Celecoxib CAS 169590-42-5 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Celecoxib (CAS: 169590-42-5) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Celecoxib,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Celecoxib |
| Synonyms | Celebrex;Celebra;Celecox;Onsenal;Solxa;SC-58635;SC 58635;YM-177;4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-yl]benzenesulfonamide;5-(4-Methylphenyl)-1-(4-Sulfamoylphenyl)-3-(Trifluoromethyl)pyrazole |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 169590-42-5 |
| Molecular Formula | C17H14F3N3O2S |
| Molecular Luj | 381.37 g / mol |
| Melting Point | 160.0 txog 165.0 ℃ |
| Qhov ntom | 1.43 ± 0.10g / cm3 |
| Dej Solubility | Insoluble hauv dej |
| Solubility | Soluble heev hauv Methanol;Soluble hauv Ethanol |
| COA & MSDS | Muaj |
| Qauv | Muaj |
| Keeb kwm | Shanghai, Suav |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb los yog Yuav luag Dawb Crystalline Hmoov | Ua raws |
| Assay | 98.0 ~ 102.0% | 99.8% |
| Melting Point | 160.0 txog 165.0 ℃ | 162.2 ℃ |
| Dej los ntawm Karl Fischer | <0.50% | 0.11% |
| Residue ntawm Ignition | <0.20% | 0.05% |
| Heavy Metals (Pb) | ≤ 20ppm | <10ppm |
| Celecoxib Related Compound A | <0.40% | <0.20% |
| Celecoxib Related Compound B | <0.10% | <0.10% |
| Ib tug neeg tsis paub meej impurity | <0.10% | <0.10% |
| Tag nrho impurities | <0.50% | 0.20% |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| 1 H NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom tau raug kuaj thiab ua raws li cov lus qhia tshwj xeeb | |
Pob:Fluorinated Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Celecoxib
C17H14F3N3O2S 381.4
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide;
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide [169590-42-5]
DEFINITION
Celecoxib muaj NLT 98.0% thiab NMT 102.0% ntawm C17H14F3N3O2S, xam los ntawm lub hauv paus anhydrous
IDENTIFICATION
• A. INFRARED ABSORPTION <197>: [NOTE-Methods <197A>, <197K>, lossis <197M> nyob rau hauv Infrared Absorption tej zaum yuav raug siv.]
[CEEB TOOM-Yog tias cov spectra tau pom qhov sib txawv, yaj cov tshuaj uas yuav tsum tau kuaj xyuas thiab Daim Ntawv Qhia Kev Cai Sib Cais cais hauv isopropyl cawv, evaporate kom qhuav, thiab sau cov spectra tshiab.]
• B. Lub sij hawm khaws cia ntawm lub ncov loj ntawm cov qauv kev daws teeb meem sib raug rau cov txheej txheem kev daws teeb meem, raws li tau txais hauv Assay.
QHIA
• KEV PAB CUAM
Tsis muaj: 2.7 g / L ntawm monobasic potassium phosphate hloov nrog phosphoric acid rau pH ntawm 3.0 ± 0.2
Mobile theem: Methanol, acetonitrile, thiab Buffer (3: 1: 6)
Diluent: Methanol thiab dej (3: 1)
Kev daws qhov system haum: 0.5 mg / mL ntawm USP
Celecoxib RS thiab 2.4 µg/mL txhua ntawm USP Celecoxib Related Compound A RS thiab USP Celecoxib Related Compound B RS hauv Diluent
Kev daws teeb meem: 0.5 mg / mL ntawm USP Celecoxib RS hauv Diluent
Piv txwv li: 0.5 mg / mL ntawm Celecoxib hauv Diluent
Chromatographic system
(Saib Chromatography <621>, System Suitability.)
Qauv: LC
Detector: UV 215 nm
Kem: 4.6-mm × 25-cm;5-µm ntim L11
Kem kub: 60 °
Tus nqi ntws: 1.5 mL / min
Kev txhaj tshuaj loj: 25 µL
Lub sijhawm ua haujlwm: Txog 1.5 npaug ntawm celecoxib ncov elution
Qhov system haum
Qauv: Kev daws teeb meem tsim nyog thiab kev daws teeb meem
Suitability xav tau
Kev daws teeb meem: NLT 1.8 nruab nrab ntawm celecoxib ntsig txog compound A thiab Celecoxib thiab NLT 1.8 ntawm Celecoxib thiab Celecoxib ntsig txog B, Kev daws teeb meem tsim nyog
Tus txheeb ze tus qauv sib txawv: NMT 0.73%, Standard tov
Kev tsom xam
Qauv: Cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem
Xam cov feem pua ntawm C17H14F3N3O2S hauv feem ntawm Celecoxib noj:
Result = (rU/rS) × (CS/CU) × 100
rU = ncov teb los ntawm Sample tov
rS = ncov teb los ntawm Standard tov
CS = concentration ntawm Standard tov (mg / mL)
CU = concentration of the Sample solution (mg/mL)
Kev lees txais cov qauv: 98.0% ~ 102.0% ntawm lub hauv paus anhydrous
IMPURITIES
Inorganic impurities
• Hnyav hlau: NMT 20 ppm
Diluent: Acetone thiab dej (17:3)
Standard tov: Dilute 1.0 mL ntawm Standard Lead Solution, npaj raws li qhia nyob rau hauv Heavy Metals <231>, Tshwj xeeb Reagents, nrog Diluent mus rau 20 mL.
Piv txwv li: Dissolve 0.50 g ntawm Celecoxib nyob rau hauv 20mL ntawm Diluent.
Cov tshuaj dawb: 20 mL ntawm Diluent
Kev tsom xam
Cov qauv: Cov qauv kev daws teeb meem, cov tshuaj dawb paug, thiab cov qauv kev daws teeb meem
Rau txhua qhov kev daws, ntxiv 2 mL ntawm pH 3.5 Acetate Buffer npaj raws li qhia hauv Cov Hlau Hnyav <231>, Txoj Kev I. Sib tov, thiab ntxiv rau txhua qhov tshuaj 1.2 mL ntawm thioacetamide-glycerin puag TS.Sib tov tam sim ntawd, thiab cia sawv ntsug rau 2 feeb.Dhau cov kev daws teeb meem los ntawm lub lim ntawm 0.45-µm pore loj.Sib piv cov chaw ntawm cov lim tau los ntawm txhua qhov kev daws teeb meem.
Kev lees txais cov qauv: Cov xim xim av-dub ntawm qhov chaw uas tshwm sim los ntawm cov qauv kev daws teeb meem tsis yog khaus ntau dua li qhov chaw uas tshwm sim los ntawm Cov Txheej Txheem.Qhov kev ntsuam xyuas tsis raug yog tias qhov kev daws teeb meem tsis pom cov xim xim av-dub piv rau cov tshuaj Blank.
• RESIDUE ON IGNITION <281>: NMT 0.2%, siv lub platinum crucible
Organic impurities
• PROCEDUR
Tsis muaj, Txawb theem, Diluent, System haum rau kev daws teeb meem, qauv kev daws teeb meem, thiab Chromatographic system: Ua raws li qhia hauv Kev Tshawb Fawb.
Kev daws teeb meem: 0.5 µg / mL ntawm USP Celecoxib RS hauv Diluent
Qhov system haum
Qauv: Kev daws teeb meem tsim nyog thiab kev daws teeb meem
Suitability xav tau
Kev daws teeb meem: NLT 1.8 ntawm Celecoxib ntsig txog compound A thiab Celecoxib thiab NLT 1.8 ntawm Celecoxib thiab Celecoxib ntsig txog B, Kev daws teeb meem tsim nyog
Teeb liab-rau-lub suab piv: NLT 20, Standard tov
Kev tsom xam
Qauv: Cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem
Xam cov feem pua ntawm txhua qhov impurity hauv ib feem ntawm Celecoxib noj:
Result = (rU/rS) × (CS/CU) × 100
rU = ncov teb rau txhua impurity nyob rau hauv cov qauv tov
rS = ncov teb ntawm celecoxib nyob rau hauv Standard tov
CS = concentration ntawm celecoxib nyob rau hauv Standard tov (mg / mL)
CU = concentration of Celecoxib in the Sample solution (mg/mL)
Kev lees txais
Ib tug neeg impurities: Saib Table 1.
[CEEB TOOM-Tsis quav ntsej tej impurity ncov tsawg dua 0.05%.]
Table 1
| Lub npe | Lub Sijhawm Retention Relative | Kev lees txais NMT (%) |
| Celecoxib related compound Aa | 0.9 | 0.4 |
| Celecoxib | 1.0 | — |
| Celecoxib related compound Bb | 1.1 | 0.10 |
| Tus kheej tsis meej impurity | — | 0.10 |
| Tag nrho impurities | — | 0.5 |
a 4-[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
b 4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
TSEEM CEEB
• KEV TIV THAIV DUA, Txoj Kev I <921>: NMT 0.5%, siv cov qauv 400-mg
TSEEM CEEB
• PACKAGING THIAB STORAGE: Khaws rau hauv cov thawv kaw ntom ntom, tiv thaiv lub teeb thiab noo noo.Khaws ntawm chav tsev kub
• USP REFERENCE STANDARDS <11>
USP Celecoxib RS
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
C17H14F3N3O2S 381.4
USP Celecoxib Related Compound A RS
4-[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
C17H14F3N3O2S 381.4
USP Celecoxib Related Compound B RS
4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
C17H14F3N3O2S 381.4
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
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Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
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Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
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| Hazard Cov Cim | Xn - Ua phem |
| Risk Codes | R20/21/22 - Ua phem los ntawm kev nqus pa, tiv tauj nrog daim tawv nqaij thiab yog tias nqos. |
| R52 - Ua phem rau cov kab mob hauv dej | |
| R61 - Tej zaum yuav ua rau muaj mob rau tus menyuam hauv plab | |
| R60 - Tej zaum yuav cuam tshuam fertility | |
| Kev nyab xeeb piav qhia | S22 - Tsis txhob nqus plua plav. |
| S24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag. | |
| S28 - Tom qab sib cuag nrog daim tawv nqaij, ntxuav tam sim ntawd nrog xab npum-suds ntau. | |
| S37/39 - Hnav cov hnab looj tes tsim nyog thiab tiv thaiv qhov muag / ntsej muag | |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | wb 2944937 |
| HS Code | 293590009 0 |
| Hazard Class | IRRITANT |
Celecoxib thiab Rofecoxib yog ob qho tam sim no siv COX-2 inhibitors.Ua tau zoo tsim los ntawm GD Searle & Pfizer Co. (US,) tso tawm xyoo 1999, lub npe lag luam: Celebrex.Celecoxib yog ib tug nonsteroidal, anti-inflammatory tus neeg saib xyuas nrog rau qhov tseem ceeb analgesic thiab anti-inflammatory teebmeem, ua rau qhov tsawg tshaj plaws tshwm sim ntawm lub plab hnyuv ulcers thiab lwm yam teeb meem.Siv cov chaw kho mob los kho mob osteoarthritis thiab mob caj dab thiab mob rheumatoid, nrog rau lub luag haujlwm tiv thaiv kev mob analgesic, txo cov tsos mob thiab cov tsos mob ntawm osteoarthritis thiab rheumatoid mob caj dab.
Celecoxib (CAS: 169590-42-5), Rau kev nyem thiab kev tswj ntawm osteoarthritis (OA), rheumatoid mob caj dab (RA), juvenile rheumatoid mob caj dab (JRA), ankylosing spondylitis, mob mob, thawj dysmenorrhea thiab kev kho qhov ncauj rau cov neeg mob. Nrog tsev neeg adenomatous polyposis.
Celecoxib (CAS: 169590-42-5) muaj cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob ntawm NSAIDs.Vim nws cov qauv tshuaj, nws tuaj yeem ua ke nrog COX-2, xaiv inhibiting COX-2.Nws pawg phenyl khi nrog hydrophobic channel ntawm COX-2, thiab nws cov hydrophilic sulfonamide tsim cov saw hlau hydrogen nrog 513 arginine thiab 90 histidine hauv COX-2 "sab hnab tshos."Nws kuj tseem nyob ze nrog arginine hauv COX-2120 txoj haujlwm thiab ua lub luag haujlwm hauv inhibiting COX-2 los ntawm kev hloov arachidonic acid rau prostaglandins uas ua rau muaj kev phom sij rau tib neeg lub cev. -2, Celecoxib tsis tuaj yeem nkag mus rau COX-1 molecule, thiab tsis cuam tshuam nws qhov kev hloov pauv ntawm arachidonic acid rau hauv prostaglandins. Yog li, nws muaj cov tshuaj tiv thaiv zoo thiab ua kom tsis zoo, tiv thaiv lub plab mucosa, tiv thaiv lub raum ntshav khiav, tswj cov platelet aggregation, thiab daws cov teeb meem. Cov teeb meem plab hnyuv ntawm cov NSAIDs uas nquag siv.
Celecoxib (CAS: 169590-42-5) yog qhia rau kev kho mob osteoarthritis thiab rheumatoid mob caj dab.Nws siv yog contraindicated nyob rau hauv cov neeg uas muaj hypersensitivity rau sulfonamides los yog lwm yam NSAIDs.Nws yuav tsum tau siv nrog ceev faj rau cov neeg muaj kab mob siab.Kev sib cuam tshuam tshwm sim nrog lwm cov tshuaj uas ua rau CYP2C9 (xws li rifampin rifampin) lossis sib tw rau cov metabolism los ntawm cov enzyme no (xws li fluconazole, leflunomide).Feem ntau cov kev phiv tshwm sim rau celecoxib yog me me mus rau nruab nrab GI teebmeem xws li dyspepsia, raws plab, thiab mob plab.Qhov hnyav GI thiab lub raum cuam tshuam tsis tshua muaj tshwm sim.
