![Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC) Cov duab tshwj xeeb](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_.jpg)
Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)
Ruifu Chemical yog tus xa khoom ntawm Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) nrog cov khoom zoo, nruab nrab ntawm Apixaban (CAS: 503612-47-3).Ruifu tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, me me thiab ntau ntau muaj.Yuav Apixaban intermediates, E-mail: alvin@ruifuchem.com
| Tshuaj npe | Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate |
| Synonyms | Ethyl 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazono]acetate;(Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;2-Chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene];Apixaban-2;Apixaban impurity 3 |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 27143-07-3, ib |
| Molecular Formula | C11H13ClN2O3 |
| Molecular Luj | 256,69 g / mol |
| Melting Point | 94 ℃ |
| Qhov ntom | 1.23 |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Qeb | Apixaban (CAS: 503612-47-3) |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Lub teeb daj rau daj hmoov | Ua raws |
| Poob rau ziab | <0.50% | 0.23% |
| Purity / Analysis Method | ≥99.0% (HPLC) | 99.3% |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj & ua raws li cov lus qhia tshwj xeeb | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Daim ntawv teev cov kuab tshuaj siv nyob rau hauv Manufacturing
| Tsis muaj. | Lub npe | CAS Nr. | Molecular Formula |
| 1 | Ethyl Acetate | CAS: 141-78-6 Nr | C4H8O2 |
| 2 | Dichloromethane | CAS: 75-09-2 Nr | CH 2 Cl 2 |
| 3 | Ethyl cawv | CAS: 64-17-5 Nr | C2H5OH |
5.3.1 Cov tsos: Nws yuav tsum yog lub teeb daj mus rau daj hmoov.Pom pom, nteg kom muaj nuj nqis ntawm cov khoom kuaj (tsis muaj qhov hnyav) hauv lub tais huv si ntawm lub ntsej muag dawb (xws li ntawv dawb) hauv qab lub teeb ntuj.
5.3.2 Kev Taw Qhia: 1H-NMR muaj cov qauv zoo ib yam li tus qauv.10 ~ 15mg ntawm cov qauv raug hnyav rau hauv lub raj sib nqus hlau, thiab 0.5mL ntawm deuterium DMSO tau ntxiv kom yaj tag nrho cov qauv, thiab tom qab ntawd sim nrog lub ntsuas hluav taws xob sib nqus ntawm ntau tshaj 400MHz.
5.3.3 Poob ntawm kev ziab: Ntsuas tus qauv txog 1.0g thiab qhuav rau 3h hauv qhov cub kom qhuav ntawm 85 ℃.Kev ua haujlwm tshwj xeeb rau kev suav qhov poob phaus yuav tsum ua raws li cov kev cai ntawm SOP-AP-QC-002-01 rau Kev Txiav Txim Siab Kev Txiav Txim Siab.
5.3.4.1 Chromatographic tej yam kev mob:
Test reagents: 1) acetonitrile rau chromatography 2) purified dej 3) phosphoric acid
Kem: WondaCract ODS-2 4.6 * 250mm * 5um (8520-39993)
Txawb theem: A: Ntsuas ntsuas 1.0ml phosphoric acid thiab 1000ml dej, lim ultrasonic degassing.
B: Acetonitrile.
Gradient txheej txheem: cov lus hauv qab no
Lub sij hawm mobile theem A (%) Txawb theem B (%)
39010 ib
10 2575 ib
200 100
25 0100
Ntes: 210nm
Kem kub: 35 ℃
Flow ceev: 1.0ml / min
Qauv loj: 5µl
5.3.4.2 Kev npaj daws teeb meem:
5.3.4.3 Diluent: acetonitrile
5.3.4.4 Cov tshuaj dawb: diluent yuav tsum tau siv los ua cov tshuaj dawb.
5.3.4.5 Test khoom tov: Ntsuas cov khoom kuaj txog 12.5mg nyob rau hauv ib lub raj mis 25ml volumetric thiab yaj nws nrog diluent mus rau lub teev.
5.3.4.6 Cov txheej txheem kev ua haujlwm: Tom qab lub hauv paus ntawm cov cuab yeej ruaj khov, ib mus rau ob qhov kev txhaj tshuaj ntawm cov tshuaj dawb huv yog siab heev, thiab tom qab ntawd cov kev daws teeb meem ntawm cov khoom kuaj tau txheeb xyuas.Lub chromatogram tau txais kev cawmdim thiab tshuaj xyuas, lub ncov dawb paug yog txiav tawm, thiab lub ntsiab ncov purity thiab ib qho impurity tshwm sim ntawm chromatogram ntawm cov khoom kuaj tau kaw los ntawm thaj chaw normalization txoj kev.Tom qab kev tsom xam, lub chromatogram tau luam tawm.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) yog siv los ua ib qho nruab nrab hauv kev sib txuas ntawm Apixaban (CAS: 503612-47-3).Apixaban yog hom tshiab ntawm qhov ncauj qhov tseem ceeb Xa inhibitor sib koom ua ke tsim los ntawm Bristol-Myers Squibb thiab Pfizer.Lub npe lag luam yog Erroto.Nws yog ib yam tshiab ntawm qhov ncauj anticoagulant.Los ntawm inhibiting ib qho tseem ceeb coagulation factor Xa, apixaban tuaj yeem tiv thaiv kev tsim cov thrombin thiab thrombosis.Apixaban yog tsim los ntawm Bristal-Myers squibb Company.Nws muaj bioavailability zoo thiab siab selectivity.Nws tau teev nyob rau hauv Suav teb xyoo 2013. Apixaban muaj kev nyab xeeb, qhov ua tau ntawm kev siv tshuaj sib cuam tshuam me me, thiab muaj ntau txoj hauv kev los tshem tawm nws, uas yuav tsum tau siv rau hauv cov pab pawg tshwj xeeb uas muaj kab mob siab lossis raum ua haujlwm puas tsuaj.
![Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_-300x300.jpg)
