α-Cyclodextrin (α-CD) CAS 10016-20-3 Pharmaceutical Excipients
Ruifu Chemical yog cov chaw tsim khoom ntawm α-Cyclodextrin (α-CD) (CAS: 10016-20-3) nrog cov khoom zoo.Ruifu Chemical muab cov khoom siv tshuaj qib cyclodextrins, tshuaj excipients.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, me me thiab ntau ntau.Yuav α-Cyclodextrin,Please contact: alvin@ruifuchem.com
| Tshuaj npe | α-Cyclodextrin hmoov |
| Synonyms | α-CD;C;Alfadex;alpha-Dextrin;α-Dextrin;Cyclohexapentylose;Cavamax W6;Schardinger α-Dextrin;α-Schardinger Dextrin;Schardinger alpha-Dextrin;Cyclomaltohexaose;Cyclohexaamylose |
| Tshuag xwm txheej | Hauv Tshuag, Kev Lag Luam Ntau Lawm |
| CAS Nr | 10016-20-3 |
| Molecular Formula | C |
| Molecular Luj | g/mol |
| Melting Point | ≥278 ℃ (txog.) (lit.) |
| Boiling Point | ℃ |
| Flash Point | ℃ |
| Qhov ntom | |
| Refractive Index n20/D | 1 |
| rhiab heev | Hygroscopic.Huab cua Sensitive, Lub teeb rhiab heev, Moisture Sensitive |
| Dej Solubility | Soluble hauv dej |
| Solubility | Soluble hauv |
| Kev ruaj ntseg | ruaj khov.Hluav taws kub.Incompatible Nrog Muaj Zog Oxidizing Agents. |
| COA & MSDS | Muaj |
| Qauv dawb | Muaj |
| Keeb kwm | Shanghai, Suav |
| Qeb | Pharmaceutical Excipients;Khoom noj khoom haus additives |
| Hom | Ruifu Tshuaj |
| Cov khoom | Specifications | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb los yog Yuav luag Dawb Amorphous lossis Crystalline Hmoov | Ua raws |
| Solubility | Dawb Soluble hauv dej thiab hauv Propylene Glycol, Xyaum Insoluble hauv Ethanol thiab hauv Methylene Chloride | Ua raws |
| ldentification HPLC | Lub sijhawm khaws cia ntawm lub ncov loj ntawm cov qauv kev daws teeb meem sib raug rau cov qauv kev daws teeb meem. | Ua raws |
| Iodine Test Solution | Lub Yellow-Brown Precipitate yog tsim | Ua raws |
| Assay | 98.0% ~ 101.0% (Xam rau ntawm Kev Qhuab Qhia) | 100.0% |
| Kev sib hloov tshwj xeeb [a]20/D | +147.0° to +152.0°(C=1 in H2O) (Calcd. on Anh. Tshuaj) | +148.2 ° |
| Clarity & Xim ntawm Kev daws | 10mg / ml dej tshuaj yog ntshiab thiab tsis muaj xim | Ua raws |
| Limit of Light-absorbing Substances | 0.10 (230 nm ~ 350 nm) ≤ 0.05 (350 nm ~ 750 nm) | Ua raws |
| Kev txiav txim siab dej | ≤ 11.0% | 9.9% |
| Residue ntawm Ignition | ≤0.10% | 0.07% |
| Hnyav Hlau | ≤ 5ppm | <5 ppm |
| Arsenic ntsev (As) | ≤ 1.3ppm | <1.3ppm |
| Txo Qab Zib | ≤ 0.20% | 0.16% |
| Yam khoom muaj feem | ||
| Betadex Cyclodextrin hmoov | ≤ 0.25% | N/D |
| Gamma Cyclodextrin hmoov | ≤ 0.25% | N/D |
| Lwm Yam Tshuaj | ≤0.50% | N/D |
| pH | 5.0 ~ 8.0 | 6.2 |
| Microbiological Test | ||
| Tag nrho Aerobic Microbial suav | ≤1000cfu / g | 30 cfu/g |
| Tag Nrho Pwm & Poov xab suav | ≤ 50cfu / g | <50cfu/g |
| Escherichia Coli | Tsis muaj | Tsis muaj |
| Salmonella | Tsis muaj | Tsis muaj |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| Test Standard | USP41-NF36 | |
Pob:0.5kg / / hnab, 1kg / hnab, 2kg / hnab, 10kg / hnab, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav thiab zoo-ventilated warehouse kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.Incompatible nrog muaj zog oxidizing neeg sawv cev.
Shipping:Xa mus thoob ntiaj teb los ntawm huab cua, los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Hazard Symbols Xi - Irritant
Risk Codes R36 - Irritating rau qhov muag
R36/37/38 - Kab mob rau qhov muag, ua pa thiab tawv nqaij.
Kev Nyab Xeeb Kev Nyab Xeeb S26 - Nyob rau hauv rooj plaub ntawm qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
S36 - Hnav khaub ncaws tiv thaiv zoo.
WGK Germany 3
RTECS GU2292000
TSCA Yes
HS Code 3505100000
α-Cyclodextrin (α-CD) (CAS: 10016-20-3)yog ib qho tsis txo qis cyclic saccharide uas muaj rau cov piam thaj uas txuas los ntawm alpha-1.4 daim ntawv cog lus.Nws yog tsim los ntawm kev ua ntawm cyclodextrin glucosyl transferase ntawm hydrolysed starch syrups.Cov kab noj hniav ntawm alpha-Cyclodextrin tsawg dua beta-Cyclodextrin, yog li nws yog siv los tso cai tsim cov complexes nrog me me molecules.Cov qib solubility ntawm Alpha-Cyclodextrin hauv dej yog 14.5 g / 100ml @ 25 ° C, yog li qhov xwm txheej xav tau siab solubility ntawm cyclodextrin.
Alpha-cyclodextrin yog dav siv nyob rau hauv cov tshuaj, khoom noj khoom haus, tsw thiab tshuaj pleev ib ce.Alpha-cyclodextrin kuj tau siv dav hauv kev siv tshuaj tua kab thiab kho cov metabolization ntawm cov qoob loo thiab ua kom cov qoob loo ntau ntxiv.Tshwj xeeb tshaj yog cov cyclodextrin thiab nws ramification uas tsim los ntawm cov xyoo no, ib txhia ntawm lawv yog cov tseem ceeb solutizer, stablizer, tso tawm los yog cov ntaub ntawv pab ntawm cov tshuaj Entericcoated, ib co ntawm lawv yog cov khoom ntawm organic synthetical macromolecular khoom.
Khoom noj khoom haus qib Alpha cyclodextrin nrog 6 qab zib units muaj qhov tsawg tshaj plaws kab noj ntawm niam txiv cyclodextrins.Nws yog ib qho tseem ceeb rau solubilizing, stabilizing los yog xa me me molecules, xws li tsis tshua muaj molecular yuag, tsw los yog tshuaj tsw qab tebchaw.Food qib Alpha cyclodextrin yog ua tswvcuab rau cov zaub mov kev lag luam raws li ib tug tshiab soluble noj fiber ntau nrog convincing zog.
Cyclodextrin muaj ib lub qhov nyob rau hauv nruab nrab ntawm lub nplhaib qauv, thiab ib tug oxygen atom nyob rau hauv uas -CH- khi rau glucoside.Nws yog sulfur-aqueous, thiab pawg hydroxyl ntawm 2, 3 thiab 6 txoj haujlwm ntawm cov piam thaj yog hydrophilic.Nws tuaj yeem siv los ua kom lwm cov molecules rau hauv kev sib koom ua ke los ntawm lub zog van der Waals tsis muaj zog.Muaj ntau yam khoom siv tau los ntawm cyclodextrins, nrog rau cov pa roj carbon monoxide, halogens, dyes, fragrances, tshuaj, zaub mov, tshuaj tua kab thiab tshuaj tua kab.Tom qab encapsulation, nws stability, volatility, solubility thiab reactivity yog txhim kho.Cov nyhuv tshwj xeeb ntawm Cyclodextrin ua rau nws siv dav hauv cov khoom siv encapsulation.
1. Kev siv Cyclodextrin hauv kev lag luam kws tshuaj tuaj yeem tsim encapsulation (encapsulation) nrog cov tshuaj, uas tuaj yeem ua rau (1) Cov tshuaj tsis ruaj khov;(2) Deliquescence, adhesion los yog kua tshuaj hmoov hmoov;(3) Insoluble lossis insoluble tshuaj tuaj yeem yaj (solubilized), thiab lwm yam.
2. Siv hauv kev lag luam tshuaj tua kab cyclodextrin encapsulation stabilization, qee cov tshuaj tua kab tuaj yeem khaws cia thiab txhim kho cov tshuaj tua kab.
3. Kev siv hauv kev lag luam zaub mov cyclodextrin yog siv rau hauv kev lag luam khoom noj khoom haus, muaj cov teebmeem hauv qab no: (1) Kev tshem tawm thiab npog cov ntxhiab tsw tshwj xeeb;(2) Kev txhim kho thiab txhim kho cov qauv ntawm cov khoom noj khoom haus;(3) txo qis thiab tshem tawm ntawm iab saj;(4) Antioxidant nyhuv;(5) Preservation thiab optimization ntawm tsw.
4. Kev siv Cyclodextrin hauv kev lag luam tshuaj niaj hnub hauv kev tsim tshuaj pleev ib ce kuj tuaj yeem siv los ua emulsifier thiab kev txhim kho zoo.Nws kuj muaj deodorization (xws li ntxiv rau halitosis) thiab tshuaj tua kab mob, tuaj yeem siv rau tshuaj txhuam hniav, tshuaj txhuam hniav.
5. Lwm yam kev siv hauv kev tiv thaiv ib puag ncig tuaj yeem siv los ua tus neeg sawv cev kho cov dej phwj tuaj.Cov tshuaj aqueous ntawm Cyclodextrin yog siv los ntxuav cov roj tank, thiab cov kua khib nyiab tuaj yeem rov qab tau thiab kho kom tau cov roj roj.
6. Kev siv cyclodextrin nyob rau hauv chemistry Cyclodextrin yog ib qho tseem ceeb tshuaj reagent.Thaum nws yog tam sim no, qhov fluorescence siv ntawm fluorochrome yuav nce ntxiv, yog li nws tuaj yeem siv rau kev txheeb xyuas cov protein thiab cov amino acids.Nws tseem tuaj yeem siv los cais cov kab sib txuas ntev ntev, racemes, thiab lwm yam.
Tsis tas li ntawd, cov adsorbent ua los ntawm Cyclodextrin tuaj yeem siv rau chromatographic adsorption.
Muaj nuj nqi
1. α-Cyclodextrin Ua kom muaj kev ruaj ntseg ntawm cov khoom: Tiv thaiv volatilization, tiv thaiv sublimation;Anti-oxidation;Tiv thaiv optothermal decomposition;Anti chemical decomposition;Nthuav lub sij hawm ntawm validity ntawm cov khoom.
2. α-Cyclodextrin Ua kom cov khoom solubility thiab bioavailability.
3. α-Cyclodextrin los ntawm kev tsim cov inclusion complex kom ua tau zoo npog excitant tsw.
4. α-Cyclodextrin Liquid tshuaj rau hauv lub xeev khov.
5. α-Cyclodextrin Tiv thaiv cov tshuaj - tshuaj, tshuaj - kev sib cuam tshuam ntawm cov tshuaj ntxiv.
6. α-Cyclodextrin Txo cov kev mob tshwm sim.
Daim ntawv thov
1. α-Cyclodextrin yog siv los ua kom ruaj khov ntawm cov khoom siv: Tiv thaiv volatilization, tiv thaiv sublimation;Anti-oxidation;
2. α-Cyclodextrin yog siv los tiv thaiv optothermal decomposition;Anti chemical decomposition;Nthuav lub sij hawm ntawm validity ntawm cov khoom.
3. α-Cyclodextrin yog siv los ua kom cov khoom solubility thiab bioavailability.
4. Los ntawm kev tsim cov inclusion complex kom ua tau zoo npog excitant tsw.Cov tshuaj ua kua rau hauv lub xeev khov.
5. α-Cyclodextrin yog siv los tiv thaiv cov tshuaj - tshuaj, tshuaj - kev sib cuam tshuam ntawm cov tshuaj ntxiv.
6. α-Cyclodextrin yog siv los txo cov kev mob tshwm sim.
Pharmaceutical:
1. Ua kom cov solubility ntawm lom muaj nyob
2. Txhawm rau txhim kho bioavailability
3. Kho lossis tswj qhov tso tawm
4. Txo cov tshuaj toxicity
5. Txhim kho qhov ruaj khov
Tshuaj pleev ib ce:
1. Kom haum rau encapsulation ntawm volatile tebchaw.
2. Ua kom lub neej txee ntawm cov khoom kim heev.
Khoom noj khoom haus:
1. Los tiv thaiv evaporation ntawm cov khoom volatile.
2. Kom tshem tau cov ntxhiab tsw phem.
3.Txhim kho cov teebmeem ntawm emulsification
α-Cyclodextrin tau pom los ua ib qho chaw ruaj khov nrog cov rog noj.Li no nws txo cov bioavailability thiab nqus cov rog.Nws paub tias tswj cov qib triglyceride thiab leptin hauv cov ntshav.Hauv cov qauv nas, α-Cyclodextrin tau pom tias ua rau cov tshuaj insulin rhiab heev thiab fecal fat excretion.Yog li, α-Cyclodextrin tau pom zoo rau kev kho mob rog rog thiab metabolic syndromes.
Muaj nyob rau hauv FDA Inactive Ingredients Database: α-Cyclodextrin (kev npaj txhaj tshuaj);β-Cyclodextrin (cov ntsiav tshuaj ntawm qhov ncauj, tshuaj pleev gels);γ-Cyclodextrin (IV txhaj).Muaj nyob rau hauv Canadian Daim Ntawv Teev Npe ntawm Cov Khoom Siv Tsis Siv Tshuaj (stabilizing agent; solubilizing agent);thiab nyob rau hauv qhov ncauj thiab qhov quav tshuaj formulations muaj ntawv tso cai nyob rau hauv cov teb chaws Europe, Nyiv, thiab lub teb chaws USA.
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