D-(+)-Cycloserine CAS 68-41-7 Assay ≥ 900μg/mg Hoobkas High Quality
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm D-(+)-Cycloserine (CAS: 68-41-7) nrog cov khoom zoo.Ruifu Chemical tuaj yeem muab kev xa khoom thoob ntiaj teb, tus nqi sib tw, me me thiab ntau ntau muaj.Yuav D-(+)-Cycloserine,Please contact: alvin@ruifuchem.com
| Tshuaj npe | D-(+)-Cycloserine |
| Synonyms | D-Cycloserine;(+) - Cycloserine;(R)-(+)-Cycloserine;(R)-(+)-4-Amino-3-Isoxazolidinone;Orientomycin;Oxamycin;α-Cycloserine |
| Tshuag xwm txheej | Hauv Tshuag |
| CAS Nr | 68-41-7 : kuv |
| Molecular Formula | C3H6N2O2 |
| Molecular Luj | 102.09 g / mol |
| Melting Point | 137 ℃ |
| rhiab heev | Cua Sensitive, Thaum tshav kub kub Sensitive |
| Solubility | Soluble hauv dej.Soluble me ntsis hauv Methanol thiab propylene Glycol.Insoluble hauv Chloroform thiab Ether. |
| Cia Temp. | Qhov chaw txias & qhuav (2 ~ 8 ℃) |
| COA & MSDS | Muaj |
| Hom | Ruifu Tshuaj |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb los yog daj daj daj crystalline hmoov | Ua raws |
| Kev sib hloov tshwj xeeb [α]20/D | +108.0° to +114.0° (C = 5, 2N NaOH) | +111.9 ° |
| Kev txheeb xyuas | Ib Xim Xim Xim maj mam tsim | Xim xiav |
| Condensation khoom | ≤0.80% (ntawm 286nm) | 0.08% |
| Poob rau ziab | <1.00% | 0.38% |
| Residue ntawm Ignition | <0.50% | 0.10% |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Volatile impurity | ||
| - Methanol | ≤ 500ppm | <500ppm |
| - Acetone | ≤ 500ppm | <500ppm |
| Assay (Antibiotics-Microbial Assays) | ≥900 μg / mg | 938g/mg 3 |
| pH | 5.5 rau 6.5 | 5.98 ib |
| FTIR | Ua raws | Ua raws |
| IR Spectrum | Ua raws | Ua raws |
| NMR Spectrum | Ua raws | Ua raws |
| Xaus | Cov khoom no los ntawm kev soj ntsuam raws li tus qauv USP-35 | |
Cycloserine [68-41-7].
Cycloserine muaj lub zog tsis pub tsawg dua 900μg ntawm C3H6N2O2 ib mg.
Ntim thiab khaws cia-Txuag hauv cov thawv nruj.
USP Reference cov qauv <11>-
USP Cycloserine RS
Kev txheeb xyuas-Dissolve txog 1 mg hauv 10 mL ntawm 0.1 N sodium hydroxide.Rau 1 mL ntawm cov kev daws teeb meem ntxiv 3 mL ntawm 1 N acetic acid thiab 1 mL ntawm kev sib tov, npaj 1 teev ua ntej siv, ntawm qhov sib npaug ntawm sodium nitroprusside tov (1 hauv 25) thiab 4 N sodium hydroxide: xim xiav maj mam. txhim kho.
Condensation khoom-Nws absorptivity (saib Spectrophotometric thiab Light-Scattering <851>) ntawm 285 nm, txiav txim siab hauv 0.1 N sodium hydroxide tov uas muaj 0.40 mg ib mL tsis ntau tshaj 0.80.
Kev sib hloov tshwj xeeb <781S>: ntawm 108 ° thiab 114 °.Kev ntsuas tshuaj: 50 mg ib mL, hauv 2 N sodium hydroxide.
Crystallinity <695>: ua tau raws li qhov yuav tsum tau ua
pH <791>: nruab nrab ntawm 5.5 thiab 6.5, hauv kev daws (1 ntawm 10).
Poob ntawm ziab <731>-Sry txog 100 mg hauv lub raj mis capillar y-stoppered hauv lub tshuab nqus tsev ntawm 60 ℃ rau 3 teev: nws poob tsis ntau tshaj 1.0% ntawm nws qhov hnyav.
Residue ntawm ignition <281>: tsis ntau tshaj 0.5%, cov charred residue tau moistened nrog 2 mL ntawm nitric acid thiab 5 tee ntawm sulfuric acid.
Assay-
pH 6.8 Phosphate buffer-Npaj raws li qhia nyob rau hauv Buffer Solutions nyob rau hauv cov kev daws teeb meem nyob rau hauv seem Reagents, Indicators, thiab Solutions.
Txawb theem-Dissolve 0.5 g ntawm sodium 1-decanesulfonate hauv 800 mL dej, ntxiv 50 mL ntawm acetonitrile thiab 5 mL ntawm glacial acetic acid, thiab sib tov.Kho nrog 1 N sodium hydroxide rau pH ntawm 4.4.Lim, thiab degas.Ua kev hloov kho yog tias tsim nyog y (saib System Suitability hauv Chromatography <621>).
Cov txheej txheem kev npaj-Quantitatively yaj ib qhov hnyav hnyav ntawm USP Cycloserine RS nyob rau hauv pH 6.8 Phosphate buffer kom tau txais cov tshuaj uas muaj ib tug paub concentration ntawm txog 0.4 mg ib mL.
Kev tshuaj ntsuam xyuas-Hloov txog 20 mg ntawm Cycloserine, ntsuas kom raug, mus rau 50-mL ntim ntim, yaj hauv thiab dilute nrog pH 6.8 Phosphate tsis rau ntim, thiab sib tov.
Chromatographic system (saib Chromatography <621>)-Cov kua chromatograph yog nruab nrog 219-nm detector thiab 4.6-mm × 25-cm kem uas muaj 5- µm packing L1.Tus nqi ntws yog li 1 mL ib feeb.Qhov kub thiab txias yog khaws cia ntawm li 30 ° C.Chromatograph tus txheej txheem npaj, thiab sau cov lus teb ncov raws li qhia rau Cov Txheej Txheem: tailing factor tsis ntau tshaj 1.8;thiab tus txheeb ze tus qauv sib txawv rau kev txhaj tshuaj replicate tsis ntau tshaj 2.0%.
Cov txheej txheem-Kev txhaj tshuaj sib npaug sib npaug (kwv yees li 10 µL) ntawm Cov Txheej Txheem Kev Npaj thiab Kev Ntsuas Kev Ntsuas rau hauv cov chromatograph, sau cov chromatograms, thiab ntsuas cov lus teb ncov rau cycloserine.Xam qhov ntau, hauv µg, ntawm C3H6N2O2 hauv txhua mg ntawm Cycloserine coj los ntawm cov mis:
50,000 (C / W) (rU / rS)
nyob rau hauv uas C yog qhov concentration, nyob rau hauv mg ib mL, ntawm USP Cycloserine RS nyob rau hauv tus txheej txheem npaj;W yog qhov ntau, hauv mg, ntawm Cycloserine coj los npaj Assay npaj;thiab rU thiab rS yog cov lus teb siab tshaj plaws rau cycloserine tau los ntawm Assay npaj thiab Standard npaj, feem.
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov txias thiab qhuav (2 ~ 8 ℃) warehouse kom deb ntawm cov khoom tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Shipping:Xa mus thoob ntiaj teb los ntawm FedEx / DHL Express.Muab kev xa khoom sai thiab txhim khu kev qha.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
Hazard Symbols Xn - Ua phem
Risk Codes
R5 - Cua sov tuaj yeem ua rau tawg
R20 - Ua phem los ntawm kev nqus pa
Kev nyab xeeb piav qhia
S38 - Yog tias qhov cua tsis txaus, hnav cov khoom ua pa uas tsim nyog.
S36/37 - Hnav cov khaub ncaws tiv thaiv thiab hnab looj tes tsim nyog.
S24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag.
WGK Germany 2
RTECS NY 2975000
FLUKA BRAND F CODE 10-23
HS Code 2941909099
D-(+)-Cycloserine (CAS: 68-41-7) muaj zog hygroscopic xwm, nws yog soluble nyob rau hauv dej, me ntsis soluble nyob rau hauv qis cawv, acetone thiab dioxane, thiab hardly soluble nyob rau hauv chloroform thiab petroleum ether.Nws yog ib qho ruaj khov nyob rau hauv alkaline tov thiab decomposes sai nyob rau hauv acidic los yog nruab nrab daws.Raws li ib tug dav-spectrum tshuaj tua kab mob, cycloserine yog inhibitive tawm tsam feem ntau Gram-positive thiab Gram-negative kab mob, rickettsia thiab ib co protozoa, tshwj tsis yog cov kab mob Mycobacterium tuberculosis., Nws kuj tseem siv tau rau qee cov kab mob Mycobacterium tuberculosis nrog kev ua siab ntev rau streptomycin, vinactane para-aminosalicylic acid, isoniazid thiab pyrazinamide.Cycloserine me ntsis synergizes nrog isoniazid nyob rau hauv inhibition ntawm Mycobacterium tuberculosis H37RV, tab sis nws tsis synergizes los yog antagonizes tawm tsam streptomycin.Cov khoom yog ib tug bacteriostatic tus neeg sawv cev, thiab yog li yuav tsis siv bactericidal nyhuv txawm tias thaum nce koob los yog ncua sij hawm ua hauj lwm nrog cov kab mob.
Lub Mechanism ntawm D-cycloserine cov tshuaj tua kab mob yog los inhibit biosynthesis ntawm peptidoglycan ntawm phab ntsa ntawm tes.Raws li nws yog cov qauv analogue ntawm D-alanine, D-cycloserine tuaj yeem cuam tshuam cov kev ua ub no ntawm alanine racemase thiab D-alanyl-D-alanine synthetase, uas yog ob qho tseem ceeb enzymes hauv peptidoglycan synthesis.D-cycloserine qhia tsis muaj zog tiv thaiv kev tiv thaiv Mycobacterium tuberculosis uas tsuas yog 1/10 txog 1/20 ntawm streptomycin.Qhov zoo ntawm cov khoom yog tias nws muaj txiaj ntsig zoo ntawm cov tshuaj tiv thaiv kab mob Mycobacterium tuberculosis thiab tsis tshua muaj peev xwm ua rau cov tshuaj tiv thaiv.Cov khoom siv tuaj yeem siv nrog lwm cov tshuaj tiv thaiv kab mob hauv kev kho mob tuberculosis los ntawm cov tshuaj tiv thaiv Mycobacterium tuberculosis.
Cycloserine yog ib hom tshuaj tiv thaiv tuberculosis thib ob.Nws tuaj yeem cuam tshuam kev loj hlob ntawm Mycobacterium tuberculosis, tab sis cov nyhuv yog qhov tsis muaj zog dua li cov tshuaj thawj kab.Nws txoj kev ua tau zoo hauv kev kho tuberculosis yog qhov tsawg.Kev siv tshuaj ib leeg tuaj yeem tsim cov tshuaj tiv thaiv, tab sis qhov kev tiv thaiv tshwm sim maj mam piv nrog rau lwm cov tshuaj tiv thaiv kab mob.Tsis muaj kev tiv thaiv kab mob sib kis ntawm cycloserine thiab lwm yam tshuaj tiv thaiv kab mob.Lub mechanism ntawm nws cov tshuaj tua kab mob yog inhibit qhov synthesis ntawm peptidoglycan ntawm cov kab mob ntawm cov phab ntsa ntawm tes, ua rau muaj kev puas tsuaj hauv cell phab ntsa architecture.Cov txheej txheem tseem ceeb ntawm cov phab ntsa ntawm cov kab mob yog peptidoglycan, uas yog tsim los ntawm N-acetylglucosamine (GNAc) thiab N-acetylmuramic acid (MNAc).N-acetylmuramic acid txuas nrog pentapeptide thiab txuas N-acetylglucosamine nyob rau hauv ib qho reduplicated thiab lwm yam.Kev tsim ntawm cytoplasmic peptidoglycan precursor tuaj yeem cuam tshuam los ntawm cycloserine, vim tias tom kawg tuaj yeem cuam tshuam cov racemase thiab cov synthetase ntawm D-Alanine, thiab yog li thaiv kev tsim N-acetylmuramic acid.
D-Cycloserine tuaj yeem tau los ntawm cov txheej txheem fermentation lossis los ntawm kev sib txuas ncaj qha.Cov kab mob uas siv hauv fermentation yog Actinomyces laven-dulae.Qhov nruab nrab fermentation muaj dextrin, dextrose, starch, soybean hmoov, poov xab hmoov, ammonium sulfate, ammonium nitrate, calcium carbonate, sodium chloride, magnesium sulfate thiab soybean roj.Hauv cov txheej txheem synthesis, D-Cycloserine tau txais los ntawm β-Aminooxy alanine ethyl ester hydrochloride los ntawm cov tshuaj tiv thaiv nrog potassium hydroxide hauv cov tshuaj tiv thaiv cyclization.
