Desmopressin Acetate CAS 16789-98-3 Peptide Purity (HPLC) ≥98.5% Hoobkas

Hazard Symbols Xn - Ua phem
Risk Codes 20 - Ua phem los ntawm kev nqus pa
Safety Description 36 - Hnav cov khaub ncaws tiv thaiv kom haum.
WGK Germany 3

Desmopressin Acetate (CAS: 16789-98-3) uas yog, 1-cysteine ​​deamination thiab 8-D-arginine es tsis txhob 8-l-arginine, tseem hu ua arginine vasopressin, yog ib tug qauv analogue ntawm natural arginine vasopressin, ib tug derivative ntawm vasopressin, nws cov nyhuv antidiuretic muaj zog dua thiab kav ntev tshaj li vasopressin, tab sis tsis muaj vasoconstrictor nyhuv, tshuaj phiv tshuaj, kev kho mob rau lub hauv paus los yog cov tshuaj uas tshwm sim los ntawm platelet tsis ua haujlwm, uremia, daim siab mob siab thiab tsis paub tias yog vim li cas los ntawm lub sij hawm los ntshav ntev;tuaj yeem siv los tswj thiab tiv thaiv los ntshav thaum phais me me;Central ntshav qab zib insipidus.Hauv ib tus neeg mob, cov khoom no tseem yuav ua rau muaj txiaj ntsig zoo rau cov neeg mob uas muaj kab mob hauv cov kab mob urinary nruab nrab, feem ntau ua tsis taus rau cov neeg mob uas muaj tus kab mob IIB von Willebrand.
Pharmacological kev txiav txim: Desmopressin Acetate muaj desmopressin uas zoo ib yam li haiv neeg arginine vasopressin.Nws yog qhov sib txawv ntawm arginine vasopressin, feem ntau yog rau ib nrab ntawm cov amino acid thiab D arginine los hloov L Arginine.Cov kev hloov pauv ntawm cov qauv no ncua lub sijhawm ntawm kev ua haujlwm ntawm kev kho mob koob tshuaj desmopressin yam tsis muaj kev phiv los ntawm compression.Qee cov kev tshawb fawb tau pom tias cov nyhuv ntawm kev tiv thaiv enuresis yog qhov tseem ceeb, uas tej zaum yuav yog vim qhov nce ntawm arginine vasopressin qib hauv cov ntshav ntawm cov menyuam thaum hmo ntuj, thiab tom qab ntawd mloog cov zis, txo cov zis ntim thiab intravascular siab, txo caj dab thiab. detrusor contraction.
Nws txoj kev ua tau zoo, yooj yim ntawm kev tswj hwm (intranasal), lub sijhawm ntev ntawm kev ua haujlwm, thiab tsis muaj cov kev mob tshwm sim ua rau nws cov tshuaj xaiv rau kev kho mob hauv nruab nrab ntshav qab zib insipidus.Nws kuj tseem tuaj yeem muab tshuaj intramuscularly lossis intravenously.Nws yog qhov zoo dua rau kev txhaj tshuaj vasopressin thiab qhov ncauj antidiuretics siv rau cov menyuam yaus.Nws tau qhia txog kev tswj hwm ntawm ib ntus polydipsia thiab polyuria txuam nrog kev raug mob rau, lossis kev phais hauv, thaj tsam pituitary.
Kev siv tshuaj kho mob: Desmopressin, raws li nws cov ntsev acetate, yog ib qho hluavtaws analogue ntawm vasopressin nyob rau hauv uas N terminal Cys yog devoid ntawm nws α-amino muaj nuj nqi (1-Deamino) thiab qhov twg Arg8 yog tam sim no raws li nws D-isomer (D-Arg8) , yog li kev lag luam acronym DDAVP.Lub xub ntiag ntawm D-Arg thiab qhov tsis muaj N-terminal amine nyob rau hauv cov qauv desmopressin tau nce nws ib nrab-lub neej xws li nws muaj rau kev siv qhov ncauj, parenteral, lossis qhov ntswg.Nws yog siv los ntawm tag nrho peb txoj hauv kev ntawm kev tswj hwm los tiv thaiv lossis tswj polydipsia (nqus nqhis dej ntau), polyuria, thiab lub cev qhuav dej ntawm cov neeg mob ntshav qab zib insipidus los ntawm qhov tsis txaus ntawm vasopressin.Nws kuj tau txais kev pom zoo rau kev kho mob ntawm nocturnal enuresis (bed-wetting), uas ntseeg tau tias yog tshwm sim los ntawm qhov tsis muaj lub sijhawm hmo ntuj nce hauv vasopressin qib.Desmopressin paub tias ua rau muaj kev nce ntxiv hauv plasma factor VIII (antihemophilic factor) thiab plasminogen activator.Nws yog li ntawd tau pom zoo los ntawm US FDA rau kev siv, parenterally thiab nasally, hauv kev txo qhov tshwm sim los yog raug mob los ntshav hauv cov neeg mob hemophilia A thiab hom I Von Willebrand tus kab mob, muab tias lawv cov ntshav plasma VIII kev ua ntau dua 5%.Stimate, cov tshuaj tsuag qhov ntswg siv los kho cov neeg mob hemophilia A thiab hom I Von Willebrand tus kab mob, yog 15-fold qhov concentration ntawm DDAVP qhov ntswg tsuag;tom kawg yog siv los kho mob ntshav qab zib insipidus.