1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 Purity ≥98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm 1-Boc-4-(4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) nrog cov khoom zoo, nruab nrab ntawm Crizotinib (CAS: 877399- 52-5).Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Tshuaj npe | 1-Boc-4-(4-Bromopyrazol-1-yl)piperidine |
| Synonyms | Crizotinib-D;tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylic Acid tert-Butyl Ester;1-tert-Butoxycarbonyl-4-(4-Bromopyrazol-1-yl)piperidine;1-(4-Boc-Piperidino)-4-Bromopyrazole;1-Boc-4-(4-Bromo-1-Pyrazolyl)piperidine;4-Bromo-1-(N-Boc-Piperidin-4-yl)-1H-Pyrazole;tert-butyl 4-(4-Bromo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;1-(4-Boc-1-Piperidinyl)-4-Bromopyrazole;Crizotinib impurity 4 |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 877399-50-3 |
| Molecular Formula | C13H20BrN3O2 |
| Molecular Luj | 330.23 g / mol |
| Melting Point | 77.0 txog 81.0 ℃ |
| Qhov ntom | 1.43 ib |
| Solubility | Soluble hauv Methanol |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Qeb | Intermediate of Crizotinib (CAS: 877399-52-5) |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb Khoom | Dawb Khoom |
| Melting Point | 77.0 txog 81.0 ℃ | Ua raws |
| Dej los ntawm Karl Fischer | <0.50% | 0.11% |
| Purity / Analysis Method | ≥98.0% (HPLC) | 99.3% |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| Pawg | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj & ua raws li cov lus qhia tshwj xeeb | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Hazard Symbols Xn - Ua phem
Risk Codes 22 - Ua phem yog tias nqos tau
1-Boc-4-(4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) yog siv los ua ib qho nruab nrab ntawm Crizotinib (CAS: 877399-52-5).Crizotinib (lub npe lag luam Xalkori,) yog cov tshuaj tiv thaiv kab mob qog noj ntshav ua haujlwm raws li ALK (anaplastic lymphoma kinase) thiab ROS1 (c-ros oncogene 1) inhibitor, tau pom zoo rau kev kho mob ntawm qee qhov mob ntsws tsis zoo hauv lub ntsws (NSCLC) hauv Asmeskas thiab qee lub tebchaws, thiab tau txais kev sim tshuaj ntsuam xyuas nws txoj kev nyab xeeb thiab kev ua tau zoo inanaplastic cell lymphoma, neuroblastoma, thiab lwm yam qog nqaij hlav hauv cov neeg laus thiab menyuam yaus.
Thaum Lub Yim Hli 2011, Tebchaws Asmeskas FDA pom zoo Crizotinib (PF- 02341066) rau kev kho mob ntawm anaplastic lymphoma kinase (ALK) rov kho cov qog nqaij hlav tsis me me (NSCLC).Crizotinib yog dual ATP kev sib tw inhibitor ntawm tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) thiab ALK (cellular IC50 = 20 nM), ob qho tib si yog lub hom phiaj tseem ceeb rau kev kho mob qog noj ntshav.Thaum Crizotinib raug kuaj rau kev xaiv piv rau lwm cov kinases nws tau pom tias muaj enzyme IC50's hauv 100-fold ntau ntawm c-MET rau 13 ntawm 120 kinases kuaj.Hauv kev soj ntsuam ntawm tes, Crizotinib tau pom tias inhibit RON (recepteur d'origine nantais) kinase nrog 10-fold selectivity qhov rais tshaj c-MET.
