Crizotinib Intermediate CAS 877399-00-3 Purity ≥98.0% (HPLC) thiab ≥99.0%
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim tshuaj paus ntawm (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00) -3) nrog cov khoom zoo, nruab nrab ntawm Crizotinib (CAS: 877399-52-5).Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Crizotinib Intermediate,Please contact: alvin@ruifuchem.com
| Tshuaj npe | (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine |
| Synonyms | Crizotinib Intermediate;Crizotinib Bromide impurity;5-Bromo-3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]-2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amine |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 877399-00-3 |
| Molecular Formula | C13H10BrCl2FN2O |
| Molecular Luj | 380.04 g / mol |
| Melting Point | 108.0 txog 113.0 ℃ |
| Qhov ntom | 1.643 ib |
| COA & MSDS | Muaj |
| Qauv | Muaj |
| Keeb kwm | Shanghai, Suav |
| Qeb | Intermediate of Crizotinib (CAS: 877399-52-5) |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Lub teeb daj rau daj hmoov rau siv lead ua | Ua raws |
| Melting Point | 108.0 txog 113.0 ℃ | Ua raws |
| Purity (HPLC Thaj Chaw) | ≥98.0% | 99.1% |
| Enantiomeric Excess (EE) | ≥99.0% | 99.5% |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom no tau raug kuaj & ua raws li cov specifications | |
| Txee lub neej | 2 Xyoo yog khaws cia kom raug | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
(R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00-3) yog siv los ua ib qho nruab nrab ntawm Crizotinib (CAS: 877399-52-5).
Crizotinib yog ib qho tshuaj tiv thaiv kabmob kheesxaws ua ib qho alk (anaplastic lymphoma kinase) thiab ros1 (c-ros oncogene 1) inhibitor, tau pom zoo rau kev kho mob ntawm qee cov qog nqaij hlav tsis me me hauv lub ntsws (NSCLC) hauv Tebchaws Meskas thiab lwm lub tebchaws, thiab tau kawm ntau yam kev sim nws txoj kev nyab xeeb thiab kev ua tau zoo hauv anaplastic cell lymphoma, neuroblastoma, thiab lwm cov qog nqaij hlav hauv cov neeg laus thiab menyuam yaus.
Crizotinib yog ib hom tshuaj kho mob rau cov qog nqaij hlav qog nqaij hlav me me uas tsim los ntawm Pfizer, Tebchaws Asmeskas, secorri yog ib qho tshuaj tiv thaiv thiab ua rau lub sijhawm nyob rau hauv kev kho mob rau lub ntsws cancer.Nws tau pom zoo rau kev lag luam hauv Tebchaws Meskas thaum Lub Yim Hli 2011 thiab tau sau rau hauv thoob ntiaj teb cov txheej txheem kho mob ntsws cancer thaum kawg ntawm lub xyoo ua cov tshuaj thawj zaug rau cov neeg mob ALK-zoo.Kev pom zoo nrog Crizotinib yog thawj txoj kev kuaj mob caj ces siv fluorescence hauv situ hybridization (FISH)-VSIs ALK Break Apart FISH Probe Kit, qhov no yog txoj kev siv tam sim no hauv ntiaj teb kev sim tshuaj ntsuam xyuas EML4-ALK fusion genes hauv NSCLC.Qhov kev sim no yuav pab txheeb xyuas cov neeg mob uas yuav tau txais txiaj ntsig los ntawm kev kho Crizotinib.
Crizotinib yog ib qho kev xaiv tyrosine kinase receptor inhibitor siv rau hauv kev kho mob ntawm cov neeg mob uas tau xaiv los ntawm cov mob qog nqaij hlav tsis me me.Nws yog dual ATP kev sib tw inhibitor ntawm tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) thiab ALK (cellular IC50 = 20 nM), ob qho tib si yog lub hom phiaj tseem ceeb rau kev kho mob qog noj ntshav.Thaum Crizotinib raug kuaj rau kev xaiv piv rau lwm cov kinases nws tau pom tias muaj enzyme IC50's hauv 100-fold ntau ntawm c-MET rau 13 ntawm 120 kinases kuaj.Hauv kev soj ntsuam ntawm tes, Crizotinib tau pom tias inhibit RON (recepteur d'origine nantais) kinase nrog 10-fold selectivity qhov rais tshaj c-MET.Ua ke, tus neeg sawv cev no inhibits qog cell loj hlob.XALKORI® (Crizotinib) yog ib hom tshuaj uas siv los kho cov neeg uas tsis yog mob qog noj ntshav me me (NSCLC) uas tau kis mus rau lwm qhov ntawm lub cev thiab yog tshwm sim los ntawm qhov tsis xws luag hauv cov noob hu ua ALK (anaplastic lymphoma kinase) lossis ib lub noob hu ua ROS1.Nws tsis paub tias XALKORI muaj kev nyab xeeb thiab siv tau rau cov menyuam yaus.
