CAS 361442-04-8 Purity > 99.0% (HPLC) API

Lus piav qhia luv luv:

Lub ntsiab lus: BMS-477118;Onglyza

CAS: 361442-04-8 Nr

Purity:> 99.0% (HPLC)

Cov tsos mob: Dawb hmoov

API, Siab Zoo, Kev Lag Luam Ntau Lawm

E-Mail: alvin@ruifuchem.com

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Product Detail

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Nqe lus piav qhia:

Ruifu Chemical Supply Related Intermediates
CAS Nr .: 361442-04-8
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2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Chemical Properties:

Synonyms	BMS-477118;Onglyza;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo[3.1.0] hexane-3-Carbonitrile;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxytricyclo [3.3.1.13,7]dec-1-yl)acetyl]-2-Azabicyclo[3.1.0] hexane -3-Carbonitrile
CAS Nr	361442-04-8
CAT Number	RF-PI 1991
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons
Molecular Formula	C18H25N3O2
Molecular Luj	315.41 Nws
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Dawb hmoov
tsw	Yam ntxwv
kev txheeb xyuas	A: IR B: HPLC Retention Time
Purity / Analysis Method	> 99.0% (HPLC)
Clarity ntawm Kev daws Dej	Pob tshab, tsis muaj xim, tsis muaj teeb meem ncua
Sieve Analysis	100% Pass 80 Mesh
Melting Point	202.0 ~ 212.0 ℃
Poob rau ziab	<0.50%
Sulfated tshauv	<0.20%
Kev sib hloov tshwj xeeb	+174.0° ~ + 186.0°
Ib leeg Impurity	<0.50%
Tag nrho cov impurities	<1.00%
Hnyav Hlau	<10ppm
Arsenic (As)	<2.0ppm
Lead (Pb)	<1.0ppm
Cadmium (Cd)	<1.0ppm
Residual Solvents	<100ppm
Residual Tshuaj tua kab	Tsis zoo
Microbiology
Tag Nrho Phaj suav	<1000cfu/g
Poov & Pwm	<100cfu/g
E. Coli	Tsis zoo
S. Aureus	Tsis zoo
Salmonella	Tsis zoo
Txee lub neej	24 lub hlis txij hnub tsim khoom yog tias khaws cia kom raug
Test Standard	Enterprise Standard
Kev siv	API;Hom 2 Mob ntshav qab zib mellitus

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo

Qhov zoo:

FAQ:

Daim ntawv thov:

(BMS-477118) (CAS: 361442-04-8) yog lub zog, xaiv, thim rov qab, sib tw thiab qhov ncauj nquag dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor.BMS-477118 muaj qhov peotential rau hom 2 mob ntshav qab zib mellitus tshawb fawb.BMS-477118Nws yog hom 2 mob ntshav qab zib hom 2 uas tuaj yeem tsim cov tshuaj insulin ntau dua tom qab noj mov.Nws tau mus txog los ntawm kev koom tes ntawm AstraZeneca thiab Bristol-Myers Squibb Company thiab belongs rau DPP-IV inhibitor.BMS-477118plays lub luag hauj lwm los ntawm inhibiting GLP-l degradation.GLP-I yog cov tshuaj hormones tsim nyob rau hauv txoj hnyuv tom qab noj mov.Nws tuaj yeem tswj hwm qhov tso tawm ntawm insulin thiab ntxiv dag zog rau kev siv cov piam thaj hauv cov ntaub so ntswg peripheral.Cov tshuaj ib leeg ntawm BMS-477118 tuaj yeem txhim kho kev tswj ntshav qabzib thiab cov tshuaj sib xyaw ua ke ntawm BMS-477118 nrog Metformin, Sulfonylurea thiab Thiazolidinediones tuaj yeem txhim kho cov nyhuv curative.Nws ua rau muaj kev pheej hmoo tsawg ntawm hypoglycemia thiab nws cov kev cuam tshuam tsis zoo zoo ib yam li cov placebo, uas qhia tau tias muaj kev zam zoo dua.Lub Xya Hli 31, 2009, BMS-477118 ntsiav tshuaj (Onglyza), cov tshuaj tshiab ntawm hom 2 mob ntshav qab zib, koom ua ke tshawb fawb thiab tsim AstraZeneca thiab Bristol-Myers Squibb tau pom zoo los ntawm US FDA.Nws tuaj yeem noj ib hnub ib zaug los kho mob ntshav qab zib hom 2 nrog rau kev tswj kev noj zaub mov thiab kev tawm dag zog.