CAS 274901-16-5 Purity ≥99.0% (HPLC) API
Chaw tsim tshuaj paus Supply Related Intermediates:
CAS: 274901-16-5 Nr
3-Amino-1-Adamantanol CAS: 702-82-9
L-Prolinamide CAS: 7531-52-4
Boc-L-Proline CAS: 15761-39-4
(2S)-1-(Chloroacetyl)-2-Pyrrolidinecarbonitrile CAS: 207557-35-5
| Synonyms | LAV-237 |
| CAS Nr | 274901-16-5 |
| CAT Number | RF-API 30 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
| Molecular Formula | C17H25N3O2 |
| Molecular Luj | 303.4 ib |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb Crystalline hmoov |
| Kev txheeb xyuas | IR, HPLC: Yuav tsum ua raws li Tus Qauv Siv |
| Specific Optical Rotation | -82.0 ° rau -92.0 ° |
| Melting Point | 148.0 ~ 152.0 ℃ |
| Poob rau ziab | ≤0.50% |
| Residue ntawm Ignition | ≤0.10% |
| Hnyav Hlau | ≤ 20ppm |
| Sulfate | ≤ 0.02% |
| Chloride | ≤ 0.05% |
| Chiral impurity | R-Isomer impurity ≤0.50% |
| Residual Solvents | |
| Cov tshuaj acetonitrile | ≤410ppm |
| Dichloromethane | ≤600ppm |
| Isopropyl cawv | ≤5000ppm |
| Related Impurities | Los ntawm HPLC |
| impurity A | ≤ 0.15% |
| Impurity B | ≤ 0.15% |
| Cov impurity C | ≤ 0.20% |
| Lwm Ib Leeg Impurity | ≤0.10% |
| Tag nrho cov impurities | ≤ 1.00% |
| Purity / Analysis Method | ≥99.0% (HPLC) |
| Test Standard | Enterprise Standard |
| Kev siv | API, Hom 2 Mob ntshav qab zib mellitus (T2DM) |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom thiab cov chaw muag khoom ntawm API (CAS: 274901-16-5) nrog cov khoom zoo.API CAS: 274901-16-5 Nr.yog ib qho tshuaj tiv thaiv qhov ncauj los tiv thaiv hyperglycemic (cov tshuaj tiv thaiv kab mob ntshav qab zib) ntawm cov tshuaj tshiab dipeptidyl peptidase-4 (DPP-4) inhibitor chav kawm ntawm cov tshuaj.Nws tau tsim los ntawm Novartis (Novartis) Pharmaceutical Co., Ltd, yog lwm qhov ncauj tswj hwm inhibitor ntawm Dipeptidyl peptidase-IV.Hauv xyoo 2008, nws tau pom zoo rau kev lag luam hauv European Union rau kev kho mob ntshav qab zib hom 2.API (CAS: 274901-16-5) inhibits qhov tsis ua haujlwm ntawm GLP-1 thiab GIP los ntawm DPP-4, tso cai rau GLP-1 thiab GIP los ua kom muaj zog ntawm cov tshuaj insulin hauv beta hlwb thiab txo qis glucagon tso tawm los ntawm alpha hlwb ntawm lub hlwb. islets ntawm Langerhans nyob rau hauv lub txiav.API (CAS: 274901-16-5) tau pom tias txo qis hyperglycemia hauv hom 2 mob ntshav qab zib mellitus.
