4,4′-diylbis(1H-Imidazole-5,2-diyl))(2S,2'S)-bis(Pyridineidine-1- carboxylate);(2S,2'S)-2,2'-([1,1'-Biphenyl]-4,4'-diyldi-1H-Imidazole-5,2-diyl)bis-1-Pyrrolidinecarboxylic Acid 1,1'-Bis (1,1-Dimethylethyl) Ester;Daclatasvir impurity 4 |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 1007882-23-6 |
| Molecular Formula | C40H51ClN8O6 |
| Molecular Luj | 775.35 g / mol |
| Boiling Point | 890.2 ± 65.0 ℃ ntawm 760 mmHg |
| Qhov ntom | 1.220 ± 0.06g / cm3 |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Qeb | Intermediate ntawm Daclatasvir Dihydrochloride (CAS: 1009119-65-6) |
| Hom | Ruifu Tshuaj |
| Cov khoom | Specifications | Cov txiaj ntsig |
| Qhov tshwm sim | Lub teeb daj rau daj hmoov | Lub teeb daj hmoov |
| Poob rau ziab | <1.00% | 0.65% |
| Qhov siab tshaj plaws ib leeg impurity | <1.00% | 0.45% |
| Tag nrho cov impurities | <2.00% | 1.24% |
| Purity / Analysis Method | > 98.0% (HPLC) | 98.76% |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj thiab ua raws li cov lus qhia tshwj xeeb | |
| Daim ntawv thov | Intermediate ntawm Daclatasvir Dihydrochloride (CAS: 1009119-65-6) | |
Pob:Fluorinated Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav thiab zoo-ventilated warehouse kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Di-tert-Butyl (2S,2'S)-2,2'-(4,4'-Biphenyldiylbis (1H-imidazole-5,2-diyl))di (1-Pyrrolidinecarboxylate) (CAS: 1007882-23-6) yog ib qho nruab nrab ntawm Daclatasvir Dihydrochloride (CAS: 1009119-65-6).
Daclatasvir (Daklinza) tau txais "kev tshuaj xyuas qhov tseem ceeb", ua ke nrog Sorafenib rau kev kho mob ntawm genotype III cov neeg laus cov neeg mob uas muaj kab mob siab C. Daklinza yog thawj cov tshuaj uas tau ua pov thawj tias muaj txiaj ntsig zoo hauv kev kho mob genotype III kab mob siab C. Tsis muaj kev sib koom ua ke nrog interferon lossis ribavirin.Interferon thiab Ribavirin yog ob yam tshuaj pom zoo los ntawm FDA rau kev kho tus kab mob siab C.Kab mob siab C yog kab mob kis uas tuaj yeem ua rau lub siab mob, ua rau lub siab ua haujlwm tsis zoo lossis lub siab tsis ua haujlwm.Feem ntau cov neeg mob uas muaj kab mob siab C tsis muaj tsos mob kom txog thaum lub siab puas tsuaj tshwm sim, uas yuav siv sij hawm ntau xyoo.Thoob plaws ntiaj teb, genotype III kab mob siab C yog qhov thib ob feem ntau genotype ntawm kab mob siab C tom qab genotype 1 kab mob siab C thiab suav tias yog ib qho ntawm cov kab mob refractory genotype tshaj plaws.Daklinza yog pan-genotype NS5A replication complex inhibitor, nrog kev ua tau zoo ntawm inhibition ntawm RNA replication thiab kab mob sib sau ua ke, cov nyhuv antiviral dual.Rau kev tshawb fawb hauv vitro, Daklinza tau pom tias muaj kev tiv thaiv kab mob tiv thaiv kab mob genotype 1 ~ 6 tus kab mob siab C.Daklinza tau nrog kev ceeb toom tias kev sib xyaw ntawm amiodarone, Daklinza thiab Sofosbuvir tuaj yeem ua rau lub plawv dhia hnyav.Daklinza yog ib ntsiav tshuaj ntawm qhov ncauj nrog qhov pom zoo koob tshuaj ntawm 60 mg rau 1 zaug / d, nrog rau Sofosbuvir rau tag nrho 12 lub lis piam.
Lub tuam txhab tshawb fawb thiab kev tsim kho: Bristol-Myers Squibb.
Patent Literature: WO 2008021927A2 (Lub Yim Hli 9, 2007).
Sijhawm ntawm kev lag luam: Lub Xya Hli 24, 2015 teev nyob rau hauv Tebchaws Meskas, lub npe lag luam Daklinza.
Cov Lus Qhia: Siv ua ke nrog Sofosbuvir rau kev kho mob ntawm genotype 3 chronic hepatitis C (HCV) kab mob.
Mechanism of action: HCV nonstructural protein 5A (NS5A) inhibitors.Cov tshuaj tiv thaiv tsis zoo: mob taub hau thiab qaug zog.
Formulation thiab specifications: ntsiav tshuaj, 30 thiab 60mg.
