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Ibrutinib Intermediate CAS 330792-70-6 Purity > 98.0% (HPLC) Featured duab
  • Ibrutinib Intermediate CAS 330792-70-6 Purity > 98.0% (HPLC)

Ibrutinib Intermediate CAS 330792-70-6 Purity > 98.0% (HPLC)

Lus piav qhia luv luv:

5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile

CAS: 330792-70-6 Nr

Purity:> 98.0% (HPLC)

Cov tsos mob: Tawm-dawb mus rau lub teeb daj hmoov

Intermediate of Ibrutinib (CAS: 936563-96-1) 

Hu rau: Dr. Alvin Huang

Txawb/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Product Detail

Yam khoom

Khoom cim npe

Intermediates ntawm Ibrutinib:

Ibrutinib CAS Nr .: 936563-96-1
3-Hydroxypiperidine CAS Nr .: 6859-99-0
1-Boc-3-Hydroxypiperidine CAS Nr .: 85275-45-2
(S)-1-Boc-3-Hydroxypiperidine CAS Nr .: 143900-44-1
4-Phenoxybenzoic Acid CAS 2215-77-2 Nr
4-Phenoxyphenylboronic Acid CAS Nr .: 51067-38-0
4-Aminopyrazolo [3,4-d] pyrimidine CAS 2380-63-4 Nr
4-Amino-3-Iodo-1H-Pyrazolo [3,4-d] pyrimidine CAS Nr .: 151266-23-8
Ibrutinib Deacryloylpiperidine CAS Nr .: 330786-24-8
5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile CAS Nr .: 330792-70-6

Chemical Properties:

Tshuaj npe 5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Synonyms Ibrutinib Intermediate N-3;3-Amino-5-(4-Phenoxyphenyl) pyrazole-4-Carbonitrile;3-Amino-4-Cyano-5-(4-Phenoxyphenyl) pyrazole;5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
CAS Nr 330792-70-6
Tshuag xwm txheej Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons
Molecular Formula C16H12N4O
Molecular Luj 276.29 ib
Qhov ntom 1.37 ± 0.10g / cm3
COA & MSDS Muaj
Keeb kwm Shanghai, Suav
Hom Ruifu Tshuaj

Specifications:

Yam khoom Specifications
Qhov tshwm sim Off-White to Light Yellow Powder
Purity / Analysis Method > 98.0% (HPLC)
Poob rau ziab <1.00%
Residue ntawm Ignition <0.50%
Tag nrho cov impurities <2.00%
Heavy Metals (raws li Pb) <20 ppm
1 H NMR Spectrum Raws li tus qauv
Test Standard Enterprise Standard
Kev siv Intermediate of Ibrutinib (CAS: 936563-96-1)

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo.

Qhov zoo:

1

FAQ:

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330792-70-6 - Daim ntawv thov:

5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile (CAS: 330792-70-6) yog ib qho nruab nrab ntawm Ibrutinib (CAS: 936563-96-1).Ibrutinib qhia tau hais tias muaj zog thiab irreversible inhibitory nyhuv thiab xaiv rau Btk enzymatic kev ua si.Nyob rau hauv BCR txoj kev-activated DOHH2 cell kab, Ibrutinib inhibits autophosphorylation ntawm Btk, phosphorylation ntawm Btk lub physiological substrate PLCγ, thiab phosphorylation ntawm downstream kinase, ERK nrog IC50 ntawm 11 nM, 29 nM, thiab 13.Ibrutinib nthuav tawm cov koob tshuaj tseem ceeb thiab nyob ntawm lub sijhawm ua haujlwm ntawm cytotoxicity hauv cov kab mob lymphocytic leukemia (CLL) ntev.Tsis tas li ntawd, Ibrutinib induces cell tuag nyob ntawm caspase txoj kev ua kom thiab antagonizes lub peev xwm ntawm CLL hlwb kom proliferate tom qab TLR signaling.

Sau koj cov lus ntawm no thiab xa tuaj rau peb