1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole CAS 877399-73-0 Purity ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm 1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) nrog cov khoom zoo, nruab nrab ntawm Crizotinib (CAS: 877399-52) -5).Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Tshuaj npe | 1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole |
| Synonyms | 1-Boc-4-(4-Iodo-1H-Pyrazol-1-yl)piperidine;tert-Butyl 4-(4-Iodo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;tert-Butyl 4-(4-Iodopyrazolyl)piperidinecarboxylate;Crizotinib impurity 16 |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 877399-73-0 |
| Molecular Formula | C13H20IN3O2 |
| Molecular Luj | 377.22 g / mol |
| Melting Point | 97 ℃ |
| Qhov ntom | 1.60 ± 0.10g / cm3 |
| rhiab heev | Lub teeb Sensitive |
| Cia Temp. | 2 ~ 8 ℃, Tiv thaiv los ntawm lub teeb |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Qeb | Intermediate of Crizotinib (CAS: 877399-52-5) |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb rau lub teeb daj khoom | Dawb Khoom |
| Purity / Analysis Method | ≥99.0% (HPLC) | 99.58% |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| ESI + | Ua raws | Ua raws |
| Xaus | Cov khoom tau raug kuaj & ua raws li cov lus qhia tshwj xeeb | |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) nrog cov khoom zoo, nruab nrab ntawm Crizotinib (CAS: 877399-52-5).Crizotinib yog ib hom tshuaj kho mob rau cov qog nqaij hlav qog nqaij hlav me me uas tsim los ntawm Pfizer, Tebchaws Asmeskas, secorri yog ib qho tshuaj tiv thaiv thiab ua rau lub sijhawm nyob rau hauv kev kho mob rau lub ntsws cancer.Nws tau pom zoo rau kev lag luam hauv Tebchaws Meskas thaum Lub Yim Hli 2011 thiab tau sau rau hauv thoob ntiaj teb cov txheej txheem kho mob ntsws cancer thaum kawg ntawm lub xyoo ua cov tshuaj thawj zaug rau cov neeg mob ALK-zoo.Kev pom zoo nrog Crizotinib yog thawj txoj kev kuaj mob caj ces siv fluorescence hauv situ hybridization (FISH)-VSIs ALK Break Apart FISH Probe Kit, qhov no yog txoj kev siv tam sim no hauv ntiaj teb kev sim tshuaj ntsuam xyuas EML4-ALK fusion genes hauv NSCLC.Qhov kev sim no yuav pab txheeb xyuas cov neeg mob uas yuav tau txais txiaj ntsig los ntawm kev kho Crizotinib.Hnub tim 25, qhov no yog thawj cov tshuaj siv los kho cov neeg mob uas muaj mob hauv zos lossis mob qog noj ntshav uas tsis yog mob qog noj ntshav (NSCLC) uas yog anaplastic lymphoma kinase (ALK)-zoo raws li kev txiav txim siab los ntawm SFDA-pom zoo soj ntsuam.
Crizotinib (PF-02341066) Crizotinib yog ib qho muaj zog c-Met thiab ALK inhibitor, IC50 qhov tseem ceeb hauv kev soj ntsuam ntawm tes yog 11 nM thiab 24 nM, feem.Nws tseem yog ib qho muaj zog inhibitor ntawm ROS1 nrog tus nqi Ki tsawg dua 0.025 nM.Crizotinib tuaj yeem ua rau autophagy hauv ntau hom kab mob ntsws cancer ntawm tes los ntawm inhibiting txoj hauv kev STAT3.
