Tom ntej: Lapatinib Ditosylate Monohydrate CAS 388082-78-8 Purity > 99.0% (HPLC)
Tshuaj npe | Lapatinib Ditosylate Monohydrate |
Synonyms | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine |
CAS Nr | 388082-78-8 |
Tshuag xwm txheej | Hauv Tshuag |
Molecular Formula | C29H26ClFN4O4S · 2(C7H8O3S) · H2O |
Molecular Luj | 943.48 ib |
COA & MSDS | Muaj |
Keeb kwm | Shanghai, Suav |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Pleev daj rau daj crystalline hmoov |
Purity / Analysis Method | ≥99.0% (HPLC) |
Melting Point | 240.0 ~ 242.0 ℃ |
Moisture (KF) | 1.9 ~ 2.4% |
Ib leeg Impurity | ≤0.50% |
Tag nrho cov impurities | ≤ 1.00% |
Heavy Metals (raws li Pb) | ≤ 20ppm |
Test Standard | Enterprise Standard |
Kev siv | API;Rau kev kho mob ntawm cov neeg mob cancer mis |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo
Lapatinib Ditosylate Monohydrate (CAS: 388082-78-8) yog ditosylate ntsev ntawmCAS: 231277-92-2 Nr, ib qho hluavtaws, qhov ncauj-active quinazoline nrog muaj peev xwm ua haujlwm antineoplastic.Nws reversibly thaiv phosphorylation ntawm epidermal loj hlob yam receptor (EGFR), ErbB2, thiab Erk-1 thiab-2 thiab AKT kinases;Nws kuj inhibits cyclin D protein ntau hauv tib neeg qog cell kab thiab xenografts.EGFR thiab ErbB2 tau cuam tshuam rau kev loj hlob ntawm ntau hom qog.Nws tau tsim los rau kev kho mob siab lossis metastatic HER2 (ErbB2) zoo mob qog noj ntshav hauv cov poj niam uas tau txais kev kho mob ua ntej.Cov tshuaj tau tshawb pom thiab tsim los ntawm GlaxoSmithKline.