CAS 945667-22-1 Purity > 99.0% (HPLC) API

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CAS: 945667-22-1 Nr

Purity:> 99.0% (HPLC)

Cov tsos mob: Dawb hmoov

API, Siab Zoo, Kev Lag Luam Ntau Lawm

E-Mail: alvin@ruifuchem.com

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Product Detail

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Ruifu Chemical Supply Related Intermediates
CAS Nr .: 361442-04-8
CAS Nr .: 945667-22-1
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(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
Tom ntej: 1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid Tert-Butyl Ester CAS 361440-67-7
2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Chemical Properties:

Synonyms	BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0] Hexane-3-Carbonitrile Hydrate
CAS Nr	945667-22-1
CAT Number	RF-PI 1992
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons
Molecular Formula	C18H25N3O2 · H2O
Molecular Luj	333.43 ib
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Dawb hmoov
kev txheeb xyuas	A: IR B: HPLC Retention Time
Purity / Analysis Method	> 99.0% (HPLC, Nyob rau hauv qhuav qhuav)
Cov ntsiab lus dej (KF)	5.3% ~ 7.3%.
Residue ntawm Ignition	<0.20%
Ib leeg Impurity	<0.50%
Tag nrho cov impurities	<1.00%
Hnyav Hlau	<10ppm
Arsenic (As)	<2 ppm
Microbiology
Tag Nrho Phaj suav	<1000cfu/g
Poov & Pwm	<100cfu/g
E. Coli	Tsis zoo
S. Aureus	Tsis zoo
Salmonella	Tsis zoo
Txee lub neej	24 Lub Hlis
Test Standard	Enterprise Standard
Kev siv	API;Siv rau Kev Kho Mob Ntshav Qab Zib Hom II

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb thiab noo noo

Qhov zoo:

FAQ:

Daim ntawv thov:

API (CAS: 945667-22-1) yog ib qho kev xaiv thiab thim rov qab dipeptidyl peptidase-4 (DPP4) inhibitor uas yuav raug siv los tsim kho mob ntshav qab zib hom 2.Nws yog ib qho kev xaiv thiab thim rov qab DPP4 inhibitor nrog IC50 ntawm 26 nM thiab Ki ntawm 1.3 nM.IC50 tus nqi: 26 nM.Lub hom phiaj: DPP4 hauv vitro: Nws muaj qhov inhibition tas li Ki ntawm 1.3 nM rau DPP4 inhibition, uas yog 10-fold muaj zog dua Sitagliptin (lwm ob DPP4 inhibitors) nrog Ki ntawm 13 thiab 18 nM.Tsis tas li ntawd, nws qhia tau hais tias ntau dua rau DPP4 dua li rau DPP8 lossis DPP9 enzymes (400- thiab 75- quav, feem).Lub active metablite ntawm nws yog ob-fold tsawg zog tshaj tus niam txiv.Ob leeg (CAS: 945667-22-1) thiab nws cov metabolite muaj kev xaiv ntau heev (> 4000-fold) rau kev tiv thaiv ntawm DPP4 piv nrog ntau yam ntawm lwm cov proteases.(CAS: 945667-22-1) txo qis qhov degradation ntawm incretin hormone glucagon-zoo li peptide-1, yog li txhim kho nws cov kev ua, thiab cuam tshuam nrog kev txhim kho β-cell muaj nuj nqi thiab kev tawm tsam ntawm glucagon secretion.in vivo: Nws muaj txiaj ntsig zoo. ntawm eliciting marked dose-dependent enhancements in glucose clearance in the dose range 0.13-1.3 mg/kg hauv ob/ob nas txheeb ze rau kev tswj.