Gefitinib Intermediate CAS 184475-71-6 Purity > 99.0% (HPLC)

Lus piav qhia luv luv:

4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol

Synonyms: FAAH-IN-2;O-Desmorpholinopropyl Gefitinib

CAS: 184475-71-6 Nr

Purity:> 99.0% (HPLC)

Qhov tshwm sim: Yuav luag Dawb rau Grey Hmoov

Intermediate of Gefitinib (CAS: 184475-35-2)

Hu rau: Dr. Alvin Huang

Txawb/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Product Detail

Yam khoom

Khoom cim npe

Nqe lus piav qhia:

Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm 4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol (CAS: 184475-71-6) nrog cov khoom zoo, nruab nrab ntawm Gefitinib (CAS) : 184475-35-2).Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, me me thiab ntau ntau muaj.Yuav Gefitinib intermediates,Please contact: alvin@ruifuchem.com

Gefitinib Intermediates:

Chemical Properties:

Tshuaj npe 4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol
Synonyms FAAH-IN-2;O-Desmorpholinopropyl Gefitinib;4-(3-Chloro-4-Fluoroanilino)-6-Hydroxy-7-Methoxyquinazoline;Gefitinib impurity;Gefitinib Intermediate VII
CAS Nr 184475-71-6
Tshuag xwm txheej Hauv Tshuag
Molecular Formula C15H11ClFN3O2
Molecular Luj 319.72 ib
Melting Point ≥ 260 ℃ (txog.)
Qhov ntom 1.489 ± 0.06 g / cm3
COA & MSDS Muaj
Keeb kwm Shanghai, Suav
Hom Ruifu Tshuaj

Specifications:

Yam khoom Specifications
Qhov tshwm sim Yuav luag Dawb rau Grey Hmoov
Melting Point > 260.0 ℃
Poob rau ziab <1.00%
Yam khoom muaj feem
Ib leeg Impurity <1.00%
Tag nrho cov impurities <1.00%
Purity / Analysis Method > 99.0% (HPLC)
Test Standard Enterprise Standard
Kev siv Intermediate of Gefitinib (CAS: 184475-35-2)

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo.

Qhov zoo:

1

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184475-71-6 - Daim ntawv thov:

4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol (CAS: 184475-71-6) yog ib qho nruab nrab ntawm Gefitinib (CAS: 184475-35-2), metabolite ntawm Gefitinib.Gefitinib yog ib qho tshuaj antineoplastic lub hom phiaj kho mob uas muaj qhov tshwj xeeb uas tau tsim los ntawm lub tuam txhab tshuaj British AstraZeneca;nws yog thawj cov tshuaj tiv thaiv molecular los siv rau hauv kev kho mob qog noj ntshav uas tsis yog me me.Epidermal kev loj hlob yam tseem ceeb (EGF) yog ib hom polypeptide nrog cov txheeb ze molecular loj ntawm 6.45x103, thiab lawv tuaj yeem khi nrog epidermal growth factor receptors (EGFR) ntawm lub hom phiaj cell membrane nto los ua rau muaj kev cuam tshuam txog kev loj hlob.EGFR yog ib hom tyrosine kinase (TK) hom receptor, yog li thaum khi nrog EGF, nws yuav txhawb nqa TK kev ua haujlwm hauv receptor.Qhov no yuav ua rau tyrosine residue nyob rau hauv lub receptor mus rau autophosphorylate thiab xa cov kev sib faib tsis tu ncua mus rau hauv lub cell, ua rau cell proliferation thiab sib txawv.Gefitinib thaiv cov teeb liab hloov txoj hauv kev ntawm lub xov tooj ntawm tes EGFR los tiv thaiv qog kev loj hlob, metastasis, thiab kev loj hlob hauv cov hlab ntsha, thiab nws tuaj yeem ua rau qog cell apoptosis.

Sau koj cov lus ntawm no thiab xa tuaj rau peb