TMC207 CAS 843663-66-1 Purity > 99.5% (HPLC)
| Tshuaj npe | TMC 207 |
| Synonyms | TMC-207, R207910;Sirturo;(αS,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1-(6-Bromo-2-methoxyquinolin-3-yl)-4-dimethylamino-1-phenyl-2-(1-naphthyl) 2-butanol |
| CAS Nr | 843663-66-1 |
| CAT Number | TIAB SA 2336 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C32H31BrN2O2 |
| Molecular Luj | 555.516 ib |
| Melting Point | 104 ℃ |
| Qhov ntom | 1.322 ± 0.06 g / cm3 |
| rhiab heev | Hygroscopic.Lub teeb Sensitive, Cua Sensitive |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb los yog Off-White hmoov |
| Purity / Analysis Method | > 99.5% (HPLC) |
| Poob rau ziab | <0.50% |
| Residue ntawm Ignition | <0.20% |
| Txhua tus neeg impurity | <0.10% |
| Isomer | <0.10% |
| Tag nrho cov impurities | <0.50% |
| Heavy Metals (raws li Pb) | <20 ppm |
| Arsenic (As) | <2.0ppm |
| Infrared Spectrum | Raws li tus qauv |
| Proton NMR Spectrum | Raws li tus qauv |
| Test Standard | Enterprise Standard |
| Kev siv | API |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo
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Kev lag luam loj?Feem ntau xa tawm mus rau North America, Is Nrias teb, Russia, Kauslim Teb, Nyiv, thiab Europe, thiab lwm yam.
ZooKev lees paub?Kev ntseeg tau zoo, kev tswj xyuas nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
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Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Kev cai Synthesis?Muaj peev xwm muab cov kev pab cuam synthesis.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
(CAS: 843663-66-1), (lub npe hu ua TMC207 thiab R207910), pauv raws li lub npe lag luam Sirturo, yog ib qho tshiab diarylquinoline antimycobacterial tshuaj uas cuam tshuam rau tuberculosis los ntawm inhibiting kev ua ntawm M. tuberculosis ATP synthase proton twj.ATP synthesis ntawm mycobacteria exerts antibacterial thiab bactericidal teebmeem.Clinically siv los kho tus neeg laus multidrug-resistant tuberculosis (MDR-PTB).TMC207 muaj tib yam kab mob bactericidal tiv thaiv M. tuberculosis rhiab hom kab mob thiab resistant hom, thiab kuj muaj zoo sterilization nyhuv ntawm dormant kab mob.Thaum Lub Kaum Ob Hlis 2012, US FDA tau pom zoo TMC207 ua ib feem ntawm kev sib xyaw ua ke rau kev kho mob ntau yam tshuaj tiv thaiv tuberculosis (MDRTB).TMC207 yog thawj cov tshuaj pom zoo rau MDR-TB thiab yog thawj qhov kev pom zoo los ntawm cov chav kawm tshiab ntawm cov tshuaj tiv thaiv kab mob hauv 40 xyoo dhau los.Vim tias qhov xav tau kev kho mob siab rau kev kho mob MDR-TB, FDA tau tso cai TMC207 nrawm nrawm raws li cov txiaj ntsig ntawm Phase II, muab cov neeg mob nkag mus rau cov tshuaj thaum muaj kev tshawb fawb soj ntsuam ntxiv.TMC207 yog ib qho diarylquinoline uas tau tshawb pom los ntawm lub siab-throughput, tag nrho-cell tshuaj ntsuam lub tswv yim nrog Mycobacterium smegmatis siv los ua tus surrogate rau M. tuberculosis.TMC207 yog ib qho enantiomer ntawm kev tshuaj ntsuam thawj zaug.TMC207 muaj zog thiab xaiv kev ua si tiv thaiv mycobacteria, thiab muaj zog tiv thaiv ob qho tib si tshuaj-rhiab thiab tshuaj-resistant M. tuberculosis.Lub mechanism ntawm kev txiav txim ntawm TMC207 yog tshwj xeeb ntawm cov tshuaj tiv thaiv TB thiab koom nrog inhibition ntawm mycobacterial ATP synthase;Nws tsis nquag tawm tsam tib neeg ATP synthase.TMC207 muaj nyob rau hauv vivo cov haujlwm hauv ntau cov qauv ua ntej ntawm tus kab mob TB, ib leeg thiab ua ke nrog lwm cov tshuaj tiv thaiv kab mob, thiab muaj cov kab mob bactericidal hauv cov qauv tsim kab mob TB.TMC207 yog synthesized nyob rau hauv tsib kauj ruam los ntawm 3-Phenylpropionic Acid thiab para-Bromoaniline.Tom qab amide tsim, kev kho mob nrog POCl3 thiab DMF nyob rau hauv Vilsmeier-Hack tej yam kev mob muab 2-Chloroquinoline khoom.Kev kho mob nrog sodium methoxide, ua raws li condensation nrog 3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-ib, thiab kev sib cais ntawm isomers muab TMC207.
