2-Cyanophenylboronic Acid 1,3-Propanediol Ester CAS 172732-52-4 Perampanel Intermediate Purity > 99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm 2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) nrog cov khoom zoo, nruab nrab ntawm Perampanel (CAS: 380917-97-5).Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Perampanel intermediates, Please contact: alvin@ruifuchem.com
| Tshuaj npe | 2-Cyanophenylboronic Acid 1,3-Propanediol Ester |
| Synonyms | 2-Cyanobenzeneboronic Acid 1,3-Propanediol Ester;2-(1,3,2-Dioxaborinan-2-yl) benzonitrile Cov |
| CAS Nr | 172732-52-4 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C10H10BNO2 |
| Molecular Luj | 187.01 Nws |
| Melting Point | 46.0 ~ 51.0 ℃ (lit.) |
| Qhov ntom | 1.13 ± 0.10g / cm3 |
| Solubility | Soluble hauv Methanol |
| Kev ruaj ntseg | Hygroscopic |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau lub teeb daj hmoov rau Crystal |
| Purity / Analysis Method | > 99.0% (HPLC) |
| Poob rau ziab | <0.50% |
| Residue ntawm Ignition | <0.20% |
| Ib leeg Impurity | <0.50% |
| Tag nrho cov impurities | <1.00% |
| Heavy Metals (raws li Pb) | <20 ppm |
| Test Standard | Enterprise Standard |
| Kev siv | Intermediate of Perampanel (CAS: 380917-97-5) |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo.
Hazard Symbols Xi - Irritant
Risk Codes
R20/21/22 - Ua phem los ntawm kev nqus pa, tiv tauj nrog daim tawv nqaij thiab yog tias nqos.
R36/37/38 - Kab mob rau qhov muag, ua pa thiab tawv nqaij.
Kev nyab xeeb piav qhia
S26 - Nyob rau hauv rooj plaub ntawm qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
S36/37/39 - Hnav cov khaub ncaws tiv thaiv, hnab looj tes thiab tiv thaiv qhov muag / ntsej muag.
UN IDs 3439
WGK Germany 3
TSCA No
Hazard Note Irritant
2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) yog siv rau hauv kev sib txuas ntawm Perampanel (CAS: 380917-97-5), AMPA receptor antagonist.Perampanel (daim ntawv tso cai nyob rau hauv 2012) yog ib tiam thib peb AED paub nrog lub npe tswv ntawm Fycompa® (Eisai, Hatfield) hauv UK thiab Banzel® (Eisai, Hatfield) hauv Tebchaws Meskas.Thaum Lub Kaum Hli 2012, US FDA tau pom zoo perampanel rau kev kho mob ntawm qee qhov pib qaug dab peg hauv cov neeg mob vwm uas muaj hnub nyoog tsawg kawg 12 xyoos.Perampanel yog thawj tus AMPA receptor antagonist kom tau txais FDA pom zoo raws li AED.AMPA glutamate receptors feem ntau pom ntawm postsynaptic neurons hauv lub hlwb.Raws li kev xaiv, tsis muaj kev sib tw antagonist ntawm AMPA, parampanel tiv thaiv ion channel qhib thiab txo qis kev nthuav tawm ntawm qhov ua tau zoo.Perampanel tau pom zoo los ntawm European EMA thiab US FDA thaum Lub Xya Hli thiab Lub Kaum Hli 2012 raws li, nws yog siv rau kev kho mob ntxiv rau cov neeg mob uas muaj kev qaug dab peg ntau dua 12 xyoos nrog lossis tsis muaj kev qaug dab peg.Thaum Lub Rau Hli 22, 2015, Eisai tshaj tawm tias US FDA tau pom zoo nthuav tawm qhov qhia txog Pirenparanide hydrate (Fycompa) ua ib qho kev kho mob ntxiv rau thawj cov tonic-clonic qaug dab peg hauv cov neeg mob ntshav qab zib hnub nyoog 12 thiab siab dua.
