Tom ntej: Risperidone CAS 106266-06-2 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Risperidone (CAS: 106266-06-2) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Risperidone,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Risperidone |
| Synonyms | 3-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl]ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1. ,2-a]pyrimidin-4-ib;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 106266-06-2 |
| Molecular Formula | C23H27FN4O2 |
| Molecular Luj | 410.49 g / mol |
| Melting Point | 170.0 txog 174.0 ℃ |
| Qhov ntom | 1.38 ± 0.10g / cm3 |
| Hazard Class | 6.1;Tshuaj lom |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Hom | Ruifu Tshuaj |
| Cov khoom | Specifications | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb rau Off-White Powder | Ua raws |
| Kev Taw Qhia A | Infrared Absorption | Ua raws |
| Kev Qhia B | Lub Sijhawm Teev Tseg: Ua raws li cov khoom siv | Ua raws |
| Poob rau ziab | <0.50% | 0.12% |
| Residue ntawm Ignition | <0.10% | 0.07% |
| Hnyav Hlau | <0.001% | <0.001% |
| Related Compounds | ||
| E-Oxim | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Tej yam tsis paub impurity | <0.10% | <0.10% |
| Tag nrho cov impurities | <0.30% | <0.30% |
| Assay | 98.0 ~ 102.0% (Xam rau ntawm Kev Qhuab Qhia) | 100.52% |
| Xaus | Cov khoom tau raug kuaj thiab ua raws li USP 35 Standard | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Risperidone
C23H27FN4O2 410.48
4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7 8,9-tetrahydro-2-methyl-.
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-ib [106266-06-2].
» Risperidone muaj tsis pub tsawg dua 98.0 feem pua thiab tsis ntau tshaj 102.0 feem pua ntawm C23H27FN4O2, xam rau ntawm lub hauv paus qhuav.
Ntim thiab khaws cia - Khaws rau hauv cov thawv kaw kom zoo.Khaws ntawm chav tsev kub.
USP Reference cov qauv <11>-
USP Risperidone RS
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-one 410.48 CAS-106266-06-2
USP Risperidone System Suitability Mixture RS
Muaj cov risperidone thiab txog 0.2% ntawm txhua yam hauv qab no:
Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9- tetrahydro-4H-pyrido[1,2-a] pyrimidin-4-ib.
9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-ib.
6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-ib.
[Ceeb toom-Qhov sib xyaw no muaj risperidone, Z-oxime, 9-hydroxyrisperidone, thiab 6-methylrisperidone.]
Kev txheeb xyuas-
A: Infrared Absorption <197K>.
B: Lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm Assay kev npaj sib raug rau qhov ntawd nyob rau hauv chromatogram ntawm Standard npaj, raws li tau txais hauv Assay.
Poob ntawm ziab <731>- Qhuav hauv lub tshuab nqus tsev ntawm 80 rau 4 teev: nws poob tsis ntau tshaj 0.5% ntawm nws qhov hnyav.
Residue ntawm ignition <281>: tsis ntau tshaj 0.1%, 2.0-g kuaj cov qauv siv.
Cov hlau hnyav, Txoj Kev II <231>: 0.001%.
Related compounds-
Kev daws teeb meem tsis, Kev daws A, Kev daws B, theem txawb, Diluent, Kev daws teeb meem tsim nyog, thiab Chromatographic system-Npaj raws li qhia hauv Kev Tshawb Fawb.
Standard tov-Siv tus txheej txheem npaj, npaj raws li qhia nyob rau hauv Assay.
Test solution-Siv qhov Assay npaj.
Cov txheej txheem-Txhim cov ntim sib npaug (kwv yees li 10 µL) ntawm cov txheej txheem kev daws teeb meem thiab cov tshuaj ntsuam xyuas rau hauv chromatograph, thiab sau cov chromatogram.Txheeb xyuas cov impurities siv cov txheeb ze tuav lub sij hawm muab rau hauv Table 1, thiab ntsuas cov lus teb siab kawg.Xam qhov feem pua ntawm txhua cov risperidone muaj feem xyuam nrog hauv feem ntawm Risperidone coj los ntawm cov mis:
100 (CS / CU) (rU / rS) (1 / F)
nyob rau hauv uas CS thiab CU yog cov concentrations, nyob rau hauv mg ib mL, ntawm risperidone nyob rau hauv tus txheej txheem tov thiab Test tov raws li;rU yog qhov chaw siab tshaj ntawm txhua qhov impurity tau los ntawm Kev Ntsuas Kev Ntsuas;rS yog qhov chaw siab tshaj ntawm risperidone tau los ntawm Standard tov;thiab F yog qhov txheeb ze teb rau txhua qhov impurity txheeb ze rau risperidone.Ntxiv rau qhov tsis pub tshaj qhov txwv hauv Table 1, tsis pub ntau tshaj 0.10% ntawm qhov tsis paub impurity (siv F tus nqi ntawm 1.0) pom thiab tsis pub tshaj 0.30% ntawm tag nrho cov impurities pom.Tsis quav ntsej cov impurity peaks uas tsawg dua 0.05%.
Table 1
Related Compound Relative Retention Time (RRT) Relative Response Factor (F) Limit (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
Cov tshuaj Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2-[4-[(E)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-ib
2 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-ib
3 (9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-ib
4 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-ib
5 (6RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-ib
Assay-
Buffer solution - Dissolve 15.4 g ntawm ammonium acetate hauv 1 L dej.Kho nrog 10% acetic acid rau pH ntawm 6.5, thiab sib tov.
Tshuaj A-Mix 100 mL ntawm Buffer tov nrog 150 mL ntawm methanol nyob rau hauv 1000-mL volumetric hwj, thiab dilute nrog dej rau ntim.
Tshuaj B- Sib tov 100 mL ntawm Buffer tov nrog 850 mL ntawm methanol nyob rau hauv 1000-mL volumetric hwj, thiab dilute nrog dej rau ntim.
Txawb theem-Siv sib txawv sib txawv ntawm cov tshuaj A thiab tshuaj B raws li qhia rau Chromatographic system.Hloov kho yog tias tsim nyog (saib System Suitability hauv Chromatography 621).
Diluent-Mix 100 mL ntawm Buffer tov nrog 900 mL dej thiab 1000 mL ntawm methanol.
System suitability tov- Npaj ib 1 mg ib mL tov ntawm USP Risperidone System Suitability Mixture RS hauv Diluent.
Cov txheej txheem kev npaj-Dissolve ib qho hnyav hnyav ntawm USP Risperidone RS hauv Diluent, thiab dilute quantitatively, thiab stepwise yog tias tsim nyog, nrog Diluent kom tau txais ib qho kev daws teeb meem uas paub txog 1.0 mg ib mL.
Kev tshuaj ntsuam xyuas-Dissolve ib qhov hnyav hnyav npaum li cas ntawm Risperidone hauv Diluent, thiab dilute kom muaj nuj nqis, thiab stepwise yog tias tsim nyog, nrog Diluent kom tau txais cov tshuaj uas muaj cov concentration ntawm 1.0 mg ib mL.
Chromatographic system (saib Chromatography <621>)- Cov kua chromatograph yog nruab nrog 275-nm detector thiab 4.6-mm × 10-cm kem uas muaj 3-µm packing L1.Tus nqi ntws yog li 1.5 mL ib feeb.Lub kem kub yog tswj ntawm 35. Lub chromatograph yog programmed raws li nram no.
Sijhawm (feeb) Tshuaj A (%) Tshuaj B (%) Elution
0–170 30 Ib
1-20 70®5 30®95 linear gradient
20–25 5 95 Ib
25-27 5®70 95®30 linear gradient
27–35 70 30 re-equilbrationInject the System suitability solution.Sau cov lus teb ncov raws li tau hais tseg rau Cov Txheej Txheem, thiab txheeb xyuas cov peaks vim Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, thiab risperidone siv lub sijhawm tuav tus txheeb ze (RRT) los ntawm Table 1;qhov kev daws teeb meem, R, ntawm Z-oxime thiab 9-hydroxyrisperidone tsis tsawg dua 2.8;qhov tailing factor rau risperidone tsis ntau tshaj 1.5;thiab tus txheeb ze tus qauv sib txawv rau kev txhaj tshuaj replicate tsis ntau tshaj 2.0% rau lub ncov risperidone.
Cov txheej txheem - cais cov ntim sib npaug (kwv yees li 10 µL) ntawm Standard npaj thiab Assay npaj rau hauv chromatograph, thiab ntsuas cov lus teb rau lub ncov risperidone.Xam qhov ntau, hauv feem pua ntawm C23H27FN4O2, hauv feem ntawm Risperidone coj los ntawm cov mis:
100 (CS / CU) (rU / rS)
nyob rau hauv uas CS thiab CU yog cov concentrations, nyob rau hauv mg per mL, ntawm risperidone nyob rau hauv Standard npaj thiab Assay npaj, feem;thiab rU thiab rS yog cov lus teb siab kawg uas tau txais los ntawm Assay npaj thiab Standard npaj, feem.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Risk Codes R25 - Toxic yog nqos
R23/24/25 - Toxic los ntawm kev nqus pa, tiv tauj nrog daim tawv nqaij thiab yog tias nqos.
R11 - Cov nplaim hluav taws kub heev
Kev Nyab Xeeb Kev Nyab Xeeb S28 - Tom qab sib cuag nrog daim tawv nqaij, ntxuav tam sim nrog xab npum-suds ntau.
S36 - Hnav khaub ncaws tiv thaiv zoo.
S45 - Thaum muaj xwm txheej lossis yog tias koj tsis xis nyob, nrhiav kev kho mob tam sim ntawd (qhia daim ntawv lo thaum twg los tau.)
S36/37 - Hnav cov khaub ncaws tiv thaiv thiab hnab looj tes tsim nyog.
S16 - Khaws kom deb ntawm qhov chaw hluav taws xob.
UN IDs 3249
WGK Germany 3
RTECS UV1164800
HS Code 2934999099
Hazard Class 6.1(a)
Packing Group II
Risperidone (CAS: 106266-06-2) muaj antagonism cuam tshuam rau 5HT2 receptors thiab D2 receptors.Risperidone yog siv rau mob schizophrenia mob thiab mob ntev.Antipsychotic tshuaj.Risperidone yog siv rau kev kho mob ntawm tus mob thiab mob schizophrenia thiab lwm yam kev puas siab puas ntsws lub xeev pom cov tsos mob zoo (xws li kev hnov lus, kev xav tsis zoo, kev xav tsis meej, kev ua siab phem, kev xav tsis thoob) thiab cov tsos mob tseem ceeb (xws li tsis teb, kev xav apathy thiab kev tsis sib haum xeeb, ntawm ob peb tug. lus).Tsis tas li ntawd nws tuaj yeem txo cov tsos mob cuam tshuam nrog schizophrenia (xws li: kev nyuaj siab, kev ua txhaum, kev ntxhov siab).Rau cov neeg mob uas Risperidone tau txais txiaj ntsig zoo rau kev kho mob hnyav, nyob rau theem kev saib xyuas ntawm kev kho mob, Risperidone tuaj yeem txuas ntxiv mus ua nws qhov kev kho mob.Risperidone, yog li ntawd, muaj kev kho mob rau ob qho tib si zoo thiab tsis zoo cov tsos mob ntawm tus mob schizophrenia thiab ua rau muaj kev phiv tsawg dua tshwj xeeb tshaj yog cov tsos mob extrapyramidal piv nrog cov feem ntau siv cov ntshiab D2 antagonist antipsychotics.Nws kuj tseem muaj peev xwm tswj hwm kev tshem tawm cawv thiab kev quav yeeb quav tshuaj.
