Lapatinib Base CAS 231277-92-2 Purity ≥99.0% (HPLC)

Lus piav qhia luv luv:

Lub npe tshuaj:Lapatinib Base

CAS: 231277-92-2 Nr

Purity: ≥99.5% (HPLC)

Yuav luag dawb los yog lub teeb daj crystalline hmoov

Hu rau: Dr. Alvin Huang

Txawb/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Yam khoom

Khoom cim npe

Lapatinib Intermediates:

Lapatinib Base	CAS: 231277-92-2 Nr
Lapatinib Ditosylate Monohydrate	CAS Nr .: 388082-78-8
Sodium Methanesulfinate	CAS 20277-69-4 Nr
3-Chloro-4-(3-Fluorobenzyloxy) aniline	CAS Nr .: 202197-26-0
2-Aminoethyl Methyl Sulfone Hydrochloride	CAS Nr .: 104458-24-4
4-Chloro-6-Iodoquinazoline	CAS Nr .: 98556-31-1
6-Iodo-4-Hydroxyquinazoline	CAS Nr .: 16064-08-7
5-Formyl-2-Furanboronic Acid	CAS Nr .: 27329-70-0
5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde	CAS Nr .: 231278-84-5

Chemical Properties:

Tshuaj npe	Lapatinib Base
Synonyms	Lapatinib;N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[(2-(methylsulfonyl)ethyl]amino]methyl]furan-2-yl]quinazolin-4-amine N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
CAS Nr	231277-92-2
Tshuag xwm txheej	Hauv Tshuag
Molecular Formula	C29H26ClFN4O4S
Molecular Luj	581.06 ib
Melting Point	141.0 ~ 149.0 ℃
Qhov ntom	1.381 ± 0.06 g / cm3
COA & MSDS	Muaj
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Yuav luag dawb los yog lub teeb daj crystalline hmoov
Kev txheeb xyuas	IR;HPLC
Purity / Analysis Method	≥99.0% (HPLC)
Melting Point	141.0 ~ 149.0 ℃
Poob rau ziab	≤0.50%
Residue ntawm Ignition	≤0.10%
Heavy Metals (raws li Pb)	≤ 20ppm
Organic Volatile Impurities	Ua raws li qhov yuav tsum tau ua
Yam khoom muaj feem
Ib leeg Impurity	≤ 0.30%
Tag nrho cov impurities	≤ 1.00%
Test Standard	Enterprise Standard
Txee lub neej	2 Xyoo Thaum Yuav Tsum Tau Zoo
Kev siv	API, Kev Kho Hniav Qhov ncauj rau Mob Cancer

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo

Qhov zoo:

FAQ:

231277-92-2 - Daim ntawv thov:

API CAS: 231277-92-2 Nr.yog ib hom tshuaj kho mob cancer ntawm lub mis, yog tyrosine kinase inhibitor, tuaj yeem cuam tshuam cov tib neeg epidermal kev loj hlob zoo tshaj plaws receptor -1 (ErbB1) thiab tib neeg epidermal growth factor receptor (ErbB2) tyrosine kinase kev ua ntawm -2.Nws yog qhov tshwj xeeb uas nws tuaj yeem ua lub luag haujlwm hauv ntau txoj hauv kev, kom cov qog nqaij hlav cancer mis tsis tuaj yeem tau txais cov teeb liab uas xav tau rau kev loj hlob.Cov txheej txheem ntawm kev ua haujlwm yog txhawm rau tiv thaiv cov kab mob intracellular EGFR (ErbB-1) thiab HER2 (ErbB-2) ATP qhov chaw los tiv thaiv phosphorylation thiab ua kom cov qog hlwb, thiab txhawm rau tiv thaiv kev txo qis ntawm kev taw qhia los ntawm EGFR (ErbB-1) thiab HER2 (ErbB-1) homogeneous thiab heterogeneous ob aggregate.Kev sib xyaw ua ke ntawm (CAS: 231277-92-2) nrog Capecitabine yog siv los kho cov neeg mob uas muaj mob qog noj ntshav siab lossis mob qog noj ntshav nrog ntau dhau ntawm tib neeg epidermal receptor2, twb tau kho nrog anthracyclines, paclitaxel, thiab trastuzumab.Kev sim tshuaj ntsuam xyuas tau pom tias nws kuj tseem kho tau zoo HER2-type cancer cov neeg mob nrog Herceptin tsis kam.

231277-92-2 - Cov lus qhia:

Lapatinib ua ke nrog Capecitabine yog tsim rau kev kho mob ntawm cov neeg mob qog noj ntshav siab lossis mob qog noj ntshav nrog HER2 (ErbB-2 overexpression) thiab kev kho mob yav dhau los suav nrog anthracyclines, paclitaxel thiab trastuzumab.

231277-92-2 - Kev Sib Tham Tshuaj:

In vitro Lapatinib ntsiav tshuaj tuaj yeem cuam tshuam CYP3A4 thiab CYP2C8 ntawm kev kho mob ntau, thiab feem ntau metabolized los ntawm CYP3A4.Cov tshuaj uas inhibit qhov kev ua enzyme no tuaj yeem ua rau kom cov ntshav concentration ntawm Lapatinib nce.Ketoconazole, 0.2g txhua zaus, 2 zaug / d, tuaj yeem nce AUC ntawm Lapatinib los ntawm 3 ~ 7 zaug thiab ncua lub neej ib nrab los ntawm 1.7 zaug tom qab 7 hnub.Cov neeg ua haujlwm noj qab haus huv tau noj CYP3A4 inducer hauv qhov ncauj, 100 mg txhua zaus, ob zaug ib hnub, thiab hloov mus rau 200mg txhua zaus tom qab 3 hnub, sib koom 17 hnub ob zaug hauv ib hnub.AUC ntawm Lapatinib poob los ntawm 72%.Lapatinib yog ib qho chaw thauj khoom rau P-glycoprotein, thiab cov tshuaj uas inhibit glycoprotein tuaj yeem ua rau cov ntshav concentration ntawm cov tshuaj.

Cov Tshuaj Tshiab rau Kev Kho Mob Mob Cancer:

Lapatinib yog ib yam tshuaj tshiab rau kev kho mob cancer mis tsim los ntawm GlaxoSmithKline, UK.Nws yog ib qho tyrosine kinase inhibitor uas tuaj yeem cuam tshuam tib neeg epidermal kev loj hlob zoo tshaj plaws receptor -1 (ErbB1) thiab tib neeg epidermal kev loj hlob receptor -2 (ErbB2) tyrosine kinase kev ua haujlwm.Nws yog qhov tshwj xeeb uas nws tuaj yeem ua haujlwm hauv ntau txoj hauv kev kom cov qog nqaij hlav cancer mis tsis tuaj yeem tau txais cov cim xav tau rau kev loj hlob.Cov txheej txheem ntawm kev ua haujlwm yog txhawm rau tiv thaiv ATP qhov chaw ntawm EGFR (ErbB-1) thiab HER2 (ErbB-2) hauv cov hlwb kom tiv thaiv phosphorylation thiab ua kom cov qog hlwb, thiab thaiv cov kev cai qis los ntawm homogenous thiab heterogeneous dimers ntawm EGFR (ErbB. -1) thiab HER2 (ErbB-1).Molecular targeted therapy rau mob qog noj ntshav yog hais txog kev kho mob ntawm oncogenes thiab lwm yam kev qhia cov khoom muaj feem xyuam rau qhov tshwm sim thiab kev loj hlob ntawm mob qog noj ntshav mis.Molecular tsom cov tshuaj inhibit lossis tua cov qog hlwb los ntawm kev thaiv cov teeb liab hloov hauv cov qog hlwb lossis cov hlwb muaj feem xyuam los tswj cov kev hloov pauv hauv cov noob ntawm tes.Thaum Lub Peb Hlis 14, 2007, Asmeskas kev tswj hwm zaub mov thiab tshuaj tau pom zoo ua ke ntawm lapatinib thiab xeloda (capecitabine) rau kev kho mob ntawm cov neeg mob qog noj ntshav siab lossis metastatic mob qog noj ntshav overexpressed los ntawm tib neeg epidermal factor receptor 2 (ErbB2) thiab kho nrog anthracyclines, paclitaxel thiab trastuzumab. .Kev sim tshuaj ntsuam xyuas pom tau tias cov khoom no kuj muaj cov txiaj ntsig zoo rau cov neeg mob qog noj ntshav HER2 uas tau tsim cov tshuaj tiv thaiv rau Roche's Herceptin (Herceptin).lapatinib yog ib hom tshuaj tiv thaiv kab mob tshiab.Nws tuaj yeem ua rau Nws-1 thiab Nws-2 lub hom phiaj tib lub sijhawm.Cov nyhuv lom ntawm hom kev ua no ntawm kev loj hlob thiab kev loj hlob ntawm cov qog hlwb yog ntau dua li ntawm ib lub hom phiaj xwb.Cov tshuaj tiv thaiv kab mob yog xa mus rau cov tshuaj uas siv qee cov receptors, noob caj noob ces lossis cov proteins tseem ceeb ua lub hom phiaj los tua cov qog hlwb hauv lub hom phiaj.