5-(2-Pyridyl)-1,2-Dihydropyridin-2-one CAS 381233-78-9 Perampanel Intermediate Purity > 98.0% (HPLC)
Shanghai Ruifu Tshuaj Co., Ltd. (CAS: 381233-78-9) nrog cov khoom zoo, nruab nrab ntawm Perampanel (CAS: 380917-97-5).Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Perampanel intermediates,Please contact: alvin@ruifuchem.com
| Tshuaj npe | 5-(2-Pyridyl)-1,2-Dihydropyridin-2-ib |
| Synonyms | [2,3'-Bipyridin]-6'(1'H)-ib;5-(Pyridin-2-yl)pyridin-2(1H)-ib;5-(Pyridin-2-yl)-2(1H)-Pyridone;5-(2-Pyridyl)pyridin-2(1H)-ib;5-Pyridin-2-yl-1H-Pyridin-2-ib;5-(Pyridin-2-yl)-1,2-Dihydropyridin-2-ib;Perampanel impurity 1 |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 381233-78-9 |
| Molecular Formula | C10H8N2O |
| Molecular Luj | 172.18 g / mol |
| Melting Point | 71.0 ~ 75.0 ℃ |
| Qhov ntom | 1.221 ± 0.06g / cm3 |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Qeb | Intermediate of Perampanel (CAS: 380917-97-5) |
| Txee lub neej | 24 Lub Hlis yog khaws cia kom raug |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb rau Yuav luag Dawb Hmoov | Dawb hmoov |
| Purity / Analysis Method | > 98.0% (HPLC) | 99.7% |
| Dej los ntawm Karl Fischer | <1.00% | 0.58% |
| Ib leeg Impurity | <1.00% | Ua raws |
| Tag nrho cov impurities | <2.00% | 0.30% |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj thiab ua raws li cov lus qhia tshwj xeeb | |
| Daim ntawv thov | Intermediate of Perampanel (CAS: 380917-97-5) | |
Pob:Fluorinated Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav thiab zoo-ventilated warehouse kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Khoom: Dawb rau Yuav luag Dawb Hmoov
Cov kuab tshuaj: Tetrahydrofuran, Toluene, Ethylacetate, Ethanol, Methanol, tert-Butyl Methyl Ether, Petroleum Ether, n-Hexane, Dichloromethane
Kos: Cov Khoom Siv: Siv cov khoom no thiab dilute nws nrog diluent (mobile theem dej: methanol (50∶50)) los ua cov tshuaj uas muaj txog 0.5mg ib 1ml raws li cov khoom siv tshuaj ntsuam xyuas.Raws li kev ua haujlwm siab ua kua chromatography (Suav Pharmacopoeia 2010 Edition II Appendix Ⅴ D), silica gel (ZORBAX SB-C18 4.6 × 250mm, 5m) tau siv los ua tus muab tub lim.Txawb theem A yog dej, mobile theem B yog methanol, thiab nrhiav tau wavelength yog 254nm.Tus nqi ntws yog 1.0ml / min thiab qhov kub ntawm sab hauv yog chav tsev kub.5μl ntawm cov tshuaj ntsuam xyuas tau raug ntsuas kom raug thiab txhaj rau hauv cov kua chromatograph los sau cov chromatogram.Raws li txoj kev normalization ntawm cheeb tsam, cov ntsiab lus ntawm cov khoom no tsis tsawg dua 98%.Yog hais tias muaj impurity peaks nyob rau hauv lub chromatogram ntawm cov tshuaj ntsuam xyuas cov khoom, tus neeg impurity ncov cheeb tsam yuav tsum tsis txhob ntau tshaj 1.0%, thiab cov sum ntawm impurity ncov cheeb tsam yuav tsum tsis txhob ntau tshaj 2.0%.
Moisture: Siv cov khoom no, siv cov ntsuas dej noo, raws li Karl Fischer txoj kev (Suav Pharmacopoeia 2010 tsab II Appendix Ⅷ M thawj txoj kev A) kev txiav txim siab, cov ntsiab lus noo noo yuav tsum tsis pub tshaj 1.0%.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
5-(2-Pyridyl)-1,2-Dihydropyridin-2-one ([2,3'-Bipyridin]-6'(1'H)-ib) (CAS: 381233-78-9), ib qho nruab nrab ntawm Perampanel (CAS: 380917-97-5).Perampanel (daim ntawv tso cai nyob rau hauv 2012) yog ib tiam thib peb AED paub nrog lub npe tswv ntawm Fycompa® (Eisai, Hatfield) hauv UK thiab Banzel® (Eisai, Hatfield) hauv Tebchaws Meskas.Adjunctive kev kho mob ntawm focal qaug dab peg nrog los yog tsis muaj lwm yam generalization thiab thawj generalized tonic-clonic qaug dab peg.Thaum Lub Kaum Hli 2012, US FDA tau pom zoo perampanel rau kev kho mob ntawm qee qhov pib qaug dab peg hauv cov neeg mob vwm uas muaj hnub nyoog tsawg kawg 12 xyoos.Perampanel yog thawj tus AMPA receptor antagonist kom tau txais FDA pom zoo raws li AED.AMPA glutamate receptors feem ntau pom ntawm postsynaptic neurons hauv lub hlwb.Raws li kev xaiv, tsis muaj kev sib tw antagonist ntawm AMPA, parampanel tiv thaiv ion channel qhib thiab txo qis kev nthuav tawm ntawm qhov ua tau zoo.
