Darunavir Ethanolate CAS 635728-49-3 Purity ≥99.0% API Hoobkas Anti-HIV HIV Protease Inhibitor
Chaw tsim tshuaj paus Supply Darunavir Yam khoom:
Darunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
(3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone CAS 102123-74-0
| Tshuaj npe | Darunavir Ethanolate |
| Synonyms | DRV;Prezista;TMC114 Ethanolate;UNII-33O78XF0BW;N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro [2,3-b]furan-3-yl ester compd.nrog ethanol |
| CAS Nr | 635728-49-3 |
| CAT Number | Tus Qauv Zauv: RF-API69 |
| Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
| Molecular Formula | C29H43N3O8S |
| Molecular Luj | 593.73 ib |
| Hom | Ruifu Tshuaj |
| Yam khoom | Specifications |
| Qhov tshwm sim | Dawb los yog Off-White Crystalline Hmoov |
| Identification IR | Raws li Standard Spectrum |
| Kev sib hloov tshwj xeeb | -0.5° ~ + 0.5° |
| Yam khoom muaj feem | (los ntawm HPLC) |
| Max ib leeg impurity | ≤ 0.20% |
| Tag nrho cov impurities | ≤0.50% |
| Dej (KF) | ≤ 1.0% |
| Residue ntawm Ignition | ≤0.10% |
| Hnyav Hlau | ≤10ppm |
| Cov ntsiab lus ntawm Ethanol | ≤7.5% (GC) |
| Residual Solvents | Methanol ≤0.30% |
| Purity | ≥99.0% (HPLC) |
| Test Standard | Enterprise Standard |
| Kev siv | Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard Nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
Darunavir Ethanolate (Prezista) yog tus kab mob HIV protease inhibitor.Derivative ntawm Darunavir, thib ob tiam HIV-1-protease inhibitor;structurally zoo ib yam li amprenavir.Antiviral.Nws yog cov khoom tshawb fawb txog COVID19.Hmoov tsis zoo, DRV muaj cov solubility tsawg hauv dej thiab tsis muaj bioavailability, yog li nws xav tau kev tswj hwm hauv cov koob tshuaj ntau heev txhawm rau ua kom pom kev kho tau zoo.Darunavir yog ib tug broad-spectrum potent inhibitor active tiv thaiv HIV-1 chaw kho mob cais nrog tsawg cytotoxicity.Darunavir tsim hydrogen daim ntawv cog lus nrog kev txuag lub ntsiab-chain atoms ntawm Asp29 thiab Asp30 ntawm protease.Cov kev sib cuam tshuam no tau npaj los ua qhov tseem ceeb rau lub zog ntawm qhov sib xyaw no tiv thaiv kab mob HIV uas tiv taus ntau yam protease inhibitors.Hauv kev tshawb fawb hauv vitro hauv MT-2 hlwb, lub zog ntawm darunavir yog ntau dua li ntawm saquinavir, amprenavir, nelfinavir, indinavir, lopinavir thiab ritonavir.Darunavir feem ntau metabolized los ntawm hepatic cytochrome P450 (CYP) enzymes, feem ntau CYP3A.Cov koob tshuaj 'boosting' ntawm ritonavir ua ib qho inhibitor ntawm CYP3A, yog li ua rau darunavir bioavailability.Darunavir tau tsim los tsim kev sib cuam tshuam nrog cov enzyme protease los ntawm ntau hom kab mob HIV, suav nrog cov kab mob los ntawm kev kho mob-kev paub txog cov neeg mob uas muaj ntau yam tiv thaiv mutati.
