Flurbiprofen CAS 5104-49-4 Assay 99.0 ~ 100.5% (HPLC) Hoobkas

Flurbiprofen
C15H13FO2 244.27
(±)-2-(2-Fluoro-4-biphenylyl)propionic acid [5104-49-4].
Flurbiprofen muaj tsis pub tsawg tshaj 99.0 feem pua ​​thiab tsis ntau tshaj 100.5 feem pua ​​ntawm C15H13FO2, xam nyob rau hauv qhuav.
Ntim thiab khaws cia - Khaws rau hauv cov thawv nruj.
USP Reference cov qauv <11>-
USP Flurbiprofen RS
USP Flurbiprofen Related Compound A RS
2-(4-Biphenylyl) propionic acid.
C15H14O2 226.28
Kev txheeb xyuas-
A: Infrared Absorption <197K>.
B: Ultraviolet Absorption 197U-
Kev daws: 10 µg per mL.
Qhov nruab nrab: 0.1 N sodium hydroxide.
Absorbance siab tshaj plaws ntawm 247 nm yog li 0.8.
Melting ntau <741>: nruab nrab ntawm 114 thiab 117.
Poob ntawm ziab <731>-Sry nws hauv lub tshuab nqus tsev ntawm 60 kom qhov hnyav tas li: nws poob tsis ntau tshaj 0.5% ntawm nws qhov hnyav.
Residue ntawm ignition <281>: tsis ntau tshaj 0.1%.
Cov hlau hnyav, Txoj Kev II <231>: 0.001%.
Related compounds-
Diluent-Npaj sib tov dej thiab acetonitrile (11: 9).
Txawb theem-Npaj lim thiab degassed sib tov dej, acetonitrile, thiab glacial acetic acid (12:7:1).Ua kev hloov kho yog tias tsim nyog (saib System Suitability hauv Chromatography <621>).
Cov txheej txheem kev daws teeb meem- Dissolve ib qho hnyav hnyav ntawm USP Flurbiprofen Related Compound A RS hauv Diluent kom tau txais cov tshuaj uas muaj cov concentration ntawm 50 µg ib mL.
Kev tsim nyog rau kev daws teeb meem-Pipet 2.0 mL ntawm Standard Tshuag tov rau hauv 10-mL ntim ntim, ntxiv txog 20 mg ntawm USP Flurbiprofen RS, dilute nrog Diluent rau ntim, thiab sib tov.
Standard tov-Hloov 2.0 mL ntawm Standard Tshuag tov rau 10.0-mL volumetric hwj, dilute nrog Diluent rau ntim, thiab sib tov.
Test solution-Npaj cov tshuaj Flurbiprofen hauv Diluent uas muaj 2.0 mg ib mL.
Chromatographic system (saib Chromatography <621>)-Cov kua chromatograph yog nruab nrog 254-nm detector thiab 3.9-mm × 15-cm kem uas muaj 4-µm packing L1.Tus nqi ntws yog li 1 mL ib feeb.Chromatograph cov kev daws teeb meem tsim nyog, thiab sau cov lus teb ncov raws li tau qhia rau Cov Txheej Txheem: cov sij hawm tuav cov txheeb ze yog kwv yees li 0.9 rau Flurbiprofen ntsig txog compound A thiab 1.0 rau flurbiprofen;thiab tus txheeb ze tus qauv sib txawv rau kev txhaj tshuaj replicate tsis ntau tshaj 1.0%.
Cov txheej txheem-Kev txhaj tshuaj sib npaug (kwv yees li 20 µL) ntawm cov txheej txheem kev daws teeb meem thiab cov tshuaj ntsuam xyuas rau hauv cov chromatograph, sau cov chromatograms, thiab ntsuas cov cheeb tsam rau cov peaks loj.Xam qhov feem pua ​​​​ntawm flurbiprofen muaj feem xyuam nrog A hauv feem ntawm Flurbiprofen coj los ntawm cov mis:
100 (CS / CU) (rU / rS)
nyob rau hauv uas CS yog qhov concentration, nyob rau hauv µg ib mL, ntawm USP Flurbiprofen Related Compound A RS nyob rau hauv tus txheej txheem tov;CU yog qhov concentration, nyob rau hauv µg ib mL, ntawm Flurbiprofen nyob rau hauv cov tshuaj ntsuam xyuas;thiab rU thiab rS yog cov lus teb siab tshaj plaws rau flurbiprofen ntsig txog cov ntsiab lus A tau los ntawm Kev Ntsuas Tshuaj thiab Cov Txheej Txheem Kev daws teeb meem, raws li: tsis pub ntau tshaj 0.5% ntawm flurbiprofen ntsig txog compound A yog pom.Xam qhov feem pua ​​​​ntawm txhua qhov impurity hauv feem ntawm Flurbiprofen coj los ntawm cov mis:
100 (ri / rs)
nyob rau hauv uas ri yog lub ncov teb rau txhua impurity tau los ntawm Test tov;thiab rs yog tus lej ntawm cov lus teb ntawm tag nrho cov peaks tau txais los ntawm Kev Ntsuas Kev Ntsuas: qhov sib npaug ntawm tag nrho cov impurities tsis ntau tshaj 1.0%.
Assay-Dissolve txog 0.5 g ntawm Flurbiprofen, raug hnyav, hauv 100 mL cawv, yav dhau los neutralized nrog 0.1 N sodium hydroxide VS rau phenolphthalein kawg, ntxiv phenolphthalein TS, thiab titrate nrog 0.1 N sodium hydroxide VS rau thawj qhov tsos. xim liab uas pheej tsis pub tsawg tshaj 30 vib nas this.Txhua mL ntawm 0.1 N sodium hydroxide yog sib npaug rau 24.43 mg ntawm C15H13FO2.