1-(3-Methoxypropyl)-4-Piperidinamine CAS 179474-79-4 Prucalopride Succinate Intermediate Purity > 98.0% (GC)

Cov khoom no yog 1-(3-Methoxypropyl)-4-Piperidinamine.Muaj C9H20N2O yuav tsum tsis pub tsawg dua 98.0%, suav nrog lub hauv paus anhydrous.
[Properties: Cov khoom no tsis muaj xim rau cov kua daj daj.
Siv cov dej tsim nyog ntawm cov khoom no, ntxiv cov kuab tshuaj (methanol), yaj nws, txiav txim siab raws li txoj kev txiav txim siab dej (Appendix Ⅷ M, thawj txoj kev A), siv Fisher's test drops los txiav txim kom txog thaum cov tshuaj hloov los ntawm lub teeb daj. mus rau liab xim av qhia qhov kawg point, thiab ua lwm yam dawb paug xeem.Muab xam raws li cov qauv hauv qab no: cov ntsiab lus dej yuav tsum tsis pub tshaj 1.0%.
Cov dej noo (%) = (AB) F/W × 100%
Qhov twg, A yog qhov ntim ntawm Fisher's kua noj los ntawm cov khoom kuaj (ml);
B yog qhov ntim ntawm Fisher's test kua siv los ntawm qhov chaw seem, ml;
F yog qhov hnyav ntawm Fisher's test tov sib npaug rau dej ib 1ml, mg;
W yog qhov hnyav ntawm cov khoom kuaj, mg
Ib leeg impurity
Raws li cov txheej txheem tshawb nrhiav thiab cov txheej txheem hauv qab [kev txiav txim siab cov ntsiab lus], chromatogram tau sau tseg thiab lub sijhawm khaws cia los ntawm qhov siab tshaj plaws yog 3 zaug.Yog hais tias muaj impurity ncov nyob rau hauv cov kev daws teeb meem, ib qho impurity yuav tsum tsis pub ntau tshaj 0.5% thiab tag nrho cov impurities yuav tsum tsis txhob ntau tshaj 2.0% raws li lub cheeb tsam normalization txoj kev.
[Kev Txiav Txim Cov Ntsiab Lus] Raws li kev txiav txim siab ntawm cov khoom hnyav (Appendix Ⅷ P)
(6%) cyanopropyl phenyl - (94%) dimethylpolysiloxane (los yog zoo sib xws polarity) raws li cov kua capillary kem;
Cov txheej txheem ua kom sov txoj kev ntawm capillary kem headspace sampling system nrog roj chromatographic mob tau siv.Thawj qhov ntsuas kub yog 100 ℃ rau 5 feeb, thiab qhov kub tau nce ntawm 15 ℃ ib feeb rau 250 ℃ rau 4min.Inlet kub yog 250 ℃, thiab ntsuas kub yog 280 ℃.Tus nqi ntws yog 4ml / min.Qhov sib piv ntawm shunt yog 8: 1.
Txog 0.6g ntawm cov khoom no tau muab coj los ntsuas, ntsuas kom raug, muab tso rau hauv lub raj mis 10ml, yaj nrog methanol thiab diluted rau qhov ntsuas, raws li cov khoom siv tshuaj ntsuam xyuas.Cov qauv tshuaj tau txhaj nrog 1μl rau tsawg kawg ob zaug sib law liag, feem.Qhov chaw siab tshaj ntawm lub ncov yuav tsum tau ntsuas.Lub ntsiab ncov purity tsis tsawg tshaj li 98.0% raws li lub ncov cheeb tsam normalization txoj kev.