DAPT (GSI-IX) CAS 208255-80-5 γ-Secretase Inhibitor Assay > 98.0% (HPLC) Hoobkas
Shanghai Ruifu Chemical Co., Ltd. yog cov chaw tsim khoom ntawm DAPT (GSI-IX) (CAS: 208255-80-5) nrog cov khoom zoo, γ-Secretase Inhibitor.Ruifu Chemical muab ntau cov amino acids thiab derivatives.Peb tuaj yeem muab kev xa khoom thoob ntiaj teb, me me thiab ntau qhov ntau.Muas DAPT,Please contact: alvin@ruifuchem.com
| Tshuaj npe | DAPT |
| Synonyms | GSI-IX;γ-Secretase Inhibitor IX;gamma-Secretase Inhibitor;LY-374973;(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu;(3,5-Difluorophenylacetyl)-L-Alanyl-L-2-Phenylglycine tert-Butyl Ester;N-[N-(3,5-Difluorophenacetyl)-L-Alanyl]-S-Phenylglycine t-Butyl Ester;(2S)-N-[2-(3,5-Difluorophenyl)acetyl]-L-Alanyl-2-Phenyl-glycine 1,1-Dimethylethyl Ester |
| Tshuag xwm txheej | Hauv Tshuag |
| CAS Nr | 208255-80-5 |
| Molecular Formula | C23H26F2N2O4 |
| Molecular Luj | 432.47 ib |
| Qhov ntom | 1.213 g / cm3 |
| Melting Point | 142.0 ~ 146.0 ℃ |
| rhiab heev | Thaum tshav kub kub Sensitive |
| Solubility | Soluble hauv DMSO |
| Cia Temp. | Khaws ntawm 2-8 ℃ |
| COA & MSDS | Muaj |
| Hom | Ruifu Tshuaj |
| Cov lus hais txog kev nyab xeeb | 24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag. | ||
| WGK Germany | 3 | HS Code | 2922491990 ib |
| Cov khoom | Kev soj ntsuam Standards | Cov txiaj ntsig |
| Qhov tshwm sim | Dawb los yog Off-White Crystalline Hmoov | Ua raws |
| Poob rau ziab | <0.40% | 0.21% |
| Residue ntawm Ignition | <0.40% | 0.20% |
| Heavy Metals (raws li Pb) | ≤ 20ppm | <20 ppm |
| Assay / Analysis Method | > 98.0% (HPLC) | 98.62% |
| Carbon los ntawm Elemental Analysis | 62.1 ~ 64.1% | Ua raws |
| Nitrogen los ntawm Elemental Analysis | 6.20 ~ 6.70% | Ua raws |
| Infrared Spectrum | Raws li tus qauv | Ua raws |
| NMR Spectrum | Raws li tus qauv | Ua raws |
| Xaus | Cov khoom no los ntawm Kev Tshawb Fawb Pom Zoo nrog Cov Txheej Txheem Enterprise | |
| Txee lub neej | 24 lub hlis txij hnub tsim khoom yog tias khaws cia kom raug | |
Pob: Fluorinated Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, lossis raws li cov neeg siv khoom xav tau.
Cia txias:Khaws rau hauv cov thawv ntim kaw ntawm qhov txias, qhuav (kho ntawm 2-8 ℃) thiab lub tsev tso cua txias kom deb ntawm cov khoom siv tsis sib xws.Tiv thaiv los ntawm lub teeb thiab noo noo.
Yuav Yuav Li Cas?Thov hu rauDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Xyoo Kev Paub?Peb muaj ntau tshaj li 15 xyoo ntawm kev paub nyob rau hauv kev tsim thiab export ntawm ib tug ntau yam ntawm zoo tshuaj intermediates los yog zoo tshuaj.
Kev lag luam loj?Muag rau kev lag luam hauv tsev, North America, Europe, India, Kauslim, Nyiv, Australia, thiab lwm yam.
Qhov zoo?Superior zoo, tus nqi pheej yig, kev pabcuam tshaj lij thiab kev txhawb nqa kev pabcuam, xa khoom sai.
ZooKev lees paub?Kev tswj xyuas nruj nruj.Cov cuab yeej tshaj lij rau kev txheeb xyuas suav nrog NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, thiab lwm yam.
Cov qauv?Cov khoom lag luam feem ntau muab cov qauv dawb rau kev soj ntsuam zoo, tus nqi thauj khoom yuav tsum tau them los ntawm cov neeg siv khoom.
Factory Audit?Lub Hoobkas tshawb xyuas txais tos.Thov teem caij ua ntej.
MOQ?Tsis muaj MOQ.Kev txiav txim me me tau txais.
Lub sij hawm xa tuaj? Yog hais tias nyob rau hauv Tshuag, peb hnub shipping guaranteed.
Kev thauj mus los?Los ntawm Express (FedEx, DHL), los ntawm Cua, los ntawm hiav txwv.
Cov ntaub ntawv?Kev pab cuam tom qab muag: COA, MOA, ROS, MSDS, thiab lwm yam tuaj yeem muab tau.
Kev cai Synthesis?tuaj yeem muab cov kev pabcuam sib xyaw ua ke kom haum rau koj cov kev xav tau tshawb fawb.
Cov nqe lus them nqi?Proforma invoice yuav raug xa ua ntej tom qab kev pom zoo ntawm kev txiav txim, kaw peb cov ntaub ntawv hauv tuam txhab nyiaj.Kev Them Nyiaj los ntawm T / T (Telex Transfer), PayPal, Western Union, thiab lwm yam.
DAPT (GSI-IX) (CAS: 208255-80-5), muaj zog thiab tshwj xeeb inhibitor ntawm γ-secretase.DAPT yog ib qho inhibitor ntawm γ-secretase (IC50 hauv tib neeg thawj neurons = 115 nM rau tag nrho Aβ lossis 200 nM rau Aβ42 tshwj xeeb).Kev tswj hwm qhov ncauj ntawm DAPT tau pom tias txo qis Aβ hauv lub hlwb extract, cerebrospinal kua thiab ntshav los ntawm cov nas thiab nas.DAPT blocks Notch signaling uas txhawb nqa neuronal sib txawv ntawm cov hlwb ua ntej.Txhim kho iPS hlwb tsis muaj oncogenes KLF4 thiab CMYC5.Cell permeable.DAPT yog siv rau hauv kev tshawb fawb ntawm β-amyloid tsim.DAPT tau pom tias inhibit Notch signaling nyob rau hauv kev tshawb fawb ntawm autoimmune thiab lymphoproliferative kab mob, xws li ALPS thiab lupus erythematosus, nrog rau cov qog nqaij hlav cancer, angiogenesis, thiab sib txawv ntawm tib neeg induced pluripotent qia hlwb.Inhibits Notch signaling hauv vitro.Inhibits tag nrho Aβ thiab Aβ42 ntau lawm hauv tib neeg cov kab lis kev cai (IC50 qhov tseem ceeb yog 115 thiab 200 nM, feem) uas tsis cuam tshuam rau APPα thiab APPβ theem.Ntshav-hlwb barrier permeable.3D Loj hlob matrix tivthaiv thiab cov khoom ntawm cerebral organoid sib txawv xov xwm.
