Daptomycin CAS 103060-53-3 Purity ≥95.0% API Hoobkas High Purity

Daptomycin (CAS: 103060-53-3) yog ib hom tshuaj tua kab mob cyclic lipopeptide nrog cov qauv tshiab.Nws yog muab rho tawm los ntawm Streptomyces fermentation broth.Nws tau tshawb pom los ntawm Eli Lilly Tuam Txhab hauv xyoo 1980s, thiab tau tsim tiav hauv xyoo 1997 los ntawm Cubist Pharmaceuticals.Nws tsis tsuas yog muaj cov qauv tshuaj tshiab tab sis kuj muaj hom kev ua uas txawv ntawm cov tshuaj tua kab mob uas tau pom zoo ua ntej: nws inhibits cell los ntawm kev cuam tshuam kev thauj cov amino acids los ntawm cov cell membrane, yog li thaiv cov phab ntsa ntawm tes peptidoglycan biosynthesis thiab hloov qhov xwm txheej ntawm lub cell. cell membrane.Nws tuaj yeem rhuav tshem cov kab mob cell membrane ua haujlwm hauv ntau yam, thiab tua cov kab mob gram-zoo sai.Ntxiv rau lub luag haujlwm ntawm kev noj cov tshuaj feem ntau cuam tshuam rau cov kab mob gram-zoo, qhov tseem ceeb tshaj, Daptomycin muaj cov txiaj ntsig zoo hauv kev kho cov kab mob sib cais uas tau pom cov tsos mob ntawm kev tiv thaiv methicillin, vancomycin thiab linezolid.Cov cuab yeej no tseem ceeb heev rau cov neeg mob uas muaj mob hnyav.Thaum lub Cuaj Hlis 2003, US Food and Drug Administration tau pom zoo thawj zaug tias Daptomycin (CAS: 103060-53-3) tuaj yeem siv rau kev kho mob ntawm daim tawv nqaij mob hnyav.Thaum Lub Peb Hlis 2006, nws tau pom zoo los kho cov kab mob sib kis.Thaum Lub Ib Hlis Ntuj xyoo 2006, nws tau pom zoo los ntawm European Commission rau kev kho mob ntawm qee yam tawv nqaij thiab cov nqaij mos kab mob los ntawm kab mob gram-zoo.Thaum lub Cuaj Hlis 6, 2007, Cubist Pharmaceuticals tshaj tawm tias European Union tau pom zoo nws cov tshuaj tua kab mob, Cubicin rau kev kho mob ntawm lub plawv endocarditis tshwm sim los ntawm Staphylococcus aureus kab mob thiab cov tawv nqaij tawv thiab cov nqaij mos kab mob cuam tshuam los ntawm Staphylococcus aureus.