Entecavir Monohydrate CAS 209216-23-9 API Hoobkas High Quality Antiviral Hepatitis B Infection

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Lub npe tshuaj: Entecavir Monohydrate

CAS: 209216-23-9 Nr

Cov tsos mob: Dawb los yog yuav luag dawb crystalline hmoov

Tshuaj tua kab mob siv los kho kab mob siab B

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Product Detail

Yam khoom

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Lub npe tshuaj: Entecavir Monohydrate
CAS: 209216-23-9 Nr
Siv los kho kab mob siab B
API High Quality, Commercial Production

Chemical Properties:

Tshuaj npe	Entecavir Monohydrate
Synonyms	Entecavir Hydrate;9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine Monohydrate
CAS Nr	209216-23-9
CAT Number	RF-API 79
Tshuag xwm txheej	Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms
Molecular Formula	C12H17N5O4
Molecular Luj	295.3 ib
Melting Point	> 220 ℃
Qhov ntom	1.81 ib
Shipping Condition	Shipped nyob rau hauv ambient kub
Hom	Ruifu Tshuaj

Specifications:

Yam khoom	Specifications
Qhov tshwm sim	Dawb los yog Yuav luag Dawb Crystalline Hmoov
Solubility	Dawb Soluble hauv Dimethylformamide, Me ntsis Soluble hauv dej, Ethanol thiab Methanol
Identification IR	Spectrum ntawm tus qauv sib raug raws li tus qauv siv
Kev txheeb xyuas HPLC	Lub sijhawm khaws cia ntawm cov qauv xeem sib raug raws li tus qauv siv
Cov ntsiab lus dej (los ntawm KF)	5.5% ~ 6.5%
Specific Optical Rotation	+24.0 ° txog +30.0 ° (DMF: MeOH = 1: 1 C = 1%) (ntawm cov khoom tsis muaj dej)
Residue ntawm Ignition	≤0.10%
Yam khoom muaj feem
Furoentecavir	≤0.10%
Entecavir 1-Epimer	≤0.10%
Entecavir 3-Epimer	≤0.10%
8-Methyoxy Entecavir	≤0.10%
Entecavir 4-Epimer	≤0.10%
8-Hydroxy Entecavir	≤0.10%
4-Dimethylsilyl Entecavir	≤0.10%
Entecavir Related Compound A	≤0.10%
Tej yam tsis meej tsis meej	≤0.10%
Tag nrho cov impurities	≤ 0.30%
Residual Solvents
Methanol	≤600ppm
Dichloromethane	≤300ppm
Ethyl Acetate	≤1000ppm
Tetrahydrofuran	≤720ppm
Toluene	≤890ppm
Benzyl Chloride	≤1000ppm
Benzyl cawv	≤1000ppm
Microbial txwv
Tag nrho Aerobic suav	≤100cfu / g
Yeasts thiab Pwm	≤10cfu/g
Escherichia Coli	Yuav Tsis Pom
Hnyav Hlau	≤10ppm
Assay	98.0% ~ 102.0% (HPLC; ntawm lub hauv paus tsis muaj dej)
Particle Loj	95% ntawm cov khoom yuav tsum tsis pub dhau 125um
Test Standard	Enterprise Standard;Teb Chaws Asmeskas Pharmacopoeia (USP) Standard
Kev siv	Tshuaj tua kab mob siv los kho kab mob siab B

Pob & Cia:

Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.

Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.

Qhov zoo:

FAQ:

Daim ntawv thov:

Entecavir Monohydrate (CAS 209216-23-9) yog ib qho tshuaj tiv thaiv kab mob hauv qhov ncauj uas siv los kho tus kab mob siab B (HBV).Entecavir Monohydrate yog ib qho nucleoside analogue (tshwj xeeb tshaj yog, ib qho guanine analogue) uas inhibits kev thim rov qab, DNA replication thiab transcription hauv vira.Nws yog ib yam tshiab ntawm cyclopentyl acyl guanosine tshuaj tiv thaiv kab mob siab B nrog nws cov tshuaj pharmacological zoo ib yam li Entecavir.Nws yog siv rau kev kho mob ntawm cov neeg laus mob siab kab mob siab B nyob rau hauv uas muaj active viral replication, nce serum transaminase ALT los yog active lesions pom los ntawm daim siab histology.Entecavir Monohydrate yog ib qho muaj zog thiab xaiv inhibitor ntawm HBV, nrog EC50 ntawm 3.75 nM hauv HepG2 cell.Entecavir yog ib qho kev thim rov qab transcriptase inhibitor.Nws tiv thaiv tus kab mob siab B (HBV) los ntawm kev sib npaug thiab txo cov kab mob hauv lub cev.