4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid CAS 123654-26-2 Prucalopride Succinate Intermediate Purity ≥98.0% (HPLC)

Lus piav qhia luv luv:

4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid

CAS: 123654-26-2 Nr

Purity: ≥98.0% (HPLC)

Cov tsos mob: Tawm-dawb mus rau lub teeb-liab khoom

Intermediate ntawm Prucalopride Succinate (CAS: 179474-85-2)

Hu rau: Dr. Alvin Huang

Txawb/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Shanghai Ruifu Chemical yog cov chaw tsim khoom ntawm 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Prucalopride Succinate Intermediates,Please contact: alvin@ruifuchem.com

Prucalopride Succinate Intermediates:

Chemical Properties:

Tshuaj npe 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid
Synonyms 4-Amino-5-Chlorocoumaran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydrobenzo[b]furan-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-1-Benzofuran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-7-Benzofurancarboxylic Acid;Prucalopride impurity A;Prucalopride Succinate Impurity-2
Tshuag xwm txheej Hauv Tshuag, Kev Lag Luam Ntau Lawm
CAS Nr 123654-26-2
Molecular Formula C9H8 NPO 3
Molecular Luj 213.62 g / mol
Melting Point 242 ℃ (txog.)
Boiling Point 406.5 ± 45.0 ℃
Qhov ntom 1.566 ib
COA & MSDS Muaj
Keeb kwm Shanghai, Suav
Qeb Intermediate ntawm Prucalopride Succinate (CAS: 179474-85-2)
Hom Ruifu Tshuaj

Specifications:

Cov khoom Kev soj ntsuam Standards Cov txiaj ntsig
Qhov tshwm sim Tawm-dawb mus rau lub teeb-liab khoom Lub teeb-liab Khoom
Dej los ntawm Karl Fischer ≤ 1.00% 0.35%
Residue ntawm Ignition <0.20% 0.08%
Heavy Metals (Pb) ≤ 20ppm <10ppm
Ib leeg Impurity ≤ 1.00% Ua raws
Tag nrho cov impurities ≤ 2.00% Ua raws
Purity / Analysis Method ≥98.0% (HPLC) 99.6%
Infrared Spectrum Raws li tus qauv Ua raws
1 H NMR Spectrum Raws li tus qauv Ua raws
Xaus Cov khoom tau raug kuaj & ua raws li cov lus qhia tshwj xeeb

Pob / Cia /Shipping:

Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.

123654-26-2 - Test Method:

Cov khoom no yog 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid, cov ntsiab lus ntawm C12H12ClNO4 yuav tsum tsis pub tsawg tshaj 98.0%, xam raws li lub hauv paus anhydrous.
[Properties] Cov khoom no yog tawm-dawb mus rau lub teeb-liab khoom.
[Kuaj]
Noj cov khoom no (kwv yees li 0.5g) dej, ntxiv hnyav (methanol: N, N-dimethylformamide = 50:50), thiab yaj nws raws li kev txiav txim siab dej (Appendix Ⅷ M, thawj txoj kev A).Siv Fisher's test drops los txiav txim kom txog thaum cov kev daws teeb meem hloov ntawm lub teeb daj mus rau xim liab-xim av qhia txog qhov kawg, thiab ua lwm qhov kev sim dawb.Muab xam raws li cov qauv hauv qab no: cov ntsiab lus dej yuav tsum tsis pub tshaj 1.00%.
Cov dej noo (%) = (AB) F/W × 100%
Qhov twg, A yog qhov ntim ntawm Fisher's kua noj los ntawm cov khoom kuaj (ml);
B yog qhov ntim ntawm Fisher's test kua siv los ntawm qhov chaw seem, ml;
F yog qhov hnyav ntawm Fisher's test tov sib npaug rau dej ib 1ml, mg;
W yog qhov hnyav ntawm cov khoom kuaj, mg
Muaj feem xyuam
Raws li cov txheej txheem hauv qab "Cov ntsiab lus ntsuas", yog tias muaj cov impurity peaks nyob rau hauv chromatogram ntawm cov tshuaj ntsuam xyuas, lub ncov cheeb tsam ntawm ib tug impurity yuav tsum tsis txhob ntau tshaj 10 zaug (1.0%) ntawm lub ntsiab ncov cheeb tsam ntawm kev tswj. kev daws, thiab qhov sib npaug ntawm thaj chaw ncov ntawm tag nrho cov impurities yuav tsum tsis txhob ntau tshaj 20 npaug (2.0%) ntawm lub ntsiab ncov cheeb tsam ntawm kev tswj kev daws.
[Kev Txiav Txim Cov Ntsiab Lus] Raws li kev ua haujlwm siab ua kua chromatography (Appendix VI D).
Octadecylsilane bonded silica gel tau siv los ua tus muab tub lim rau chromatographic tej yam kev mob thiab kev ntsuas qhov tsim nyog.Phosphate buffer tov (1.36g poov tshuaj dihydrogen phosphate, yaj ultrasonic nyob rau hauv 1L dej, phosphoric acid hloov mus rau PH 3.0) yog siv raws li mobile theem A. Acetonitrile yog mobile theem B, thiab gradient elution yog ua raws li cov lus hauv qab no:
Lub sij hawm (min) Txawb theem A mobile theem B
080 20
1580 20 ib
30 50 50
45 50 50
Qhov ntsuas wavelength yog 254 nm.Tus nqi ntws yog 1.0 ml / min.Tus naj npawb ntawm cov ntawv theoretical tsis tsawg dua 2000 raws li lub ncov ntawm 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid
Lub ncov ntawm furanoformic acid tsis tsawg dua 2000.
Txoj kev txiav txim:
Noj 10mg ntawm cov khoom kuaj, ntsuas kom raug, muab tso rau hauv A 10ml lub raj mis, yaj nws ultrasonic nrog mobile theem A-mobile theem B (70:30) raws li hnyav, dilute nws mus rau lub teev, co zoo, thiab npaj ib tug kev daws teeb meem nrog ib qho concentration ntawm 1mg / ml.20 l ntawm precision raug txhaj rau hauv cov kua chromatograph, thiab cov chromatogram raug kaw.Lub ntsiab ncov purity tsis tsawg tshaj li 98.0% raws li lub ncov cheeb tsam normalization txoj kev
Kem: Dionex Acclaim C18, 4.6 * 250mm, 5um
Kem kub: 40 ℃
Flow tus nqi: 1.0ml / min
Ntsuas wavelength: 254nm
Qauv loj: 10μL

Qhov zoo:

Muaj peev xwm txaus: Muaj cov chaw txaus thiab cov kws tshaj lij

Kev Pabcuam Kev Ua Haujlwm: Ib qho kev pabcuam kev yuav khoom

Pob OEM: Kev cai pob thiab daim ntawv lo muaj

Kev xa khoom sai: Yog tias nyob hauv Tshuag, peb hnub xa khoom lav

Stable Supply: Khaws cov khoom tsim nyog

Kev them nyiaj yug Technical: Technology tov muaj

Kev Pabcuam Synthesis: Ntau yam ntawm grams mus rau kilos

High Quality: Tsim kom muaj kev ruaj ntseg zoo

FAQ:

Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.

Daim ntawv thov:

4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2), tuaj yeem siv los ua qhov nruab nrab rau kev sib txuas ntawm Prucalopride Succinate (CAS: 179474-85-2), ib qho kev xaiv 5-HT4 receptor agonist siv zoo rau kev cem quav ntev.Prucalopride Succinate, thawj-hauv-chav kawm dihydrobenzofurancarboxamide, yog ib qho kev xaiv serotonin (5- HT4) receptor agonist.Cov tshuaj, ua lag luam nyob rau hauv lub npe hom Resolor®, muaj cov kev ua haujlwm enterokinetic thiab tau tsim los ntawm Belgian-based kws tshuaj Movetis.Prucalopride hloov colonic motility qauv ntawm serotonin 5-HT4 receptor stimulation, ua rau lub hauv paus propulsive quab yuam rau defecation.

Sau koj cov lus ntawm no thiab xa tuaj rau peb