Chloramphenicol CAS 56-75-7 Purity ≥99.0% (HPLC) Siab Purity
Chaw tsim tshuaj paus Supply nrog High Purity thiab Commercial Production
1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 716-61-0
1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 2964-48-9
Chloramphenicol CAS 56-75-7
| Tshuaj npe | Chloramphenicol |
| Synonyms | D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol;2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide |
| CAS Nr | 56-75-7 ib |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale mus txog Tons |
| Molecular Formula | C11H12Cl2N2O5 |
| Molecular Luj | 323.13 Nws |
| Melting Point | 149.0 ~ 153.0 ℃ (lit.) |
| rhiab heev | Lub teeb Sensitive |
| Solubility | Soluble heev hauv Ethanol, Methanol, Acetone.Soluble hauv Ether, Chloroform.Insoluble hauv Benzene.Xyaum Insoluble hauv dej |
| Shipping Condition | Shipped nyob rau hauv ambient kub |
| COA & MSDS | Muaj |
| Keeb kwm | Shanghai, Suav |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau lub teeb daj hmoov |
| Kev Taw Qhia A | Infrared Absorption |
| Kev Qhia B | Lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm Assay kev npaj sib raug rau qhov hauv chromatogram ntawm Standard npaj, raws li tau txais hauv Assay. |
| Specific Optical Rotation | +17.0° ~ + 20.0°° |
| Melting Point | 149.0 ~ 153.0 ℃ |
| Crystallinity | Ua tau raws li qhov yuav tsum tau ua |
| pH | 4.5 ~ 7.5 hli |
| Ib leeg Impurity | ≤0.50% |
| Tag nrho cov impurities | ≤ 1.00% |
| Hnyav Hlau | ≤ 20ppm |
| Arsenic | ≤1ppm |
| Poob rau ziab | ≤0.50% (105 ℃, 3 teev) |
| Residue ntawm Ignition | ≤0.10% |
| Purity / Analysis Method | ≥99.0% (HPLC) |
| Test Standard | Enterprise Standard;JP;USP |
Pob: Lub raj mis, Aluminium ntawv ci hnab, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo.
Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
Chloramphenicol muaj tsis tsawg dua 97.0 feem pua thiab tsis ntau tshaj 103.0 feem pua ntawm C11H12Cl2N2O5.
Ntim thiab khaws cia-Txuag hauv cov thawv nruj.
Labeling-Qhov twg nws yog npaj los siv rau hauv kev npaj cov tshuaj txhaj tshuaj los yog lwm yam tshuaj uas tsis muaj menyuam, daim ntawv lo hais tias nws tsis muaj menyuam lossis yuav tsum tau ua haujlwm ntxiv thaum lub sijhawm npaj cov tshuaj txhaj lossis lwm yam tshuaj tsis muaj menyuam.
USP Reference cov qauv <11>-
USP Chloramphenicol RS Nyem rau Saib Cov Qauv
Tom ntej: USP Endotoxin RS
Kev txheeb xyuas-
A: Infrared Absorption <197K>.
B: Lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm Assay kev npaj sib raug rau qhov ntawd nyob rau hauv chromatogram ntawm Standard npaj, raws li tau txais hauv Assay.
Melting ntau <741>: ntawm 149 thiab 153.
Kev sib hloov tshwj xeeb <781S>: nruab nrab ntawm +17.0 thiab +20.0.
Kuaj cov tshuaj: 50 mg, undried, ib mL, nyob rau hauv lub cev qhuav dej cawv.
Crystallinity <695>: ua tau raws li qhov yuav tsum tau ua.
Cov kab mob endotoxins 85-Qhov twg Chloramphenicol yog npaj los siv rau hauv kev npaj cov tshuaj txhaj tshuaj, nws muaj tsis pub ntau tshaj 0.2 USP Endotoxin Unit ib mg ntawm chloramphenicol.
Sterility 71- Qhov twg daim ntawv lo hais tias Chloramphenicol yog sterile, nws ua tau raws li qhov yuav tsum tau thaum kuaj raws li qhia rau Membrane Filtration nyob rau hauv Test rau Sterility ntawm cov khoom yuav tsum tau kuaj, tsuas yog siv 1 g ntawm cov khoom kuaj.
pH <791>: nruab nrab ntawm 4.5 thiab 7.5, nyob rau hauv ib qho kev ncua aqueous muaj 25 mg ib mL.
Chromatographic purity-Dissolve qhov hnyav hnyav ntawm Chloramphenicol hauv methanol kom tau txais cov tshuaj ntsuam xyuas uas muaj 10 mg ib mL.Npaj cov tshuaj USP Chloramphenicol RS hauv methanol uas muaj 10 mg rau ib mL (Standard tov A).Dilute feem ntawm Standard tov A quantitatively nrog methanol kom tau Standard tov B uas muaj 100 µg ib mL thiab Standard tov C muaj 50 µg ib mL.Siv cais 20-µL feem ntawm cov tshuaj ntsuam xyuas thiab cov qauv kev daws teeb meem B thiab C rau cov txheej nyias nyias chromatographic phaj (saib Chromatography 621), coated nrog 0.25-mm txheej ntawm chromatographic silica gel sib tov.Tsim cov chromatogram hauv cov kuab tshuaj uas muaj cov sib xyaw ntawm chloroform, methanol, thiab glacial acetic acid (79:14:7) kom txog rau thaum cov kuab tshuaj pem hauv ntej tau txav mus txog peb feem plaub ntawm qhov ntev ntawm lub phaj.Tshem lub phaj ntawm lub chamber, huab cua qhuav, thiab tshuaj xyuas nyob rau hauv luv luv-yoj UV teeb: ib qho chaw twg uas tsis yog lub hauv paus ntsiab lus ntawm qhov kev tshuaj ntsuam xyuas tsis pub tshaj qhov loj los yog siv lub ntsiab qhov chaw tau los ntawm Standard tov B (1% ), thiab cov sum ntawm cov impurities sawv cev los ntawm tag nrho cov ntawm cov chaw uas tsis yog lub hauv paus chaw, raws li kev sib piv ntawm cov intensities ntawm xws li cov chaw nrog rau cov intensity ntawm lub hauv paus ntsiab lus chaw tau los ntawm Standard kev daws teeb meem B thiab C, tsis pub tshaj 2%. .
Assay-
Txawb theem-Npaj tsim cov dej lim dej, methanol, thiab glacial acetic acid (55:45:0.1).Hloov kho yog tias tsim nyog (saib System Suitability hauv Chromatography 621).
Cov txheej txheem kev npaj- Dissolve ib qho raug hnyav kom muaj nuj nqis ntawm USP Chloramphenicol RS nyob rau hauv Mobile theem, thiab dilute quantitatively, thiab stepwise yog tias tsim nyog, nrog Mobile theem kom tau txais ib tug paub concentration ntawm txog 80 µg ib mL.Lim ib feem ntawm qhov kev daws teeb meem no los ntawm 0.5-µm lossis lim porosity zoo dua, thiab siv cov lim dej ntshiab raws li Cov Qauv Npaj.
Kev tshuaj ntsuam xyuas- Hloov txog 200 mg ntawm Chloramphenicol, ntsuas kom raug, mus rau 100-mL ntim ntim, ntxiv cov theem txawb rau ntim, thiab sib tov.Hloov 4.0 mL ntawm cov txiaj ntsig daws mus rau 100-mL ntim ntim, dilute nrog Txawb theem rau ntim, thiab sib tov.Lim ib feem ntawm qhov kev daws teeb meem no los ntawm 0.5-µm lossis lim porosity zoo dua, thiab siv cov lim ntshiab raws li kev npaj Assay.
Chromatographic system (saib Chromatography <621>)-Cov kua chromatograph yog nruab nrog 280-nm detector thiab 4.6-mm × 10-cm kem uas muaj 5-µm packing L1.Tus nqi ntws yog li 1 mL ib feeb.Chromatograph tus qauv npaj, thiab sau cov lus teb ncov raws li tau hais tseg hauv Cov Txheej Txheem: cov kab ke kev ua haujlwm tau txiav txim siab los ntawm cov tshuaj ntsuam xyuas siab tsis tsawg dua 1800 theoretical daim hlau, qhov tailing yam tsis ntau tshaj 2.0, thiab tus txheeb ze tus qauv sib txawv rau kev txhaj tshuaj replicate tsis yog. ntau tshaj 1.0%.
Cov txheej txheem-[coj-Siv qhov siab siab tshaj qhov twg cov lus teb siab kawg tau qhia.] Sib cais cov ntim sib npaug (kwv yees li 10 µL) ntawm Standard npaj thiab Assay npaj rau hauv chromatograph, sau cov chromatograms, thiab ntsuas cov lus teb rau qhov loj peaks.Xam qhov ntau, hauv mg, ntawm C11H12Cl2N2O5 hauv feem ntawm Chloramphenicol coj los ntawm cov mis:
2.5C (rU / rS)
nyob rau hauv uas C yog qhov concentration, nyob rau hauv µg ib mL, ntawm USP Chloramphenicol RS nyob rau hauv tus txheej txheem kev npaj, thiab rU thiab rS yog lub ncov cov lus teb tau los ntawm Assay npaj thiab cov Standard npaj, feem.
Chloramphenicol
C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide [56-75-7]
Chloramphenicol muaj tsis pub tsawg tshaj 980 mg (potency) thiab tsis ntau tshaj 1020 mg (potency) ib mg, xam rau lub hauv paus qhuav.Lub zog ntawm Chloramphenicol yog qhia raws li qhov loj (potency) ntawm chloramphenicol (C11H12Cl2N2O5).
Kev piav qhia Chloramphenicol tshwm sim li dawb mus rau yellowish dawb, muaju los yog crystalline hmoov.
Nws yog dawb do soluble hauv methanol thiab hauv ethanol (99.5), thiab me ntsis soluble hauv dej.
Kev txheeb xyuas (1) Txiav txim siab qhov nqus spectrum ntawm cov qauv kev daws teeb meem tau txais hauv Assay raws li qhia nyob rau hauv Ultraviolet-pom Spectrophotometry <2.24>, thiab sib piv cov spectrum nrog Reference Spectrum lossis cov spectrum ntawm cov tshuaj Chloramphenicol RS npaj rau tib yam li cov qauv kev daws teeb meem: ob qho tib si spectra pom zoo sib xws ntawm kev nqus ntawm tib lub wavelengths.
(2) Txiav txim siab qhov infrared absorption spectrum ntawm Chloramphenicol raws li qhia nyob rau hauv cov poov tshuaj bromide disk txoj kev nyob rau hauv Infrared Spectrophotometry <2.25>, thiab muab piv cov spectrum nrog cov Reference Spectrum los yog cov spectrum ntawm Chloramphenicol RS: ob qho tib si spectra pom zoo sib xws zog ntawm tib absorption. yoj tus lej.
Kev sib hloov kho qhov muag <2.49> [a]20D: +18.5 ~ + 21.5 ℃ (1.25 g, ethanol (99.5), 25 mL, 100 mm).
Melting point <2.60> 150 ~ 155 ℃
Purity (1) Cov hlau hnyav <1.07>-Tau nrog 1.0 g ntawm Chloramphenicol raws li Txoj Kev 2, thiab ua qhov kev sim.Npaj cov tshuaj tswj nrog 2.5 mL ntawm Standard Lead Solution (tsis ntau tshaj 25 ppm).
(2) Arsenic <1.11>-Npaj cov tshuaj ntsuam xyuas nrog 2.0 g ntawm Chloramphenicol raws li Txoj Kev 4, thiab ua qhov kev sim (tsis ntau tshaj 1 ppm).
(3) Lwm yam tshuaj-Dissolve 0.10 g ntawm Chloramphenicol nyob rau hauv 10 mL ntawm methanol, thiab siv cov tshuaj no raws li cov qauv tov.Pipet 1 mL ntawm cov qauv tshuaj, ntxiv methanol ua raws nraim 100 mL, thiab siv cov tshuaj no raws li cov qauv kev daws teeb meem (1).Pipet 10 mL ntawm tus txheej txheem tov (1), ntxiv methanol kom raws nraim 20 mL, thiab siv cov tshuaj no raws li tus qauv tov (2).Ua qhov kev sim nrog cov kev daws teeb meem no raws li qhia hauv Thin-txheej Chromatography <2.03>.Spot 20 mL txhua tus qauv kev daws teeb meem thiab cov qauv kev daws teeb meem (1) thiab (2) ntawm lub phaj ntawm silica gel nrog fluorescent qhia rau nyias-txheej chromatography, tsim lub phaj nrog sib tov ntawm chloroform, methanol thiab acetic acid (100) ( 79:14:7) mus rau qhov deb li ntawm 15 cm, thiab cua qhuav lub phaj.Tshuaj xyuas nyob rau hauv lub teeb ultraviolet (lub ntsiab wavelength: 254 nm): cov chaw uas tsis yog lub hauv paus chaw thiab qhov chaw ntawm qhov qub tau los ntawm cov qauv tshuaj tsis yog khaus ntau dua li qhov chaw tau los ntawm cov txheej txheem daws teeb meem (1), thiab tag nrho cov nyiaj. ntawm cov chaw no los ntawm cov qauv kev daws teeb meem tsis ntau tshaj 2.0%.
Poob ntawm ziab <2.41> Tsis ntau tshaj 0.5% (1 g, 105 ℃, 3 teev).
Residue ntawm ignition <2.44> Tsis ntau tshaj 0.1% (1 g).
Assay Weigh kom raug tus nqi ntawm Chloramphenicol thiab Chloramphenicol RS, sib npaug li 0.1 g (potency), dissolve txhua hauv 20 mL ntawm methanol, thiab ntxiv dej kom raws nraim 100 mL.Pipet 20 mL txhua qhov kev daws teeb meem no, thiab ntxiv dej kom ua tiav 100 mL.Pipet 10 mL txhua qhov kev daws teeb meem no, ntxiv dej los ua kom tiav 100 mL, thiab siv cov kev daws teeb meem no raws li cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem.Txiav txim siab cov absorbances, AT thiab AS, ntawm 278 nm ntawm cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem raws li qhia hauv Ultraviolet-pom Spectrophotometry <2.24>.
Tus nqi [mg (potency)] ntawm chloramphenicol (C11H12Cl2N2O5)
＝ MS × AT/AS × 1000
MS: Tus nqi [mg (potency)] ntawm Chloramphenicol RS
coj
Containers thiab cia Containers-Tight containers.
Risk Codes R45 - Tej zaum yuav ua rau mob qog noj ntshav
R11 - Cov nplaim hluav taws kub heev
R39/23/24/25 -
R23/24/25 - Toxic los ntawm kev nqus pa, tiv tauj nrog daim tawv nqaij thiab yog tias nqos.
Kev Nyab Xeeb Kev Nyab Xeeb S53 - Tsis txhob raug - tau txais cov lus qhia tshwj xeeb ua ntej siv.
S45 - Thaum muaj xwm txheej lossis yog tias koj tsis xis nyob, nrhiav kev kho mob tam sim ntawd (qhia daim ntawv lo thaum twg los tau.)
S16 - Khaws kom deb ntawm qhov chaw hluav taws xob.
S36/37 - Hnav cov khaub ncaws tiv thaiv thiab hnab looj tes tsim nyog.
UN IDs 2811
WGK Germany 3
RTECS AB 6825000
FLUKA BRAND F CODE 3-10
TSCA Yes
HS Code 2941400000
Hazard Class 3
Toxicity LD50 qhov ncauj hauv nas: 2500mg / kg
P501: Pov tseg cov ntsiab lus / ntim rau hauv qhov chaw pov tseg pov tseg uas pom zoo.
P260: Tsis txhob ua pa plua plav / fume / gas / pos huab / vapors / tshuaj tsuag.
P270: Tsis txhob noj, haus lossis haus luam yeeb thaum siv cov khoom no.
P202: Tsis txhob ua haujlwm kom txog thaum tag nrho cov kev tiv thaiv kev nyab xeeb tau nyeem thiab nkag siab.
P201: Tau txais cov lus qhia tshwj xeeb ua ntej siv.
P264: Ntxuav daim tawv nqaij kom huv si tom qab tuav.
P280: Hnav cov hnab looj tes tiv thaiv / tiv thaiv khaub ncaws / tiv thaiv qhov muag / tiv thaiv ntsej muag.
P308 + P313: Yog tias kis tau los yog muaj kev txhawj xeeb: Tau txais cov lus qhia kho mob / saib xyuas.
P405: Lub khw kaw.
Shanghai Ruifu Chemical Co., Ltd. yog lub chaw muag khoom ntawm Chloramphenicol (CAS: 56-75-7) nrog cov khoom zoo.Chloramphenicol yog ib qho dav-spectrum antibacterial tshuaj tua kab mob, uas yog thawj qhov kev xaiv rau kev kho mob typhoid thiab paratyphoid, thib ob, nws yog siv rau kev kho mob ntawm ntau yam kab mob los ntawm cov kab mob rhiab heev.Vim muaj kev phiv loj heev tam sim no siv tsawg thiab tsawg.Cov tshuaj tua kab mob, kev ua haujlwm thiab kev siv yog tib yam li chloramphenicol rau kev kho mob Salmonella Typhi, Shigella, Escherichia coli, influenza, Brucella, mob ntsws los ntawm cocci thiab lwm yam tshuaj tua kab mob los tiv thaiv kab mob.Chloramphenicol feem ntau yog siv los kho cov kab mob urinary, Pneumonia, kab mob plab thiab septicemia tshwm sim los ntawm cov kab mob rhiab heev, nrog rau sab nraud qhov muag tee thiab pob ntseg tee.
UN3249 Tshuaj, khoom, tshuaj lom, nos, Hazard Class: 6.1;Cov ntawv lo: 6.1- Cov ntaub ntawv muaj kuab lom.UN2811 Toxic solids, organic, nos, Hazard Class: 6.1;Cov ntawv lo: 6.1- Cov ntaub ntawv muaj kuab lom, Kev Siv Lub Npe Yuav Tsum Tau.
