Entecavir Monohydrate CAS 209216-23-9 API Hoobkas High Quality Antiviral Hepatitis B Infection
Chaw tsim tshuaj paus Supply nrog High Purity thiab ruaj khov zoo
Lub npe tshuaj: Entecavir Monohydrate
CAS: 209216-23-9 Nr
Siv los kho kab mob siab B
API High Quality, Commercial Production
Tshuaj npe | Entecavir Monohydrate |
Synonyms | Entecavir Hydrate;9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine Monohydrate |
CAS Nr | 209216-23-9 |
CAT Number | RF-API 79 |
Tshuag xwm txheej | Nyob rau hauv Tshuag, ntau lawm Scale nce mus txog pua pua ntawm Kilograms |
Molecular Formula | C12H17N5O4 |
Molecular Luj | 295.3 ib |
Melting Point | > 220 ℃ |
Qhov ntom | 1.81 ib |
Shipping Condition | Shipped nyob rau hauv ambient kub |
Hom | Ruifu Tshuaj |
Yam khoom | Specifications |
Qhov tshwm sim | Dawb los yog Yuav luag Dawb Crystalline Hmoov |
Solubility | Dawb Soluble hauv Dimethylformamide, Me ntsis Soluble hauv dej, Ethanol thiab Methanol |
Identification IR | Spectrum ntawm tus qauv sib raug raws li tus qauv siv |
Kev txheeb xyuas HPLC | Lub sijhawm khaws cia ntawm cov qauv xeem sib raug raws li tus qauv siv |
Cov ntsiab lus dej (los ntawm KF) | 5.5% ~ 6.5% |
Specific Optical Rotation | +24.0 ° txog +30.0 ° (DMF: MeOH = 1: 1 C = 1%) (ntawm cov khoom tsis muaj dej) |
Residue ntawm Ignition | ≤0.10% |
Yam khoom muaj feem | |
Furoentecavir | ≤0.10% |
Entecavir 1-Epimer | ≤0.10% |
Entecavir 3-Epimer | ≤0.10% |
8-Methyoxy Entecavir | ≤0.10% |
Entecavir 4-Epimer | ≤0.10% |
8-Hydroxy Entecavir | ≤0.10% |
4-Dimethylsilyl Entecavir | ≤0.10% |
Entecavir Related Compound A | ≤0.10% |
Tej yam tsis meej tsis meej | ≤0.10% |
Tag nrho cov impurities | ≤ 0.30% |
Residual Solvents | |
Methanol | ≤600ppm |
Dichloromethane | ≤300ppm |
Ethyl Acetate | ≤1000ppm |
Tetrahydrofuran | ≤720ppm |
Toluene | ≤890ppm |
Benzyl Chloride | ≤1000ppm |
Benzyl cawv | ≤1000ppm |
Microbial txwv | |
Tag nrho Aerobic suav | ≤100cfu / g |
Yeasts thiab Pwm | ≤10cfu/g |
Escherichia Coli | Yuav Tsis Pom |
Hnyav Hlau | ≤10ppm |
Assay | 98.0% ~ 102.0% (HPLC; ntawm lub hauv paus tsis muaj dej) |
Particle Loj | 95% ntawm cov khoom yuav tsum tsis pub dhau 125um |
Test Standard | Enterprise Standard;Teb Chaws Asmeskas Pharmacopoeia (USP) Standard |
Kev siv | Tshuaj tua kab mob siv los kho kab mob siab B |
Pob: Lub raj mis, Aluminium ntawv ci hnab, Cardboard nruas, 25kg / Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws rau hauv cov thawv ntim khoom ntawm qhov chaw txias thiab qhuav;Tiv thaiv los ntawm lub teeb, noo noo thiab kab tsuag.
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Entecavir Monohydrate (CAS 209216-23-9) yog ib qho tshuaj tiv thaiv kab mob hauv qhov ncauj uas siv los kho tus kab mob siab B (HBV).Entecavir Monohydrate yog ib qho nucleoside analogue (tshwj xeeb tshaj yog, ib qho guanine analogue) uas inhibits kev thim rov qab, DNA replication thiab transcription hauv vira.Nws yog ib yam tshiab ntawm cyclopentyl acyl guanosine tshuaj tiv thaiv kab mob siab B nrog nws cov tshuaj pharmacological zoo ib yam li Entecavir.Nws yog siv rau kev kho mob ntawm cov neeg laus mob siab kab mob siab B nyob rau hauv uas muaj active viral replication, nce serum transaminase ALT los yog active lesions pom los ntawm daim siab histology.Entecavir Monohydrate yog ib qho muaj zog thiab xaiv inhibitor ntawm HBV, nrog EC50 ntawm 3.75 nM hauv HepG2 cell.Entecavir yog ib qho kev thim rov qab transcriptase inhibitor.Nws tiv thaiv tus kab mob siab B (HBV) los ntawm kev sib npaug thiab txo cov kab mob hauv lub cev.
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