Fmoc-Ile-OH CAS 71989-23-6 Fmoc-L-Isoleucine Purity > 99.0% (HPLC) Hoobkas

Fmoc-L-Isoleucine (Fmoc-Ile-OH) (CAS: 71989-23-6) yog ib qho isoleucine derivative, yog cov amino acid tsis zoo siv rau peptidomimetics.Fmoc-L-isoleucine yog Nα-9-fluorenylmethoxycarbonyl-amino acid.9-fluorenylmethoxycarbonyl yog ib qho tseem ceeb amino tiv thaiv pawg hauv peptide synthesis.Vim tias nws yog pawg tiv thaiv lub hauv paus tseem ceeb thiab ruaj khov rau cov xwm txheej siv los tshem tawm cov pab pawg tiv thaiv, nws muaj lub luag haujlwm tshwj xeeb hauv polypeptide synthesis.Txheem lub tsev thaiv rau niaj hnub khoom theem peptide synthesis tom qab Fmoc-tactics.
Fmoc-amino acids, siv nyob rau hauv peptide synthesis, siv los ua cov organic synthesis intermediate, tshuaj intermediate, biochemical reagent lossis tshuaj reagent.
Kev npaj L-Isoleucine (CAS: 73-32-5) 1.05g (0.008 mol) ntawm cov khoom tau yaj nyob rau hauv 10% sodium carbonate tov, L-isoleucine khoom yog txaus yaj los ntawm stirring.Ntawm 20 ~ 30 ℃, 9-fluorenylmethoxycarbonyl chloride (205g) yaj hauv toluene (2 ~ 2.10) ntxiv dropwise, 0.008 mol) tov, Dropwise ntxiv 30 ~ 60 feeb, qhov kawg ntawm qhov sib ntxiv, ntawm 20 ~ 30 C stirring 1 ~ 8 teev, ntxiv 30 ~ 200 ml ntawm dej dilution, nrog n-butyl acetate (80 ml) tshaj 9-fluorenylmethoxycarbonyl chloride raug tshem tawm los ntawm kev rho tawm, qhov tshwm sim aqueous theem yog acidified nrog concentrated hydrochloric acid rau PH = 0.5 ~ 3.5, ces muab rho tawm nrog n-butyl acetate (80 ml), thiab qhov tshwm sim roj theem tau ntxuav nrog dej kom tshem tawm hydrochloric acid, cov roj theem yog concentrated kom tshem tawm cov n-butyl acetate hnyav, dawb crystals precipitated, lim thiab qhuav kom muab cov khoom. Fmoc-L-Isoleucine 2.48g, tawm los 87.9%, Melting Point: 140.0 ~ 155.0 ℃.