Vardenafil Intermediate CAS 224789-21-3 Purity > 99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one (CAS: 224789-21-3) nrog cov khoom zoo, nruab nrab ntawm Vardenafil.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Vardenafil Intermediates,Please contact: alvin@ruifuchem.com
| Tshuaj npe | 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-ib |
| Synonyms | Vardenafil Dessulfonyl impurity;2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazo[5,1-F][1,2,4]triazin-4-one;Vardenafil Propyl Imidazotriazinone impurity;Vardenafil Related Compound 1 |
| Tshuag xwm txheej | Hauv Tshuag, Muaj Peev Xwm Ntau Lawm 2 Tons ib hlis |
| CAS Nr | 224789-21-3 |
| Molecular Formula | C17H20N4O2 |
| Molecular Luj | 312.37 g / mol |
| Melting Point | 142.0 ~ 148.0 ℃ |
| Qhov ntom | 1.26 ± 0.10g / cm3 |
| Kev Cia Lub Sij Hawm Ntev | Qhov chaw txias & qhuav (2 ~ 8 ℃) |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Hom | Ruifu Tshuaj |
| Cov khoom | Specifications | Cov txiaj ntsig |
| Qhov tshwm sim | Off-White to Pale Yellow Powder | Off-White hmoov |
| Melting Point | 142.0 ~ 148.0 ℃ | 146.0 ~ 147.0 ℃ |
| Poob rau ziab | ≤1.00% (102 ℃, 3h) | 0.23% |
| Heavy Metals (Pb) | ≤ 20ppm | <20 ppm |
| Purity / Analysis Method | > 99.0% (HPLC) | 99.79% |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj thiab ua raws li cov lus qhia tshwj xeeb | |
| Daim ntawv thov | Qhov nruab nrab ntawm Vardenafil / Vardenafil Hydrochloride | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm tshav ntuj thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
1. Cov tsos mob: Muab cov qauv tso rau ntawm daim ntawv dawb thiab saib cov tsos, tawm-dawb mus rau daj ntseg daj hmoov.
2. Kev tshuaj xyuas:
2.1 Melting Point kev txiav txim raws li txoj cai (Suav Pharmacopoeia 2010 Edition II Appendix ⅥC) Melting point yog 142.0 ~ 148.0 ℃.
2.2 Loss on Drying: Kev txiav txim raws li txoj cai (Appendix ⅧL, Part II, 2010 Edition of Chinese Pharmacopoeia).Precision hnyav qhov tsim nyog ntawm cov khoom no, qhuav ntawm 102 ℃ rau 3 teev, qhov hnyav yuav tsum tsis pub tshaj 1.00%.
2.3 Heavy Metals: Kev txiav txim siab raws li txoj cai (Tib neeg lub koom pheej ntawm Tuam Tshoj Pharmacopoeia 2010 Edition, Tshooj II Daim Ntawv Ntxiv ⅧH) Kev txiav txim siab los ntawm txoj kev thib ob.
Precision hnyav 1.0g ntawm cov khoom kuaj, maj mam hlawv kom txog thaum carbonized tag, txias, ntxiv 0.5-1.0ml sulfuric acid, ua kom nws ntub, kub kub kom txog thaum lub sulfuric acid tag, ntxiv 0.5ml nitric acid, chav qhuav, kom txog rau thaum lub sulfuric acid yog tas. nitrogen oxide vapor yog tas, txias, kub ntawm 500-600 ℃ kom carbonized tag, txias, ntxiv 2ml hydrochloric acid, Tom qab ziab hauv dej da dej, ntxiv 15ml dej, tso cov tshuaj ammonia mus rau qhov nruab nrab ntawm phenolphthalein qhia. tov, ntxiv 2ml acetate buffer (ph3.5), thiab me ntsis tshav kub yaj, txav mus rau lub Nachner colorimetric raj, thiab dilute nws mus rau hauv 25ml nrog dej.Siv lwm cov tshuaj reagent rau kev npaj cov tshuaj ntsuam xyuas, thiab muab tso rau hauv ib lub tais porcelain, ntxiv 2ml acetate buffer (PH3.5) thiab 15ml dej kom sov me ntsis Tom qab dissolution, txav lub Nath colorimetric raj, ntxiv ib tug npaum li cas ntawm cov qauv txhuas tov, thiab tom qab ntawd dilute nrog dej rau 25 ml.Kev sim Colorimetric yog ua los ntawm kev sim tshuaj thiab cov qauv kev daws teeb meem kom tau txais.Standard tov npaj raws li (Tib neeg lub koom pheej ntawm Tuam Tshoj Pharmacopoeia 2010 tsab II Appendix Ⅷ Heavy hlau xeem txoj kev) thawj txoj kev.Cov hlau hnyav yuav tsum tsis pub tshaj 20 feem ntawm ib lab.
3. Purity: Raws li kev ua haujlwm siab ua kua chromatography, txiav txim siab raws li txoj cai (Suav Pharmacopoeia 2010 tsab II Appendix VD).
Chromatographic tej yam kev mob:
Kem: C18, 200mm × 4.6mm, 5μm;
Mobile theem: Phosphate buffer (hnyav 2.72g potassium dihydrogen phosphate, ntxiv dej kom yaj thiab dilute rau 1000ml, kho pH = 3.5): acetonitrile: = 35:65;
Ntsuas wavelength: 254nm;
Flow tus nqi: 1.0ml / min
Kev txiav txim siab txoj kev: Siv li 30mg ntawm cov khoom no, ntsuas kom raug, dilute nws nrog mobile theem kom cov concentration ntawm txog 0.3mg / ml, noj 20μl rau hauv cov kua chromatograph, sau cov chromatogram.Raws li qhov chaw normalization txoj kev, purity tsis tsawg tshaj li 99.0%.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one (CAS: 224789-21-3) yog ib qho nruab nrab ntawm Vardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).Vardenafil yog PDE5 inhibitor tshiab tau tsim tawm rau kev kho qhov ncauj ntawm cov txiv neej erectile kawg thiab nws muaj cov qauv zoo sib xws nrog sildenafil (Viagra), uas yog thawj PDE5 inhibitor qhia hauv xyoo 1998 rau qhov kev qhia no.
Vardenafil yog tus neeg sawv cev thib ob uas yuav tsum tau ua lag luam thiab muaj qhov zoo dua tias nws lub sijhawm pib tsis raug txo los ntawm kev noj cov tshuaj ntawm lub plab tas.Nws yog 30 npaug ntau lub zog ua tus inhibitor ntawm PDE5 (txhais tau tias IC50, 3.9 nM) dua li sildenafil thiab 10 npaug ntau dua li tadalafil, nrog rau kev xaiv ntau dua (> 1,000 zaug) rau tib neeg PDE5 dua li tib neeg PDE2, PDE3, thiab PDE4 thiab nruab nrab xaiv (> 80 zaug) rau PDE1.PDE inhibitory selectivity thiab ob qho tib si hauv vitro thiab hauv vivo potency ntawm PDE5 inhibitor vardenafil tshiab.Vardenafil tshwj xeeb inhibited hydrolysis ntawm cGMP los ntawm PDE5, nrog IC50 ntawm 0.7 nM (sildenafil 6.6 nM).IC50 ntawm vardenafil rau PDE1 yog 180 nM, rau PDE6 11 nM, thiab rau PDE2, PDE3 thiab PDE4 ntau tshaj 1,000 nM.
