Crizotinib CAS 877399-52-5 Assay ≥99.0% API Hoobkas Zoo
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm Crizotinib (CAS: 877399-52-5) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, kev pabcuam zoo heev, me me thiab ntau ntau muaj.Yuav Crizotinib,Please contact: alvin@ruifuchem.com
| Tshuaj npe | Crizotinib |
| Synonyms | Xalkori;PF-02341066;Crozotinib;Crizotinib Xalkori;3-[1-(2,6-Dichloro-3-Fluoro-phenyl)-ethoxy]-5-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine;(R)-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]-5-(1-Piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine |
| CAS Nr | 877399-52-5 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
| Molecular Formula | C21H22Cl2FN5O |
| Molecular Luj | 450.34 Nws |
| Melting Point | 192 ℃ |
| Qhov ntom | 1.47 ± 0.10 g / cm3 |
| Cia Kub | Chav ntsuas kub |
| Keeb kwm | Shanghai, Suav |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb rau Off-White Powder |
| Kev txheeb xyuas | Los ntawm IR, HPLC |
| Clarity of Solution | Raws li Standard |
| Poob rau ziab | ≤ 1.00% |
| Residue ntawm Ignition | ≤0.50% |
| Related Impurities | (los ntawm HPLC) |
| Ib leeg Impurity | ≤0.50% |
| Tag nrho cov impurities | ≤ 1.00% |
| Hnyav Hlau | ≤ 20ppm |
| Assay | ≥99.0% |
| Residual Solvents | Ua raws li Specification |
| Txee lub neej | 24 Lub Hlis |
| Test Standard | Enterprise Standard |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav (2 ~ 8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Kev Nyab Xeeb Kev Nyab Xeeb 24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag.
UN IDs UN 3077 9 / PGIII
WGK Germany 3
HS Code 2933990099
Hazard Class IRRITANT
Crizotinib (CAS 877399-52-5), (Crizotinib, Xalkori R), yog lub zog thiab xaiv ATP kev sib tw me me molecule inhibitor ntawm ALK thiab c-Met.Thaum Lub Yim Hli 2011, Tebchaws Asmeskas FDA pom zoo Crizotinib rau kev kho mob ntawm anaplastic lymphoma kinase (ALK) rov kho cov qog nqaij hlav tsis me me (NSCLC).Crizotinib yog dual ATP kev sib tw inhibitor ntawm tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) thiab ALK (cellular IC50 = 20 nM), ob qho tib si yog lub hom phiaj tseem ceeb rau kev kho mob qog noj ntshav.Thaum crizotinib tau sim rau kev xaiv piv rau lwm cov kinases nws tau pom tias muaj enzyme IC50's hauv 100-fold ntau ntawm c-MET rau 13 ntawm 120 kinases kuaj.Hauv kev soj ntsuam ntawm tes, crizotinib tau pom tias inhibit RON (recepteur d'origine nantais) kinase nrog 10-fold selectivity qhov rais tshaj c-MET.
Crizotinib (PF-02341066) Crizotinib yog ib qho muaj zog c-Met thiab ALK inhibitor, IC50 qhov tseem ceeb hauv kev soj ntsuam ntawm tes yog 11 nM thiab 24 nM, feem.Nws tseem yog ib qho muaj zog inhibitor ntawm ROS1 nrog tus nqi Ki tsawg dua 0.025 nM.Crizotinib tuaj yeem ua rau autophagy hauv ntau hom kab mob ntsws cancer ntawm tes los ntawm inhibiting txoj hauv kev STAT3.
Crizotinib yog ib qho muaj zog thiab xaiv dual inhibitor ntawm mesenchymal-epithelial kev hloov pauv (c-MET) kinase thiab anaplastic lymphoma kinase (ALK).Crizotinib yog ib qho tshuaj tiv thaiv kab mob.Thaum Lub Yim Hli 2011, Tebchaws Asmeskas FDA pom zoo crizotinib rau kev kho mob ntawm anaplastic lymphoma kinase (ALK) rov kho cov qog nqaij hlav tsis me me (NSCLC).
Crizotinib (Xalkori(R), Pfizer), pom zoo nyob rau hauv 2011, yog thawj pom zoo inhibitor tsom rau anaplastic lymphoma kinase (ALK).ROS protooncogene 1-encoded kinase (ROS1) ntawm tyrosine kinase insulin receptor class thiab MET proto-oncogene-encoded kinase ntawm hepatocyte growth factor receptor (HGFR) chav kawm yog lwm kinases tsom los ntawm crizotinib.Thaum pom zoo hauv 2011, crizotinib yog thawj zaug. tshuaj tshwj xeeb rau cov neeg mob NSCLC.Txawm li cas los xij, kev tiv thaiv rau crizotinib feem ntau tau pom nyob rau hauv kwv yees li 8 lub hlis tom qab thawj daim ntawv thov thiab ntau tshaj li ib nrab ntawm cov neeg mob crizotinib tau ntsib kev mob plab hnyuv.Hauv 2016, crizotinib tau pom zoo ntxiv rau ROS1-zoo NSCLC los ntawm FDA.
Crizotinib (Xalkori) yog lub qhov ncauj receptor tyrosine kinase inhibitor qhia rau kev kho mob ntawm cov neeg mob uas muaj mob qog noj ntshav siab lossis metastatic non-me me ntawm lub ntsws cancer (NSCLC).Cov kev mob tshwm sim feem ntau nrog kev siv Xalkori suav nrog kev ua pa sab saud, xeev siab, ntuav, mob plab, tsis qab los noj mov, insomnia, kiv taub hau, nkees nkees, raws plab, cem quav, tawm pob lossis khaus, mob khaub thuas (qhov ntswg, txham, mob caj pas), loog lossis tingling, los yog o ntawm koj txhais tes lossis ko taw.
